Evaluation of Thyroid Hormone Abnormalities and Thyroid Autoantibodies in Chronic Idiopathic Urticaria and Alopecia Areata Egyptian Patients

Patients with chronic spontaneous urticaria (CSU) are widely held to often have other autoimmune disorders, including autoimmune thyroid disease. Here, we systematically evaluated the literature on the prevalence of thyroid autoimmunity in CSU and vice versa. There is a strong link between CSU and elevated levels of IgG antithyroid autoantibodies (AAbs), with most of a large number of studies reporting rates of ≥10%. Levels of IgG against thyroid peroxidase (TPO) are more often elevated in CSU than those of other IgG antithyroid AAbs (strong evidence). Levels of IgG antithyroid AAbs are more often elevated in adult patients with CSU than in children (strong evidence). Patients with CSU exhibit significantly higher levels of IgG antithyroid AAbs (strong evidence) and IgE-anti-TPO (weak evidence) than controls. Elevated IgG antithyroid AAbs in CSU are linked to the use of glucocorticoids (weak evidence) but not to disease duration or severity/activity, gender, age, or ASST response (inconsistent evidence). Thyroid dysfunction rates are increased in patients with CSU (strong evidence). Hypothyroidism and Hashimoto's thyroiditis are more common than hyperthyroidism and Graves' disease (strong evidence). Thyroid dysfunction is more common in adult patients with CSU than in children (strong evidence) and in female than in male patients with CSU (weak evidence). Urticaria including CSU is more prevalent in patients with thyroid autoimmunity than in controls (weak evidence). CSU can improve in response to treatment with levothyroxine or other thyroid drugs (strong evidence). Pathogenic mechanisms in CSU patients with thyroid autoimmunity may include IgE against autoantigens, immune complexes, and complement.

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“…In two studies, but not all studies, patients with CSU had significantly higher rates of thyroid dysfunction compared to HCs.…”

Section: Resultsmentioning

confidence: 81%

Comorbidity of chronic spontaneous urticaria and autoimmune thyroid diseases: A systematic review

Kolkhir

Metz

Altrichter

et al. 2017

Allergy

149

118

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“…Dermatitis herpetiformis is associated with other disorders and complications that likely reflect the spectrum of CD. Some diseases occur more frequently in CD patients, for example, autoimmune thyroid diseases occur in 20-30% of the CD cases [8] and Insulin-dependent diabetes and lymphoma occur in less than 5 % of CD cases, while other autoimmune diseases such as alopecia areata, Addison's disease, vitiligo, and psoriasis occur infrequently [8], [9]. Results of this study indicate an association between AA and CD tests, and these studies are similar to several studies which state a relationship between AA and CD.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of anti-tissue Transglutaminase antibodies among patients with alopecia areata in Nassiriah city.

Rhadi¹,

Naif

Hassan³

2019

University of Thi-Qar Journal

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Background: alopecia areata is an autoimmune disease in which hair is lost from some or all areas of the body, usually from the scalp due to the body's failure to recognize its own body cells and subsequent destruction of its own tissue as if it were an aggressor. The Anti-tissue transglutaminase antibodies, antibodies against the enzyme tissue transglutaminase (tTG), are found in the blood of some patients with alopecia areata. Serological blood tests such as anti-tissue transglutaminase antibodies are the first-line non-invasive investigation required to make a diagnosis of celiac disease.Aims: the aim of the study is to establish the prevalence of Anti-tissue transglutaminase antibodies in patients with alopecia areata.Methods: we evaluated 96 serum samples. The samples were collected from two groups; group I of sixty five patients with alopecia areata and group II of thirty one control patients who were referred to dermatology department in al-hussaien teaching hospital for different dermatological diseases other than alopecia areata. All participants were evaluated for anti-tissue transglutaminase IgA and anti-tissue transglutaminase IgG antibodies.Results: out of the 65 patients with alopecia areata included in the study, tTGA was positive in 13 patients (20%) and tTGG was positive in 8 patient (12.4%). The prevalence of positivity in patients with alopecia areata was

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“…anti-Tg, anti-tiroglobulina anti-TPO, anticuerpo antiperoxidasa TSH, thyroid stimulating hormone UC, urticaria crónica UCE, urticaria crónica espontánea dismo (TSH < 0.39 µU/L para el tipo subclínico y < 0.1 µU/L para el clínico). 11,12,13,14 En urticaria crónica se ha propuesto que la generación de citocinas tiene un efecto directo sobre el hipotálamo y la producción de TSH; el propio aumento de la TSH deriva en mayor expresión de receptores para interleucina (IL) 1, IL-2, IL-6, factor de necrosis tumoral-α, interferón-γ, leucotrienos y prostaglandinas, perpetuando el círculo vicioso. En pacientes con anticuerpos antitiroideos positivos, ya sea anti-TPO o anti-tiroglobulina (anti-Tg), estos tienen la propiedad de degranular células cebadas por sí mismos.…”

Section: Abreviaturas Y Siglasunclassified

Alteraciones tiroideas en urticaria crónica espontánea

O’Farrill-Romanillos

Álvarez-Chávez

Xochihua-García

2019

RAM

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Artículo original 403 http://www.revistaalergia.mx Rev Alerg Mex. 2019;66(4):403-408 403 Thyroid disorders in spontaneous chronic urticaria Alteraciones tiroideas en urticaria crónica espontánea Este artículo debe citarse como: O'Farrill-Romanillos PM, Álvarez-Chávez FE, Xochihua-García JJ. Alteraciones tiroideas en urticaria crónica espontánea. Rev Alerg Mex. 2019;66(4):403-408 AbstractBackground: Chronic spontaneous urticaria (CSU) is linked to thyroid disease in up to 54%, with predominance of hypothyroidism. Objective: To describe the impairments of the thyroid function in patients with CSU in a third level of care. Methods: A cross-sectional, observational, and descriptive study in which we have included men and women over 18-year-old with CSU; in which TSH and free T4 were quantified. According to the results, they were classified as euthyroid, hyperthyroid, and hypothyroid; in the latter ones, the presence of antithyroid antibodies was intentionally sought. The demographic and biochemical characteristics of the results were assessed. Results: The clinical characteristics of 127 patients with CSU were analyzed. Women accounted for 78%. The average age was 44.5 ± 15.1 years. Impairments of the thyroid function were identified in 50 patients (39%), and subclinical hypothyroidism (SH) occurred in 41 (82%) of them; patients with hyperthyroidism were not found. Of the patients with hypothyroidism, 14 (28%) presented positive antibodies; all of them were women. Conclusions: More than a third of the analyzed patients with CSU presented impairments of the thyroid function; subclinical hypothyroidism (SH) was more common. The importance of identifying this entity lies in the possibility of a multidisciplinary treatment with endocrinology. Subsequent studies may establish whether the presence of hypothyroidism influences the activity of CSU.

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Evaluation of Thyroid Hormone Abnormalities and Thyroid Autoantibodies in Chronic Idiopathic Urticaria and Alopecia Areata Egyptian Patients

Cited by 6 publications

References 7 publications

Comorbidity of chronic spontaneous urticaria and autoimmune thyroid diseases: A systematic review

Comorbidity of chronic spontaneous urticaria and autoimmune thyroid diseases: A systematic review

Prevalence of anti-tissue Transglutaminase antibodies among patients with alopecia areata in Nassiriah city.

Alteraciones tiroideas en urticaria crónica espontánea

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