The existing problems in the field of healthcare and prevention create new challenges and difficulties in various parts of the national public health system. Today, there is an effective set of new sanitary rules and regulations important for competent organization and stable functioning of general medicine wards. In 2023, this set is SanPiN 2.1.3678-20, developed to ensure safe and effective work in medical facilities. There are special bodies tasked with controlling compliance with the standards, including Rospotrebnadzor. The COVID-19 pandemic revealed a number of problems in the organization of work of inpatient departments, which required revision of the ways of rendering medical assistance. This article considers current sanitary and hygienic aspects of organization of operations at a general medicine ward, as well as the approaches to infection prevention in the context of medical care.