Evaluation of the relationship between mitochondrial haplogroup and development of heart failure in Brazilian sample

Fridman, Cíntia; Cardena, M.M.S.G.; Pereira, Alexandre C.

doi:10.1016/j.fsigss.2011.08.038

Cited by 1 publication

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References 13 publications

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“…The possibility that ancestral origin may influence the development of cardiovascular diseases is an interesting notion (Fridman et al, 2011). In this preliminary study, we have established a reliable method for SNP analysis related to SCD, which can be used in a larger number of samples to confirm the association between ancestral origin and disease.…”

Section: Correlation Between Snps Related To Sdc and Y Chromosome Hapmentioning

confidence: 99%

Analysis of SNP (single nucleotide polymorphism) multiplex markers related to sudden cardiac death in Brazilian families

Braganholi

Cicarelli

2015

Genet. Mol. Res.

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ABSTRACT. Sudden cardiac death (SCD) is a major public health concern worldwide, and genetic analysis may be useful in identifying the cause of death as well as in determining the possible genetic risk factors for SCD. This study analyzed eight SNPs (single nucleotide polymorphisms) highly correlated with cardiac sudden death in samples (blood and bone) from six Brazilian families with a history of cardiovascular diseases. Individuals with no family history of cardiovascular diseases were recruited as controls. Y chromosomes and mtDNA haplogroups belonging to these subjects were verified as well. We found that SNP rs16857031 showed significant differences between the group with a family history of cardiovascular diseases and the control group. Furthermore, the data obtained were compatible with known frequencies of SNPs for the haplogroups in which the samples were classified. A possible hereditary factor was identified for SNP rs4725982 in one family. These preliminary results suggest that identification of certain SNPs could be used to assess risk factors for SCD.

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Section: Correlation Between Snps Related To Sdc and Y Chromosome Hapmentioning

confidence: 99%

Analysis of SNP (single nucleotide polymorphism) multiplex markers related to sudden cardiac death in Brazilian families

Braganholi

Cicarelli

2015

Genet. Mol. Res.

View full text Add to dashboard Cite

show abstract

Evaluation of the relationship between mitochondrial haplogroup and development of heart failure in Brazilian sample

Cited by 1 publication

References 13 publications

Analysis of SNP (single nucleotide polymorphism) multiplex markers related to sudden cardiac death in Brazilian families

Analysis of SNP (single nucleotide polymorphism) multiplex markers related to sudden cardiac death in Brazilian families

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