Evaluation of toxicological, diuretic, and laxative properties of ethanol extract from Macrothelypteris Torresiana (Gaudich) aerial parts with In silico docking studies of polyphenolic compounds on carbonic anhydrase II: An enzyme target for diuretic activity

Mondal, Sambhu Charan; Panigrahi, Naresh; Sancheti, Purab; Tirkey, Ruchi; Mondal, Prasenjit; Almas, Sara; Kola, Venu

doi:10.4103/pr.pr_16_18

Cited by 5 publications

(7 citation statements)

References 3 publications

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“…No toxicity (genotoxicity, mutagenicity, oral toxicity) was observed in this case [ 50 , 51 ]. In the case of Macrothelypteris torresiana , no acute toxicity was observed at 2000 mg·kg −1 , along with no changes in hematological and biochemical parameters [ 52 ]. The acute and sub-chronic toxicity of Dryopteris filix-mas ethanol leaf extract was evaluated [ 53 ].…”

Section: Resultsmentioning

confidence: 99%

Nutritional and Antioxidant Potential of Fiddleheads from European Ferns

Dvořáková

Pumprova

Antonínová

et al. 2021

Foods

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Ferns are part of the diet and traditional medicine in East Asia, North America, and Oceania, however, their importance has been forgotten in Europe. Here, the nutritional and antioxidant potential of young fern fronds (fiddleheads) of eight families were studied. Most of the tested fern species excelled in high antioxidant capacity when compared to the reference leafy vegetables spinach and rocket. On average, the total phenol content reached 220 mg·g−1 of extract dry weight for all fiddleheads, and 15 out of 24 tested species exceeded 1 g Trolox equivalent per gram of extract dry weight in Oxygen Radical Absorbance Capacity (ORAC) assay. On the other hand, fiddleheads contained a comparable amount of carotenoids and ascorbic acid with the reference vegetables. In the case of fatty acid composition, fiddleheads contained especially high amounts of essential omega-3 (n3) and omega-6 (n6) polyunsaturated fatty acids with a beneficial n6/n3 ratio. The n6/n3 ratio in all tested species was between 2 and 6.4, whereas the ratio in the reference vegetables was below 0.4. All in all, fiddleheads from European ferns are a rich source of valuable antioxidants and essential fatty acids with a desirable n-6/n-3 ratio and may thus form an alternative source of these compounds, especially for those people not consuming fish and fish products.

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Section: Resultsmentioning

confidence: 99%

Nutritional and Antioxidant Potential of Fiddleheads from European Ferns

Dvořáková

Pumprova

Antonínová

et al. 2021

Foods

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“…RKCP/COI/RA/21/107. The diuretic activity was evaluated as per Mondal et al 18 Wistar rats of either sex, weighing 200/220g, were divided into six groups of six animals each. Before experimentation, the animals were assessed for any disease indication, and only the healthy animals were chosen for the study.…”

Section: Diuretic Activitymentioning

confidence: 99%

“…The plant's laxative potential was measured using Mondal et al 18 The same animals used in diuretic activity were used for laxative activity after a washing period of 3 weeks as the sacrifice of animals is not required to evaluate diuretic activity. Rats of either sex fasted for 12 hr before the experiment but with water provided ad libitum.…”

Section: Laxative Activitymentioning

confidence: 99%

Evaluation of Diuretic and Laxative Potential of Onosma bracteata Wall.: A Species of the Controversial Drug ‘Gojihva’

Vegad

Pandya

2022

IJPI

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Background: Gojihva or Gaozaban, an Ayurvedic cum Unani Medicinal plant described with various properties, including diuretic activity. Onosma bracteata Wall. is considered the official species of Gojihva in Ayurveda and is one of the species considered Unani Gaozaban. Materials and Methods: The plant was subjected to physicochemical evaluation, sequential extraction, HPTLC profiling, and phytochemical screening. The diuretic and laxative activity of sequential methanol and water extracts of O. bracteata Wall. at a dose of 100 mg/kg and 200 mg/kg of body weight per oral was measured in Wistar rats in two separate experiments. Results: Preliminary phytochemical investigation and TLC profiling revealed the presence of flavonoids/hydroquinone/phenolics in methanol extract. Additionally, elemental analysis of plant material detected Potassium (K) at a level of 672.12 ppm. The methanol extract at doses 100 mg/kg (1.65 mL ± 0.19) and 200 mg/kg (2.00 mL ± 0.28) and aqueous extract at dose 200 mg/kg (1.63 ± 0.12) showed highly significant diuretic activity (p<0.0001) at 6 h compared to standard (0.67 mL ± 0.21). Whereas the aqueous extract of the plant showed mild constipation action. Conclusion: The literature search revealed that the diuretic potential of the methanolic extract could be attributed majorly to carbonic anhydrase inhibitory activity of constituent compounds like caffeic acid, rosmarinic acid, p-hydroxybenzoic acid, artitrichin, salvianolic acid, and coumarins, in addition to natriuretic, Ca 2+ sparing activity, and increased renal excretory function. The milder diuretic action of the aqueous extract can be due to the presence of potassium salts in aqueous extracts. Thus, the traditional use of Gojihva as a diuretic is established on a phytochemical basis. Further pharmacological and phytochemical investigations of Methanol extract may reveal novel compounds with diuretic potential.

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“…After the fasting period, all animals were weighed, and their dosages were calculated based on their body weight. The extract was dissolved in distilled water, and the test was carried out according to methods of Sumanta Mondal et al 11 and Shivhare et al 12 Aqueous extract of Dhatupaushtik churna (AEDC) was administered orally at 1000 mg/kg and 2000 mg/kg, respectively for groups II and III as per body weight of mice. Group I was used as control group that received only distilled water (3 mL/kg, p.o.).…”

Section: Acute Toxicity Studymentioning

confidence: 99%

“…The subacute toxicity of Dhatupaushtik churna aqueous extract was performed following the method of Halim et al 14 and Mondal et al 11 Healthy adult male Wistar rats were randomly assigned into three groups each containing six male rats. Group I received only distilled water (3 mL/kg, p.o.)…”

Section: Subacute Toxicity Studymentioning

confidence: 99%

Acute and Sub-Acute Toxicity Studies of Dhatupaushtik Churna

2021

TJNPR

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Evaluation of toxicological, diuretic, and laxative properties of ethanol extract from Macrothelypteris Torresiana (Gaudich) aerial parts with In silico docking studies of polyphenolic compounds on carbonic anhydrase II: An enzyme target for diuretic activity

Cited by 5 publications

References 3 publications

Nutritional and Antioxidant Potential of Fiddleheads from European Ferns

Nutritional and Antioxidant Potential of Fiddleheads from European Ferns

Evaluation of Diuretic and Laxative Potential of Onosma bracteata Wall.: A Species of the Controversial Drug ‘Gojihva’

Acute and Sub-Acute Toxicity Studies of Dhatupaushtik Churna

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