Evaluation of two novel macrocycles containing pyridine-2,6-dicarboxamide unit as cationic fluorescent sensor

In the present study, a series of cardo‐type novel polyimides (PI)s containing xanthene groups was synthesized. All the polymers were amorphous in nature with inherent viscosities in the range of 0.72–0.91 dl/g. Study of thermal behavior showed that PIs have excellent thermal stability with 10% weight loss at temperatures (Td10%) between 426 and 528 °C, glass transition‐related temperatures (Tg) in the range of 292–305 °C, and weight residual at 700 °C ranged from 55% to 68% under N2 atmosphere. Xanthene and fluorene presence, progressed the PIs solubility and also induced good biological activities. The in vitro anticancer activity of the 6FD‐derived PI against the A431 (epidermoid carcinoma) cells showed an IC50 value of 29.3 μM. In the next part of the work, a polymer‐based composite (PI‐B/m‐TiO2@HBP) was prepared by inscribing 20 wt% of hyperbranched polyamide‐grafted TiO2 nanoparticles into BTDA‐derived PI‐B matrix, and compared with the unfilled PI, its photoluminescence intensity and thermal stability properties were increased. The PI‐B and nanocomposite exhibited good antibacterial activity against six bacterial strains. In the following, study of methylene blue (MB) dye adsorption from aqueous solution by the obtained PIs and PI‐B/HBP@TiO2 was carried out and removal efficiency values were found above 80.62%.

show abstract

“…All the tests were carried out in triplicate. The values of IC 50 were determined after 2 days 46,47 …”

Section: Methodsmentioning

confidence: 99%

Novel cardo‐type heat‐resistant polyimides bearing 9H‐xanthene and polymer‐based nanocomposite consisting of NH₂‐terminated TiO₂: Synthetic strategies, extraction of methylene blue dye, and biological activities

Khaki

Namazi

Amininasab

2022

Journal of Polymer Science

View full text Add to dashboard Cite

show abstract

Unveiling the promising anticancer effect of copper-based compounds: a comprehensive review

Abdolmaleki,

Aliabadi,

Khaksar

2024

J Cancer Res Clin Oncol

View full text Add to dashboard Cite

Copper is a necessary micronutrient for maintaining the well-being of the human body. The biological activity of organic ligands, especially their anticancer activity, is often enhanced when they coordinate with copper(I) and (II) ions. Copper and its compounds are capable of inducing tumor cell death through various mechanisms of action, including activation of apoptosis signaling pathways by reactive oxygen species (ROS), inhibition of angiogenesis, induction of cuproptosis, and paraptosis. Some of the copper complexes are currently being evaluated in clinical trials for their ability to map tumor hypoxia in various cancers, including locally advanced rectal cancer and bulky tumors. Several studies have shown that copper nanoparticles can be used as effective agents in chemodynamic therapy, phototherapy, hyperthermia, and immunotherapy. Despite the promising anticancer activity of copper-based compounds, their use in clinical trials is subject to certain limitations. Elevated copper concentrations may promote tumor growth, angiogenesis, and metastasis by affecting cellular processes.

show abstract

Synthesis and Characterization of Chitosan-Based Hydrogels Grafted Polyimidazolium as Nitrate Ion Adsorbent from Water and Investigating Biological Properties

Amininasab,

Adim,

Abdolmaleki

et al. 2024

J Polym Environ

View full text Add to dashboard Cite

Evaluation of two novel macrocycles containing pyridine-2,6-dicarboxamide unit as cationic fluorescent sensor

Cited by 23 publications

References 60 publications

Novel cardo‐type heat‐resistant polyimides bearing 9H‐xanthene and polymer‐based nanocomposite consisting of NH₂‐terminated TiO₂: Synthetic strategies, extraction of methylene blue dye, and biological activities

Novel cardo‐type heat‐resistant polyimides bearing 9H‐xanthene and polymer‐based nanocomposite consisting of NH₂‐terminated TiO₂: Synthetic strategies, extraction of methylene blue dye, and biological activities

Unveiling the promising anticancer effect of copper-based compounds: a comprehensive review

Synthesis and Characterization of Chitosan-Based Hydrogels Grafted Polyimidazolium as Nitrate Ion Adsorbent from Water and Investigating Biological Properties

Contact Info

Product

Resources

About

Evaluation of two novel macrocycles containing pyridine-2,6-dicarboxamide unit as cationic fluorescent sensor

Cited by 23 publications

References 60 publications

Novel cardo‐type heat‐resistant polyimides bearing 9H‐xanthene and polymer‐based nanocomposite consisting of NH2‐terminated TiO2: Synthetic strategies, extraction of methylene blue dye, and biological activities

Novel cardo‐type heat‐resistant polyimides bearing 9H‐xanthene and polymer‐based nanocomposite consisting of NH2‐terminated TiO2: Synthetic strategies, extraction of methylene blue dye, and biological activities

Unveiling the promising anticancer effect of copper-based compounds: a comprehensive review

Synthesis and Characterization of Chitosan-Based Hydrogels Grafted Polyimidazolium as Nitrate Ion Adsorbent from Water and Investigating Biological Properties

Contact Info

Product

Resources

About

Novel cardo‐type heat‐resistant polyimides bearing 9H‐xanthene and polymer‐based nanocomposite consisting of NH₂‐terminated TiO₂: Synthetic strategies, extraction of methylene blue dye, and biological activities

Novel cardo‐type heat‐resistant polyimides bearing 9H‐xanthene and polymer‐based nanocomposite consisting of NH₂‐terminated TiO₂: Synthetic strategies, extraction of methylene blue dye, and biological activities