Evaluation of the Serum Level of Cytokines IL-6, IL-8 Among Patients with Sinusitis in Diyala Governorate, Iraq

Abstract

Sinusitis is inflammatory disorder infecting the mucus epithelial of nasal cavity and paranasal sinuses. This causes the closure of these sinuses and it has negative impact on the patients' life. The present study was conducted in Baqubah Teaching Hospital/ outpatient clinic in Diyala governorate for the period 20 th October, 2022 to 28 th February, 2023. This study involved immune detection about interleukin-eight (IL-8), and interleukin-six (IL-6) by using ELISA. The sample of this study included 88 individuals and it was distributed into 50 patients who suffered from acute and chronic sinusitis. All these were diagnosed by specialized doctors. The males in the sample were 28 (56%), while the females were 22 (44%). The results of the study showed that the infection was higher among males in comparison with females. Also, the current study involved 38 healthy individuals as a control group. It was distributed into 21 males and 17 females. The study showed that the age group 26-35 had the highest infected ratio of sinusitis. In addition, the results showed that there was an increase in the IL-6 in the patients' serum and the ratio was 32.28±13.07 pg/ml in comparison with the control group (9.98±0.70 pg/ml) at the statistic significant level (p<0.001). Another finding of this study was that there was an increase in the level of IL-8 in the patients' serum (214.23±72.58 pg/ml) in comparison with the individuals of the control group (60.09±18.35 pg/ml) at the statistic significant level (p<0.001).