2018
DOI: 10.1016/j.jevs.2016.09.014
|View full text |Cite
|
Sign up to set email alerts
|

Evaluation of Two Protocols Using Autologous Conditioned Serum for Intra-articular Therapy of Equine Osteoarthritis—A Pilot Study Monitoring Cytokines and Cartilage-Specific Biomarkers

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

2
28
0
1

Year Published

2018
2018
2023
2023

Publication Types

Select...
9

Relationship

0
9

Authors

Journals

citations
Cited by 26 publications
(31 citation statements)
references
References 33 publications
2
28
0
1
Order By: Relevance
“…Due to a lack of robust clinical data, in vitro data that highlight mechanisms of action cannot be overlooked. In addition, there are few studies that directly compare different cell-based therapies for OA ( 30 , 36 38 ), and foundational information such as optimum processing and storage methods, as well as safe and effective doses and dosing regimens, are inconclusive ( 21 , 22 , 39 , 40 ). Therefore, critical analysis of available information as well as a thorough understanding of key therapeutic elements of cell-based therapies is essential for the practitioner and researcher alike.…”
Section: Cell-based Therapies Currently Used In Dogs and Horses For Jmentioning
confidence: 99%
See 1 more Smart Citation
“…Due to a lack of robust clinical data, in vitro data that highlight mechanisms of action cannot be overlooked. In addition, there are few studies that directly compare different cell-based therapies for OA ( 30 , 36 38 ), and foundational information such as optimum processing and storage methods, as well as safe and effective doses and dosing regimens, are inconclusive ( 21 , 22 , 39 , 40 ). Therefore, critical analysis of available information as well as a thorough understanding of key therapeutic elements of cell-based therapies is essential for the practitioner and researcher alike.…”
Section: Cell-based Therapies Currently Used In Dogs and Horses For Jmentioning
confidence: 99%
“…The injection frequency of ACS is likely important. Horses with arthroscopically defined naturally occurring OA treated with three injections of IRAP II™ at 2-day intervals had significantly lower levels of IL-1β, biomarkers of cartilage degradation, and IL-1Ra 42 days after treatment initiation compared with horses injected at 7-day intervals ( 22 ). Despite clinical improvements, in vitro studies have not demonstrated chondroprotective effects and it is likely that mitigation of inflammation is mainly responsible for reduction in lameness and cartilage degradation.…”
Section: Blood-derived Productsmentioning
confidence: 99%
“…6,7,9,11,17,21,25 Modern biologicals, such as mesenchymal stem cells (MSC), platelet-rich plasma, and autologous conditioned serum, provide only modest benefits. [26][27][28][29][30][31] Notably, intra-articular corticosteroids block the inflammatory reaction and are known to have detrimental effects on cartilage metabolism more damaging than simply chondrocyte quiescence, antagonizing common cellular pathways innately required for efficient tissue homeostasis and repair (eg, IL-10, prostaglandin, and NF-kB). 32,33 Two goals are important in achieving progress toward the treatment of OA 1 : promotion of an inflammatory response that efficiently clears pro-inflammatory triggers 2 ; preservation of cellular and tissue mechanisms involved in joint physiology.…”
Section: Introductionmentioning
confidence: 99%
“…In humans, PGE 2 has been shown to sensitize nociceptor neurons (49). Therefore, downregulation of this protein may explain the clinical improvement in observed lameness in horses treated with ACS or APS (9,12,28,50).…”
Section: Discussionmentioning
confidence: 99%