Evaluation of trabecular bone score in men with type 1 diabetes

Karytska, Nadzeya; Dydyshka, Yuliya; Shepelkevich, Alla; Vasilyeva, Natallia; Vadzianava, Volha; Zhukouskaya, Volha V.

doi:10.1530/endoabs.63.p100

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“…We observed a significantly lower TBS among men with T1D compared to healthy controls. This is in accordance with Karytska et al, who described lower TBS in men with T1D compared to healthy controls 24 , and with Shah et al, who reported that adults of both genders with T1D displayed lower TBS than controls 25 . On the other hand, Neumann et al observed reduced TBS only among T1D subjects with prevalent fractures 15 .…”

Section: Discussionsupporting

confidence: 92%

Evidence of impaired bone quality in men with type 1 diabetes: a cross-sectional study

Syversen

Mosti

Mynarek

et al. 2021

Endocrine Connections

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Objective: Type 1 diabetes (T1D) is associated with a substantial fracture risk. Bone mineral density (BMD) is, however, only modestly reduced, suggesting impaired bone microarchitecture and/or bone material properties. Yet, the skeletal abnormalities have, however, not been uncovered. Men with TID seem to experience a more pronounced bone loss than their female counterparts. Hence, we aimed to examine different aspects of bone quality in men with T1D. Design and Methods: In this cross-sectional study, men with T1D and healthy, male controls were enrolled. BMD (femoral neck, total hip, lumbar spine, whole body), and spine trabecular bone score (TBS) were measured by dual x-ray absorptiometry, and bone material strength index (BMSi) by in vivo impact microindentation. HbA1c and bone turnover markers were analyzed. Results: Altogether, 33 men with T1D (43 ± 12 yrs) and 28 healthy male controls (42 ± 12 yrs) were included. Subjects with T1D exhibited lower whole body BMD than controls (p=0.04). TBS and BMSi were attenuated in men with T1D vs. controls (p=0.016 and p=0.004, respectively), and T1D subjects also had lower bone turnover. vs. controls. The bone parameters did not differ between subjects with or without diabetic complications. Duration of disease correlated negatively with femoral neck BMD, but not with TBS or BMSi. Conclusions: This study revealed compromised bone material strength and microarchitecture in men with T1D. Moreover, we confirm previous studies showing a modest decrease in BMD and low bone turnover in subjects with T1D, underscoring that bone should be recognized as a target of diabetic complications.

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Section: Discussionsupporting

confidence: 92%