Evaluation of the relationship between the morphometric structure of the pituitary gland and fatigue in patients with multiple sclerosis

Eren, Fettah; Demir, Ayşegül; Yilmaz, Sueda Ecem; Öztürk, Şerefnur

doi:10.1016/j.msard.2022.104470

Cited by 1 publication

(3 citation statements)

References 35 publications

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“…For instance, one study found MS patients with fatigue had significantly higher pituitary heights and widths, along with increased secretion of adrenocorticotropic hormone compared to patients without fatigue. These findings suggest CNS and endocrine systems are involved in the pathogenesis of fatigue through sophisticated regulation of brain structure and function [75].…”

Section: Neuroendocrine Disruption and Hormonal Imbalancementioning

confidence: 96%

“…The qualitative assessment of fatigue is relatively difficult and often subjective, and relies on the use of subjective self-report questionnaires [18,73]. Moreover, experts in different fields may develop professional-specific questionnaires [74,75]. The lack of standardized fatigue measurement across studies, including variations in the specific scales, recall periods, and wording, makes it challenging to compare results and draw definitive conclusions.…”

Section: Subjective and Difficult Measurementmentioning

confidence: 99%

“…In different studies, fatigue can serve as an experimental concept, a symptom, a risk, a cause, and a result [6]. Moreover, the scales for assessing fatigue are varied [74,75] and relatively subjective. There are three models for inducing fatigue, including exhaustive exercise-induced fatigue, and chemotherapy or radiotherapy-induced fatigue [162,163].…”

Section: Current Gaps and Future Perspectivesmentioning

confidence: 99%

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Connecting the dots: the role of fatigue in female infertility

Li,

Huang,

Wei

et al. 2024

Reprod Biol Endocrinol

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Fatigue, an increasingly acknowledged symptom in various chronic diseases, has garnered heightened attention, during the medical era of bio-psycho-social model. Its persistence not only significantly compromises an individual’s quality of life but also correlates with chronic organ damage. Surprisingly, the intricate relationship between fatigue and female reproductive health, specifically infertility, remains largely unexplored. Our exploration into the existing body of evidence establishes a compelling link between fatigue with uterine and ovarian diseases, as well as conditions associated with infertility, such as rheumatism. This observation suggests a potentially pivotal role of fatigue in influencing overall female fertility. Furthermore, we propose a hypothetical mechanism elucidating the impact of fatigue on infertility from multiple perspectives, postulating that neuroendocrine, neurotransmitter, inflammatory immune, and mitochondrial dysfunction resulting from fatigue and its co-factors may further contribute to endocrine disorders, menstrual irregularities, and sexual dysfunction, ultimately leading to infertility. In addition to providing this comprehensive theoretical framework, we summarize anti-fatigue strategies and accentuate current knowledge gaps. By doing so, our aim is to offer novel insights, stimulate further research, and advance our understanding of the crucial interplay between fatigue and female reproductive health.

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Section: Neuroendocrine Disruption and Hormonal Imbalancementioning

confidence: 96%