Evaluation of trace element concentration in cancerous and non-cancerous tissues of human stomach

Kohzadi, Shadi; Sheikhesmaili, Farshad; Rahehagh, Ramesh; Parhizkar, Baran; Ghaderi, Ebrahim; Loqmani, Hozan; Shahmoradi, Behzad; Mohammadi, Ebrahim; Maleki, Afshin

doi:10.1016/j.chemosphere.2017.06.071

Cited by 43 publications

(15 citation statements)

References 33 publications

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“…Most GC is induced by a complex interaction between Helicobacter pylori and host factors 3 . Multiple studies have reported that various environmental elements are considered as gastric cancer risk factors including trace elements 4 – 6 . Surgery is the primary therapeutic for GC patients, even with the advances in diagnosis and treatment in the past few years.…”

Section: Introductionmentioning

confidence: 99%

Comprehensive analysis of the expression of SLC30A family genes and prognosis in human gastric cancer

Guo

2020

Sci Rep

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The solute carrier 30 (SLC30) family genes play a fundamental role in various cancers. However, the diverse expression patterns, prognostic value, and potential mechanism of SLC30A family genes in gastric cancer (GC) remain unknown. Herein, we analyzed the expression and survival data of SLC30A family genes in GC patients using multiple bioinformatic approaches. Expression data of SLC30A family genes for GC patients were extracted from the Cancer Genome Atlas (TCGA) and genetic alteration frequency assessed by using cBioportal database. And validated the expression of SLC30A family genes in GC tissues and corresponding normal tissues. The prognostic value of SLC30A family genes in gastric cancer patients were explored using Kaplan–Meier plotter database. Functional enrichment analysis performed using DAVID database and clusterProfiler package. And ssGSEA algorithm was performed to explore the relationship between the SLC30A family genes and the infiltration of immune cells. We found that the median expression levels of SLC30A1-3, 5–7, and 9 were significantly upregulated in gastric cancer tissues compared to non-cancerous tissues, while SLC30A4 was downregulated. Meanwhile, SLC30A1-7, and 9 were significantly correlated with advanced tumor stage and nodal metastasis status, SLC30A5-7, and 9–10 were significantly related to the Helicobacter pylori infection status of GC patients. High expression of five genes (SLC30A1, 5–7, and 9) was significantly correlated with better overall survival (OS), first progression survival (FPS), and post progression survival (PPS). Conversely, upregulated SLC30A2-4, 8, and 10 expression was markedly associated with poor OS, FP and PPS. And SLC30A family genes were closely associated with the infiltration of immune cells. The present study implied that SLC30A5 and 7 may be potential biomarkers for predicting prognosis in GC patients, SLC30A2 and 3 play an oncogenic role in GC patients and could provide a new strategy for GC patients treatment.

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Section: Introductionmentioning

confidence: 99%

Comprehensive analysis of the expression of SLC30A family genes and prognosis in human gastric cancer

Guo

2020

Sci Rep

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“…(13) Higher level of Cu alone was also found significantly higher in cancerous human stomach in compared to normal samples. (14) More importantly, Zn and Cu are known as key cofactors in several enzymes, which include Cu/Zn superoxide dismutases (SODs) decomposing superoxide radicals to H 2 O 2 and playing a significant role against oxidant stress in several DNA repair proteins. (15,16)Previous study has demonstrated that high serum levels of Cu/Zn superoxide dismutase can be related with an increased gastric cancer risk.…”

Section: Introductionmentioning

confidence: 99%

Five Serum Trace Elements Associated with Risk of Cardia and Non-cardia Gastric Cancer in a Matched Case-control Study

Lin

Yan³

et al. 2019

Preprint

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Background : Serum trace elements have been some time suggested to influence the development of gastric cancer, but evidence is still lacking. Methods : In a case-control study from a high risk region of East China, all newly diagnosed patients with gastric cancer were compared with healthy controls 1:1 matched by sex, age (± 3 years) and place of residence during 2013- 2015. Results : A total of 299cases of gastric cancers, which included 122 cases of gastric cardia cancer (GCC) and 177 gastric non-cardia cancer (NCGC), and 299 healthy controls were included. Positive associations were found between serum copper and copper/zinc ratio and risk of overall gastric cancer (OR 4th vs. 1st quartile : 2.42, 95% CI: 1.10-5.32 for copper, p for trend=0.003; OR 4th vs. 1st quartile : 11.7, 95% CI: 3.83-35.6 for copper/zinc ratio, p for trend<0.0001), and for both GCC and NCGC subtypes. Serum selenium inversely associated with risk of NCGC (OR 4th vs. 1st quartile : 0.18, 95% CI: 0.07-0.51, p for trend=0.0001), while molybdenum seem to reduce risk of GCC (OR 4th vs. 1st quartile : 0.12, 95% CI: 0.03-0.47, p for trend<0.0001). Strong inverse associations were also detected between serum calcium and risk of all groups of gastric cancer (all p for trend<0.05). Although intermediate serum level of zinc and iron had lower risk of gastric cancer, no linear association was however found (all p for trend>0.05). Conclusions : The current study present evidences for positive associations between copper, copper/zinc ratio and gastric cancer, as well as for inverse associations between serum selenium, molybdenum and calcium and risk of gastric cancer.

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“…Concentrations of elements in normal tissue, cancerous tissue and its surrounding area were compared 96 . Using ICP-MS the content of Ca, Cu, Fe, As, Mg, Ni, Cd and Cr in stomach tissue taken from patients with cancer was also determined 97 . In turn, Jablonska et al measured the concentrations of Cd, As, Se and Fe in breast cancer tissue 65 .…”

Section: Inductively Coupled Plasma Mass Spectrometry (Icp-ms)mentioning

confidence: 99%

“…Wet sample Brain 19,20,101 , stomach 19,46,97 , liver 19,20,46,77,101,102 , kidney 19,20,46,101,102 , pancreas 20 , spleen 20,101 , heart 19,20 , lung 19 , diaphragm 101 , breast 65 , hair 42,46,64,100 , blood 23,32,46,59,60,81,92 , serum 32,82,83 , amniotic fluid 17 , urine 59,60,102,104 Dry sample Brain 9,45,51,71,72,95,105 , liver 13,…”

Section: Microwave-assisted Acid Digestionmentioning

confidence: 99%

The assessment of the usability of selected instrumental techniques for the elemental analysis of biomedical samples

Planeta

Kubala‐Kukuś

Dróżdż

et al. 2021

Sci Rep

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The fundamental role of major, minor and trace elements in different physiological and pathological processes occurring in living organism makes that elemental analysis of biomedical samples becomes more and more popular issue. The most often used tools for analysis of the elemental composition of biological samples include Flame and Graphite Furnace Atomic Absorption Spectroscopy (F-AAS and GF-AAS), Inductively Coupled Plasma Optical Emission Spectroscopy (ICP-OES) and Inductively Coupled Plasma Mass Spectrometry (ICP-MS). Each of these techniques has many advantages and limitations that should be considered in the first stage of planning the measurement procedure. Their reliability can be checked in the validation process and the precision, trueness and detection limits of elements belong to the most frequently determined validation parameters. The main purpose of this paper was the discussion of selected instrumental techniques (F-AAS, GF-AAS, ICP-OES and ICP-MS) in term of the achieved validation parameters and the usefulness in the analysis of biological samples. The focus in the detailed literature studies was also put on the methods of preparation of the biomedical samples. What is more based on the own data the usefulness of the total reflection X-ray fluorescence spectroscopy for the elemental analysis of animal tissues was examined. The detection limits of elements, precision and trueness for the technique were determined and compared with the literature data concerning other of the discussed techniques of elemental analysis. Reassuming, the following paper is to serve as a guide and comprehensive source of information concerning the validation parameters achievable in different instrumental techniques used for the elemental analysis of biomedical samples.

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Evaluation of trace element concentration in cancerous and non-cancerous tissues of human stomach

Cited by 43 publications

References 33 publications

Comprehensive analysis of the expression of SLC30A family genes and prognosis in human gastric cancer

Comprehensive analysis of the expression of SLC30A family genes and prognosis in human gastric cancer

Five Serum Trace Elements Associated with Risk of Cardia and Non-cardia Gastric Cancer in a Matched Case-control Study

The assessment of the usability of selected instrumental techniques for the elemental analysis of biomedical samples

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