Evaluation of Tp-e interval, Tp-e/QT ratio and Tp-e/QTc ratio in patients with acute myocarditis

Uçar, Fatih Mehmet; Öztürk, Cihan; Yılmaztepe, Mustafa Adem

doi:10.1186/s12872-019-1207-z

Cited by 31 publications

(22 citation statements)

References 19 publications

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“…Regarding ECG markers of repolarization disturbances, QTc, Tp‐e interval, and TDR have a prognostic significance in the prediction of increased risk of malignant arrhythmia and morality in patients with certain cardiovascular diseases, such as coronary artery disease and myocarditis 22 . ECG changes, such as QTc prolongation, conduction and repolarization abnormalities, and ventricular arrhythmias, may reflect myocardial injury directly or indirectly associated with COVID‐19 pneumonia 23 .…”

Section: Discussionmentioning

confidence: 99%

ECG markers of malignant arrhythmias and in‐hospital outcome of COVID‐19 pneumonia

Shaghee¹,

Nafakhi

Alareedh

et al. 2021

Journal of Arrhythmia

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Background ECG abnormalities associated with COVID‐19 pneumonia and adverse outcome are undefined and poorly described in prior studies. Objectives To assess the predictive role of baseline ECG markers of increased risk of malignant arrhythmias and cardiac death for adverse in‐hospital outcomes. Patients and methods A retrospective study included 93 patients of newly diagnosed COVID‐19 with features consistent with pneumonia who were admitted to the hospital from August 20 to September 20, 2020. The main outcomes were defined as receiving mechanical ventilation, in‐hospital cardiac arrest, length of ICU stay, and degree of lung damage according to computed tomography (CT) score. Results Increased QTc (QT corrected) interval, Tp‐e (T from peak to end) interval, and transmural dispersion of repolarization (TDR) were independent predictors of prolonged ICU stay ( P < .0001) after adjustment for baseline clinical characteristics. Increasing age ( P < .0001) followed by increased QTc interval ( P = .02) and history of chronic lung disease ( P = .04) were independent predictors of extensive lung damage. The independent predictors for in‐hospital cardiac arrest were increased QTc ( P = .02) followed by increasing age ( P = .04) and increased Tp‐e interval ( P = .04). Conclusion Repolarization abnormalities on baseline ECG may be useful prognostic markers in patients with COVID‐19 pneumonia.

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Section: Discussionmentioning

confidence: 99%

ECG markers of malignant arrhythmias and in‐hospital outcome of COVID‐19 pneumonia

Shaghee¹,

Nafakhi

Alareedh

et al. 2021

Journal of Arrhythmia

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“…Epicardial action potential is represented with the peak of T-wave in ECG and the end of myocardial action potential is represented with the end of the T wave. Therefore, Tp-e interval is an indicator of transmural depolarization 20 , 21 . The prolongation of TP-e interval has been previously demonstrated in Brugada syndrome, long QT syndrome, hypertrophic cardiomyopathy, in conventional smokers, patients with obstructive sleep apnea and Behcet's disease 11 , 15 , 21 – 23 .…”

Section: Discussionmentioning

confidence: 99%

Acute effects of electronic cigarette smoking on ventricular repolarization in adults

et al. 2020

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Background: Electronic cigarette (e-cigarette) use is constantly increasing. However, the association between e-cigarette use and ventricular arrhythmia is unknown. Thus, in this study, we aimed to evaluate the markers of ventricular repolarization such as QT interval, corrected QT (QTc), QT dispersion (QTd), peak-to-end interval of the T wave (Tp-e), corrected Tp-e and Tp-e/QT ratios in e-cigarette users. Methods: The study population consisted 36 e-cigarette users and 40 healthy subjects. Ventricular repolarization parameters were obtained from 12-lead resting electrocardiogram. Ventricular repolarization parameters of the groups were compared. Results: Basal demographic and laboratory data were similar in both groups. According to the electrocardiographic parameters, the Tp-e interval, corrected Tp-e, and Tp-e/QT ratio were significantly higher in individuals using e-ciga- rettes than in control subjects [74.9±6.4 milliseconds (ms) vs. 80.1±4.1ms, <0.001; 82.9±7.5 ms vs. 87.8±6.3 ms, p=0.003; 0.20±0.01 vs. 0.21±0.01, p=0.002; respectively]. Conclusion: This is the first study to show the disruption of ventricular repolarization properties in e-cigarette users. E-cig- arette use in terms of public health leads to augmentation of transmural dispersion of repolarization, which may be potential indicator of ventricular arrhythmogenesis. Keywords: Electronic cigarette; ventricular repolarization; Tp-e interval; Tp-e/QT ratio.

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“…In a cohort of 186 subjects with acute myocarditis the presence of at least one ectopic ventricular beat on the admission ECG, wide QRS complex and long QT segment were associated to cardiac death independently of LVEF at a median follow-up of 55 months [ 67 ]. The relevance of QT interval in identifying subjects at increased risk for ventricular arrhythmias has been recently confirmed in a small report on 56 subjects with acute myocarditis and preserved LVEF [ 68 ]. The investigators also reported an increased T wave peak-to-end interval in subjects with sustained ventricular arrhythmias at follow-up.…”

Section: Risk Stratification Of Scd In Patients With Acute Myocarditismentioning

confidence: 99%

Sudden Cardiac Death in Patients with Heart Disease and Preserved Systolic Function: Current Options for Risk Stratification

Pannone

Falasconi

Cianfanelli

et al. 2021

JCM

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Sudden cardiac death (SCD) is the leading cause of cardiovascular mortality in patients with coronary artery disease without severe systolic dysfunction and in heart failure with preserved ejection fraction. From a global health perspective, while risk may be lower, the absolute number of SCDs in patients with left ventricle ejection fraction >35% is higher than in those with severely reduced left ventricle ejection fraction (defined as ≤35%). Despite these observations and the high amount of available data, to date there are no clear recommendations to reduce the sudden cardiac death burden in the population with mid-range or preserved left ventricle ejection fraction. Ongoing improvements in risk stratification based on electrophysiological and imaging techniques point towards a more precise identification of patients who would benefit from ICD implantation, which is still an unmet need in this subset of patients. The aim of this review is to provide a state-of-the-art approach in sudden cardiac death risk stratification of patients with mid-range and preserved left ventricular ejection fraction and one of the following etiologies: ischemic cardiomyopathy, heart failure, atrial fibrillation or myocarditis.

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Evaluation of Tp-e interval, Tp-e/QT ratio and Tp-e/QTc ratio in patients with acute myocarditis

Cited by 31 publications

References 19 publications

ECG markers of malignant arrhythmias and in‐hospital outcome of COVID‐19 pneumonia

ECG markers of malignant arrhythmias and in‐hospital outcome of COVID‐19 pneumonia

Acute effects of electronic cigarette smoking on ventricular repolarization in adults

Sudden Cardiac Death in Patients with Heart Disease and Preserved Systolic Function: Current Options for Risk Stratification

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