Evaluation of the protective effects of amifostine and melatonin against cisplatin induced testis injury via oxidative stress and apoptosis in rats

Evaluation of protective effects of gallic acid on cisplatin‐induced testicular and epididymal damage

“…They also showed that resveratrol decreased the activity of Caspase‐3 and Bax, but increased the activity of Bcl‐2. In another study, Eren et al., (2020) reported that CP increased the caspase‐3 immunoreactivity in the germinal epithelium and Leydig cells. However, they also revealed that amifostine and melatonin decreased the Caspase‐3 immunoreactivity in the germinal epithelium and Leydig cells.…”

“…Köroğlu et al (2019) found that CP treatment induced a higher levels of 8-OHdG compared to conrtol group in testis of rats. But, they also showed that Apocynin alleviated the DNA damage reducing the levels of 8-OHdG.In another study,Eren et al (2020) reported that the 8-OHdG was increased in testis of CP-received rats in the germinal epithelium and Leydig cells. However, they also revealed that amifostine and melatonin decreasedthe levels of 8-OHdG in the germinal epithelium and Leydig cells.…”

“…However, CP has side effects such as ototoxicity, nephrotoxicity, neurotoxicity, testicular toxicity, as well as signi cant antitumor effects (Elrashidy and Hasan 2020). It has been determined that oxidative stress, in ammation, and ischaemic injury are pathological conditions caused by CP toxicity in non-target tissues (Eren et al 2020).…”

“…However, CP has side effects such as ototoxicity, nephrotoxicity, neurotoxicity and testicular toxicity, as well as significant anti‐tumour effects (Elrashidy & Hasan, 2020). It has been determined that oxidative stress, inflammation and ischaemic injury are pathological conditions caused by CP toxicity in tissues (Eren et al., 2020). The testis has become the target of chemotherapeutic agents due to the spermatogenesis and spermiogenesis in which testicular cell division and morphological changes occur, and these agents can easily damage the testis (Ceylan et al., 2020).…”

“…Thus, infertility occurs in parallel with CP application (Mercantepe et al., 2018). Although the underlying mechanism of CP toxicity on the testis and epididymis is not fully understood, one of its basic mechanisms is estimated to be related to its induction of reactive oxygen species (ROS) production and the decrease in the level of testicular antioxidants (Eren et al., 2020). Thus, the use of natural products that can scavenge ROS with anti‐oxidative capacity is gradually increasing in the treatment of diseases and protection of tissues against intoxication of toxic substances.…”