Evaluation of the volatile composition and fatty acid profile of seven Antarctic macroalgae

Berneira, Lucas M.; Silva, Caroline da; Poletti, Tais; Ritter, Marina; Santos, Marco dos; Colepicolo, Pio; Pereira, Cláudio M. P.

doi:10.1007/s10811-020-02170-9

Cited by 16 publications

(13 citation statements)

References 45 publications

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“…This correlation can be observed by the clustering of these parameters mostly in the positive axis of PC1. These conclusions agree with previous studies, which indicated that the chemical composition of macroalgae can be directly linked to the organism (Berneira et al 2020;Kumari et al 2009).…”

Section: Discussionsupporting

confidence: 93%

“…Santos et al (2017b) and Cortés et al (2014) analyzed dichloromethane extracts from Bifurcaria bifurcata R.Ross and Ceramium rubrum C. Agardh, respectively, and detected similar compounds (Cortés et al 2014;Santos et al 2017b). It is worth noting that, to the best of our knowledge, this was the first time that lipophilic extracts from M. laminarioides at distinct phases The presence and concentration of secondary metabolites in macroalgae are controlled by several environmental conditions that include, for instance, temperature, seasonality, pH, salinity and development phase (Santos et al 2017a;Berneira et al 2020). In this sense, evaluation of the life stages of M. laminarioides revealed significant differences (P < 0.05) in the chemical classes as the cystocarpic phase had higher concentrations of hydrocarbons and fatty acids than other development phases.…”

Section: Discussionmentioning

confidence: 79%

“…Previous studies have indicated that macroalgae components from Antarctic or sub-Antarctic could be a prominent source of pharmacological constituents mainly as antibacterial, antifungal and anticancer agents due to the presence of unique secondary metabolites found in these organisms (Martins et al 2018;Pacheco et al 2018;Berneira et al 2020). Among these secondary metabolites, polyunsaturated fatty acids and volatile organic compounds, for instance, could be associated with the bioactivities of macroalgae extracts (Santos et al 2017a;Pacheco et al 2018.…”

Section: Discussionmentioning

confidence: 99%

“…Previous research works showed that macroalgae can be sources of terpenes, phenols (Fernandes et al 2017), sterols, proteins (Pereira et al 2017), carbohydrates and lipids that are produced as secondary metabolites (Boulom et al 2014;Berneira et al 2020). The vast number of synthesized compounds can be associated with several biological activities reported in the literature including anti-inflammatory (Tenorio-Rodriguez et al 2017), antimutagenic (Osuna-Ruiz et al 2016), antiviral, antimicrobial (Martins et al 2018) and antioxidant actions (Alves et al 2016).…”

Section: Introductionmentioning

confidence: 99%

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Bioactivity evaluation and composition of extracts from sub-Antarctic macroalgae Mazzaella laminarioides at distinct development phases

et al. 2020

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Sub-Antarctic macroalgae can be a feasible source of innumerous bioactive compounds that can display important biological activities. In this sense, the aims of this work were to evaluate the chemical composition, antimicrobial activity and cytotoxic potential of n-hexane extracts from sub-Antarctic seaweed Mazzaella laminarioides (Bory) Fredericq at distinct development phases. Results showed that extracts were constituted of as much as 65 distinct compounds that could be distributed mainly among hydrocarbons, fatty acids, sterols and fatty alcohols. Generally, there were significant differences (P < 0.05) in the concentrations of compounds comparing distinct development phases. Antimicrobial evaluation indicated that n-hexane extracts of cystocarpic and tetrasporophytic phase of M. laminarioides inhibited the growth of most organisms tested, reaching minimum inhibitory concentrations of 0.0312 mg mL −1 against Enterococcus faecalis (Andrewes and Horder) and 0.25 mg mL −1 against Acinetobacter baumannii (Bouvet and Grimont). Cytotoxic evaluation of extracts showed no toxicity to normal cells at concentrations below 1 mg mL −1. Therefore, M. laminarioides from the sub-Antarctic region had antimicrobial potential that could be explored on further commercial applications.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Bioactivity evaluation and composition of extracts from sub-Antarctic macroalgae Mazzaella laminarioides at distinct development phases

et al. 2020

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“…Aldehydes are volatile biochemicals which are produced by seaweeds, have low molecular weights, are mostly lipophilic, and are considered the most important parameters of food flavor and quality [20,21]. Aromatic aldehydes have also been reported to possess a wide range of potential bioactive properties including anti-cancer, antibacterial, antioxidant, anti-inflammation, and immunomodulatory effects [22][23][24][25][26][27].…”

Section: Introductionmentioning

confidence: 99%

In Silico Virtual Screening of Marine Aldehyde Derivatives from Seaweeds against SARS-CoV-2

et al. 2022

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Coronavirus disease 2019, caused by the outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is an ongoing global pandemic that poses an unprecedented threat to the global economy and human health. Several potent inhibitors targeting SARS-CoV-2 have been published; however, most of them have failed in clinical trials. This study aimed to assess the therapeutic compounds among aldehyde derivatives from seaweeds as potential SARS-CoV-2 inhibitors using a computer simulation protocol. The absorption, distribution, metabolism, excretion, and toxicity (ADME/Tox) properties of the compounds were analyzed using a machine learning algorithm, and the docking simulation of these compounds to the 3C-like protease (Protein Data Bank (PDB) ID: 6LU7) was analyzed using a molecular docking protocol based on the CHARMm algorithm. These compounds exhibited good drug-like properties following the Lipinski and Veber rules. Among the marine aldehyde derivatives, 4-hydroxybenzaldehyde, 3-hydroxybenzaldehyde, 3,4-dihydroxybenzaldehyde, and 5-bromoprotocatechualdehyde were predicted to have good absorption and solubility levels and non-hepatotoxicity in the ADME/Tox prediction. 3-hydroxybenzaldehyde and 3,4-dihydroxybenzaldehyde were predicted to be non-toxic in TOPKAT prediction. In addition, 3,4-dihydroxybenzaldehyde was predicted to exhibit interactions with the 3C-like protease, with binding energies of −71.9725 kcal/mol. The computational analyses indicated that 3,4-dihydroxybenzaldehyde could be regarded as potential a SARS-CoV-2 inhibitor.

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Fatty acid profiles and stable isotope composition of Antarctic macroalgae: a baseline for a combined biomarker approach in food web studies

Whippo,

Iken,

Amsler

et al. 2024

Polar Biol

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The Western Antarctic Peninsula supports a diverse assemblage of > 100 described macroalgal species that contribute to the base of coastal food webs, but their contribution to local nearshore food webs is still uncertain across larger spatial scales. The analysis of biomarkers, specifically fatty acids and stable isotopes, offers a tool to clarify the trophic role of Antarctic macroalgae. The aim of this study was to describe the fatty acid profiles and stable isotope values of 31 algal species from three divisions (Chlorophyta—1, Ochrophyta—8, Rhodophyta—22) collected at the same sites for both biomarkers. Of these, 13 species had no previously published fatty acid profiles. Most species were rich in polyunsaturated fatty acids (PUFAs), suggesting they are highly nutritious and could be a resource of essential fatty acids for consumers. This was specifically noticeable in the overall low PUFA ratio (∑ω6/∑ω3 ratio), with low ratios being an indicator of high nutritional quality for consumers. Fatty acid profiles of macroalgae grouped strongly by phylogeny (at the levels of division, order, and family), while stable isotope groupings were more driven by the physiological properties of the species. Specifically, some closely related red algal species exhibited very different stable isotope values based on their carbon concentrating mechanisms, with highly 13C-depleted values in several Rhodophyta species. The fact that the two biomarker approaches created different groupings of Antarctic macroalgae collected at the same locations emphasizes that their combined application can be a powerful tool in Antarctic coastal food web studies.

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Evaluation of the volatile composition and fatty acid profile of seven Antarctic macroalgae

Cited by 16 publications

References 45 publications

Bioactivity evaluation and composition of extracts from sub-Antarctic macroalgae Mazzaella laminarioides at distinct development phases

Bioactivity evaluation and composition of extracts from sub-Antarctic macroalgae Mazzaella laminarioides at distinct development phases

In Silico Virtual Screening of Marine Aldehyde Derivatives from Seaweeds against SARS-CoV-2

Fatty acid profiles and stable isotope composition of Antarctic macroalgae: a baseline for a combined biomarker approach in food web studies

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