Evaluation of two devices for point-of-care testing of haemoglobin in neonatal pigs

Kutter, Annette P N; Mauch, Jacqueline; Riond, Barbara; Martin-Jurado, Olga; Spielmann, Nelly; Weiß, Markus; Bettschart‐Wolfensberger, Regula

doi:10.1258/la.2011.011086

Cited by 22 publications

(7 citation statements)

References 37 publications

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“…Portable blood analyzers provide easy access to real-time results within minutes and are used for acid-base and electrolyte balance diagnoses with therapeutic and prognostic implications in humans [ 5 , 6 ] and small animals [ 7 – 9 ]. However, they have only been proposed recently as a useful tool for the early assessment of the health status in nursery pigs [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Blood parameters as biomarkers in a Salmonella spp. disease model of weaning piglets

et al. 2017

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BackgroundThe weaning pig is used as an experimental model to assess the impact of diet on intestinal health. Blood parameters (BP) are considered a useful tool in humans, but there is very scarce information of such indicators in the weaning pig. The objective of the present study is to evaluate the use of different BP as indicators in an experimental model of salmonellosis.MethodologySeventy-two 28-day-old piglets were divided into four groups in a 2x2 factorial arrangement, with animals receiving or not a probiotic combination based on B. infantis IM1® and B. lactis BPL6 (109 colony forming units (cfu)/d) and orally challenged or not a week later with Salmonella Typhimurium (5x108 cfu). Blood samples of one animal per pen (N = 24) were taken four days post-inoculation for the evaluation of different BP using an I-stat® System and of plasmatic concentrations of zinc, iron and copper.Principal findingsResults reported marginal deficiencies of zinc in piglets at weaning. Moreover, plasmatic zinc, copper and iron presented good correlations with weight gain (r 0.57, r -0.67, r 0.54 respectively; P < 0.01). Blood electrolytes (Na+, Cl- and K+) decreased (P < 0.01) only when the performance of the animals was seriously compromised and clinical symptoms were more apparent. Acid-base balance parameters such as HCO3-, TCO2 and BEecf significantly correlated with weight gain, but only in the challenged animals (r -0.54, r -0.55, and r -0.51, respectively; P < 0.05), suggesting metabolic acidosis depending on Salmonella infection. Glucose was affected by the challenge (P = 0.040), while Htc and Hgb increased with the challenge and decreased with the probiotic (P < 0.05). Furthermore, correlations of Glu, Htc and Hgb with weight gain were observed (P < 0.05). Overall, BP could be regarded as simple, useful indexes to assess performance and health of weaning piglets.

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Section: Introductionmentioning

confidence: 99%

Blood parameters as biomarkers in a Salmonella spp. disease model of weaning piglets

et al. 2017

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“…The haemoglobin concentration was analysed with a HemoCue 201 + Hb photometer (HemoCue AB, Ängelholm, Sweden). The device is developed for the use in human medicine but has been validated for the use in pigs, with an intra-assay coefficient of 1.1 to 2.2% [ 18 ]. According to the operating manual, the system is factory-calibrated against the haemiglobincyanide (HiCN) method, the international reference method for the determination of the haemoglobin concentration in blood and hence, no further calibration was needed.…”

Section: Methodsmentioning

confidence: 99%

Iron status in piglets at three days of age and at weaning and possible seasonal effects on the blood haemoglobin levels in a Swedish outdoor pig-producing farm

Fjelkner,

Sannö,

Emanuelson

2024

Acta Vet Scand

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Background Piglets are born with limited stores of iron, and with an increasing number of live-born piglets, there may be a risk that the sows cannot provide enough iron to their offspring. The iron content in soil may not meet the demands of today’s piglet, born and reared in an outdoor setting. The study aimed to describe the blood haemoglobin (Hb) levels in pigs reared outdoors and to determine whether piglets have higher Hb levels at weaning when an iron supplement is administered intramuscularly at three days of age, as compared to pigs not given an iron supplement. The seasonal variation in Hb-levels was also to be investigated. The Hb concentration was analysed with a HemoCue 201 + Hb photometer. Results In total 56 litters (399 piglets) were included in the study and sampled at three days of age, while 378 piglets were sampled at weaning. The mean Hb level at three days of age was 91 g/L (48–154 g/L). In total 47% of the piglets had Hb levels < 90 g/L at three days of age. The mean Hb level at weaning was 127 g/L (76–176 g/L), with a lower level (122 g/L) in the group given the iron supplement than in the group not given an iron supplement (132 g/L). Only 1% of the piglets had Hb levels lower than 90 g/L at weaning. Results indicative of a seasonal effect on Hb levels at three days of age was demonstrated. Piglets born in spring had significantly lower Hb levels, and piglets born in autumn had significantly higher Hb levels. No seasonal effect could be demonstrated for Hb levels at day 33. Conclusions The results indicate that the natural uptake from the environment was sufficient, but that there was a seasonal effect on the Hb levels at three days of age. This indicates that there might be a need for different routines regarding iron supplementation in outdoor reared piglets depending on the climate and season.

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“…Blood was obtained from an ear vein with a 20-gauge needle, loaded into a 10 µL microcuvette, and processed in a HemoCue Hb 201. 2,5 This instrument was factory calibrated against the International Council for Standardization in Haematology reference method for Hb concentration and did not need further calibration. Litter demographics (number of live born, stillborn, and mummies) also were recorded for each sow.…”

Section: Methodsmentioning

confidence: 99%

Late gestation hemoglobin concentrations in sows: Predictor for stillborn piglets

Noblett¹,

Ferriera²,

Bhattarai³

et al. 2021

JSHAP

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Evaluation of two devices for point-of-care testing of haemoglobin in neonatal pigs

Cited by 22 publications

References 37 publications

Blood parameters as biomarkers in a Salmonella spp. disease model of weaning piglets

Blood parameters as biomarkers in a Salmonella spp. disease model of weaning piglets

Iron status in piglets at three days of age and at weaning and possible seasonal effects on the blood haemoglobin levels in a Swedish outdoor pig-producing farm

Late gestation hemoglobin concentrations in sows: Predictor for stillborn piglets

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