Evaluation of Triple Antibiotic Paste Removal by Different Irrigation Procedures

Berkhoff, Julie; Chen, Paul B.; Teixeira, Fabrício B.; Diogenes, Aníbal

doi:10.1016/j.joen.2013.12.027

Cited by 135 publications

(153 citation statements)

References 41 publications

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“…Despite irrigation, complete removal of TAP and CH has been reported to be difficult. [27] Residues of CH were distributed rather superficially and contained less material, while TAP appeared to have greater retention and deeper penetration. Consequently, residual TAP may lead to the demineralization of dentin via decreasing the pH and chelating the calcium from dentin [11]; demineralized dentin has been reported to be significant in establishing the adhesion of MTA to dentin.…”

Section: Resultsmentioning

confidence: 94%

Effect of medicaments used in endodontic regeneration technique on push-out bond strength of MTA and Biodentine

Türk

Fidler

2015

Biotechnology & Biotechnological Equipment

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The aim of the present study was to evaluate the effect of the intracanal medicaments used in regenerative endodontic treatment on push-out bond strength (PBS) of mineral trioxide aggregate (MTA) and Biodentine (BD). The root canals of 102 maxillary incisors were enlarged to simulate immature roots and were randomly divided into three groups (n D 34): a control group (no intracanal medicament) and two test groups, subjected to calcium hydroxide (CH) or triple antibiotic paste (TAP) medication for two weeks. After the medication removal, each group was divided in two subgroups and the coronal portion of each canal was filled with MTA or BD. After one week of storage, the coronal region of each root was horizontally sectioned and push-out test was performed. Data were analyzed by two-way analysis of variance and the Tukey post hoc test (P D 0.05). PBS values were significantly affected by the type of material (P < 0.001) and the type of medication used (P D 0.049), but no interaction was found (P D 0.97). The BD group showed significantly higher push-out resistance values than those of the MTA group (P < 0.001). TAP showed the lowest PBS values, which were significantly lower than those of the control group (P D 0.043) but not than those of CH (P D 0.229). After a two-week application period, TAP seemed to decrease the PBS of both cements, while CH did not. BD appeared to have higher PBS compared to MTA, regardless of medication.

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Section: Resultsmentioning

confidence: 94%

Effect of medicaments used in endodontic regeneration technique on push-out bond strength of MTA and Biodentine

Türk

Fidler

2015

Biotechnology & Biotechnological Equipment

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“…Therefore, it is expected that dentin previously treated with TAP should be able to release at least 0.3 mg/ mL of TAP to maintain a substantial antibacterial effect at a specific time point. A recent study suggested that 85% of radiolabeled TAP was retained within radicular dentin after various irrigation methods were used (27). It is well documented that various tetracycline derivatives have the ability to bind to dentinal collagen and exert residual antibacterial effects (28,29).…”

Section: A4 A5 A6mentioning

confidence: 99%

Direct and indirect antibacterial effects of various concentrations of triple antibiotic pastes loaded in a methylcellulose system

et al. 2016

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We investigated the direct and indirect(residual) antibacterial effects of various concentrations of triple antibiotic paste (TAP) loaded into a methylcellulose system. Enterococcus faecalis (E. faecalis) was grown on sterilized dentin blocks (n = 60) and treated with clinically used TAP (1,000 mg/ mL), low concentrations of methylcellulose-based TAP (100, 10, and 1 mg/mL), placebo paste, or 1.5% NaOCl (n = 10). The pastes were then removed, and biofilm disruption assays were performed. Additional dentin blocks (n = 120) were pretreated with the same experimental groups (n = 20). The pastes were rinsed off, and the samples were immersed independently in phosphate-buffered saline for 2 and 4 weeks (n = 10). E. faecalis was then grown on the dentin blocks, and biofilm disruption assays were performed. Fisher's Exact and Wilcoxon rank sum tests were used for statistical analyses. With regard to direct antibacterial effects, all treatment groups demonstrated complete eradication of biofilms in comparison to placebo paste, while 10 mg/mL of TAP or higher provided substantial residual antibacterial effects. However, dentin treated with 1 mg/mL of TAP or 1.5% NaOCl did not provide substantial residual antibacterial effects. Dentin pretreated with 10 mg/mL of TAP or higher exhibited extended residual antibacterial effects and can thus be used during endodontic regeneration. (J Oral Sci 58, 575-582, 2016)

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“…4,25,26 Although CH is a widely used intracanal antibacterial medicament 6 , root canal infection is considered polymicrobial, thus CH is not entirely sufficient as a disinfectant. Accordingly, various broadspectrum antibiotic pastes have been developed to provide more efficient antimicrobial treatments.…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, most of the CH was adequately removed. 26 Arslan et al also showed that it was difficult to remove TAP from the canals, even when using different irrigation solutions. 29 Tanase et al reported that minocycline binds to calcium ions via chelation to form an insoluble complex in the tooth matrix.…”

Section: Discussionmentioning

confidence: 99%

Impact of Intracanal Calcium Hydroxide or Triple Antibiotic Paste on Bond Strength of Root Canal Sealers: An In Vitro Study

Gündoğar¹

2017

Cumhuriyet Dental Journal

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A B S T R A C TObjectives:The aim of this study is to compare the effects of intracanal treatments with calcium hydroxide (CH) or triple antibiotic paste (TAP) on bond strength of a calcium silicate-based sealer (MTA Fillapex) and an epoxy resin-based sealer (MM Seal). Materials and Methods:Sixty extracted maxillary central incisors were prepared with a rotary system to size 40. The specimens were randomly divided into two groups, which received either intracanal CH or TAP. After rinsing, the teeth in each group were further divided into two additional groups, which were obturated with gutta percha and either the MTA Fillapex or MM Seal root canal sealer. Then, slices were obtained from three sections of the canal (coronal, middle, and apical). A push-out test was performed to measure the bond strength between the root canal dentin and the sealer.Results: The push-out bond strengths of the root canal sealers were significantly affected by the type of intracanal medicament. Both the sealers showed bond strengths that were nearly two-fold higher after TAP application than after CH application, and these results were independent of the position along the canal. Conclusions:The use of TAP rather than CH improves the bond strength of calcium silicate-and epoxy resin-based sealers throughout the root canal.

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Evaluation of Triple Antibiotic Paste Removal by Different Irrigation Procedures

Cited by 135 publications

References 41 publications

Effect of medicaments used in endodontic regeneration technique on push-out bond strength of MTA and Biodentine

Effect of medicaments used in endodontic regeneration technique on push-out bond strength of MTA and Biodentine

Direct and indirect antibacterial effects of various concentrations of triple antibiotic pastes loaded in a methylcellulose system

Impact of Intracanal Calcium Hydroxide or Triple Antibiotic Paste on Bond Strength of Root Canal Sealers: An In Vitro Study

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