Evaluation of the subunit α7 expression of nicotinic acetylcholine receptor and activation of proteins (JAK2/STAT3 and CREB) of cholinergic anti-inflammatory pathway in the offspring mice spleen with obesity induced by maternal high fat consumption

Abstract

Gestational obesity is one of the most common obstetric risks and its prevalence has been increasing substantially. It is known that in obesity there is a loss of the cholinergic signalling responsible for the anti-inflammatory reflex which leads to an immune system imbalance. We hypothesize that the offspring (28 days old) of the maternal high fat diet consumption during the gestational and the lactation periods shows an impared cholinergic anti-inflammatory reflex. From this point on, an increase of inflammatory cytokines in the HFD-O spleen, such as TNF and IL1β, was observed, and this increase seems to be responsive to the smallest phosphorylation of STAT3 and the increase of the expression of NFkB.