Evaluation of the subtle effects and oxidative stress response of chloramphenicol, thiamphenicol, and florfenicol in <i>Daphnia magna</i>

Zhang, Yuxuan; Wu, Yanmei; Zhang, Xiaoyan; Wang, Meixian; Yang, Simin; Sun, Yongge; Deng, Jun; Su, Haitao

doi:10.1002/etc.4344

Cited by 12 publications

(1 citation statement)

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“…dependent increase in GPx activity and lipid peroxidation levels should be viewed through redox balance, which tipped toward oxidation at higher Flx and NorFlx concentrations. Similar concentration-dependent changes in D. magna was reported with organochlorine insecticide endosulfan (51) and antibiotic chloramphenicol (52).…”

Section: 0±489 CDsupporting

confidence: 81%

Oxidative and apoptotic effects of fluoxetine and its metabolite norfluoxetine in Daphnia magna

Över

Güven

Taşkın

et al. 2020

Archives of Industrial Hygiene and Toxicology

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The aim of this study was to investigate the oxidative and apoptotic potential of fluoxetine, a widely used antidepressant in Turkey and the world, and of its metabolite norfluoxetine on a model non-target organism, Daphnia magna to see how exposure to this group of antidepressants (specific serotonin reuptake inhibitors) could affect the aquatic environment in which they end up. Juvenile D. magna specimens were chronically exposed to fluoxetine and norfluoxetine alone and in combination at concentrations found in the aquatic environment (0.091 and 0.011 μg/L, respectively) and to their 10-fold environmental concentrations for 21 days. Another group of 17-day-old animals were subacutely exposed to 100-fold environmental concentrations for four days. After exposure, we measured their glutathione peroxidase (GPx) and cholinesterase (ChE) activities, thiobarbituric acid-reactive substances (TBARS), and total protein content spectrophotometrically, while mitochondrial membrane potential (MMP) was analysed by fluorescence staining, and cytochrome c and ERK1/2 protein content by Western blotting. This is the first-time cytochrome c and ERK1/2 were determined at the protein level in D. magna. We also measured their carapace length, width, and caudal spine length microscopically. At environmental concentrations fluoxetine and norfluoxetine caused an increase in ChE activity and brood production. They also caused a decrease in juvenile carapace length, width, and caudal spine length and depolarised the mitochondrial membrane. At 10-fold environmental concentrations, GPx activity, lipid peroxidation levels, cytochrome c, and ERK1/2 protein levels rose. The most pronounced effect was observed in D. magna exposed to norfluoxetine. Norfluoxetine also decreased brood production. Similar effects were observed with subacute exposure to 100-fold environmental concentrations. However, total protein content decreased. All this confirms that fluoxetine and norfluoxetine have oxidative and apoptotic potential in D. magna. Daphnia spp. have a great potential to give us precious insight into the mechanisms of environmental toxicants, but there is still a long way to go before they are clarified in these organisms.

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Section: 0±489 CDsupporting

confidence: 81%

Oxidative and apoptotic effects of fluoxetine and its metabolite norfluoxetine in Daphnia magna

Över

Güven

Taşkın

et al. 2020

Archives of Industrial Hygiene and Toxicology

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Evaluation of the Acute Effects and Oxidative Stress Responses of Phenicol Antibiotics and Suspended Particles in Daphnia magna

Zhang

Wang

et al. 2021

Enviro Toxic and Chemistry

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Suspended particles (SP) exist widely in various water systems and are able to adsorb other pollutants in water, producing ecotoxic effects on aquatic nontarget species. Until now, however, few studies have focused on the effects of SP on antibiotics. Therefore, the present study investigated the effects of the mixtures of SP and phenicol antibiotics (chloramphenicol [CAP], thiamphenicol [TAP]) on acute toxicity and oxidative stress responses in Daphnia magna. The results indicated that the acute toxicity of phenicol antibiotics in D. magna was increased when combined with SP. Besides, the immobilization of daphnids caused by phenicol drugs in the presence of 10 mg/L of SP was more intense than that with 200 mg/L of SP. Furthermore, the impact of SP with diverse concentrations on the activity of catalase and the level of reduced glutathione in D. magna was different. Notably, almost all CAP + TAP + SP treatments markedly increased malondialdehyde content in D. magna, causing potential cellular oxidative damage in D. magna. In summary, the present study provides insights into the toxic effects of phenicol antibiotic and SP mixtures on aquatic organisms. Environ Toxicol Chem 2021;40:2463–2473. © 2021 SETAC

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Aptasensors in environmental forensics: Tracking the silent killers

Dube

Satish

Rawtani

2023

WIREs Forensic Science

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Since its inception, environmental forensics has observed expansion of its horizons across several threats to life forms, be it pertaining to wildlife trafficking or tracking the release of effluents containing pharmaceutical drugs, toxins, pesticides, heavy metals, pathogenic microbes, and microplastics. With the substantial growth of pharmaceutical industry over the past few decades, especially with respect to therapeutic personal care products and over the counter drugs, a new threat to environment has emerged from pharmaceutical toxicity.Due to the recalcitrant nature and poor wastewater treatment practices related to these pollutants, they leach into different strata of ecosystem like aquatic, terrestrial, and atmospheric systems. These drugs pose a threat to several life forms even at trace concentrations. This article aims at providing a profound perspective by exhaustively reviewing several classes of pharmaceutical drugs that are silently threatening the wildlife and environment. The sensitive, specific, and rapid detection of such drugs menacing the environment and wildlife is pertinent and can be achieved through aptamer-based biosensors known as aptasensors. These are a rising class of biosensors with vast application potential in numerous fields including environmental and wildlife forensics. This article also highlights the gap in research in the availability of rapid sensors for trace detection of drugs in environment hence encouraging researchers to explore the under-explored potential of aptasensors in environmental forensics. Highly sensitive and selective detection of such drugs is crucial in narrowing down the origin of such pollutants so as to aid the regulatory authorities in enforcing control over their release into environment.

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Evaluation of the subtle effects and oxidative stress response of chloramphenicol, thiamphenicol, and florfenicol in Daphnia magna

Cited by 12 publications

References 50 publications

Oxidative and apoptotic effects of fluoxetine and its metabolite norfluoxetine in Daphnia magna

Oxidative and apoptotic effects of fluoxetine and its metabolite norfluoxetine in Daphnia magna

Evaluation of the Acute Effects and Oxidative Stress Responses of Phenicol Antibiotics and Suspended Particles in Daphnia magna

Aptasensors in environmental forensics: Tracking the silent killers

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