Evaluation of Using Mineralized Plasmatic Matrix in Osseous Regeneration (Experimental and Histomorphometric Study on Rabbits)

Ghanem, Marwa A.; Sharara, Ahmed A.; Sweedan, Ahmed; Khalil, Nesma M.

doi:10.21608/adjalexu.2018.57994

Cited by 4 publications

(3 citation statements)

References 16 publications

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“…PRP is the first form of autologous platelet concentrate to replace commercial fibrin glue. A major disadvantage of PRP though is the risk of coagulopathies due to the use of bovine thrombin that is needed during the preparation stage 19) . The second-generation platelet concentrate, PRF, eliminated this risk since it does not need anticoagulants for its preparation.…”

Section: Discussionmentioning

confidence: 99%

Implant Stability, Bone Graft Loss and Density with Conventional and Mineralized Plasmatic Matrix Bone Graft Preparations - A Randomized Crossover Trial

Sghaireen

Alzarea

Alam

et al. 2020

J. Hard Tissue Biology.

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This study aimed to compare implant stability, bone loss, and bone density using the mineralized plasmatic matrix (MPM) and conventional bone grafting methods. Patients were recruited in a stratified sample and each received 2 implants one at each side of their upper jaws. MPM was randomly placed in the surgical site around one implant on one side while a conventional graft, was placed on the other side in a cross-over design clinical trial. A total of 84 implants were placed in 42 patients. A total of 42 implants utilized conventional grafts (GM1) and a total of 42 implants utilized mineralized plasmatic matrix (GM2). Mean Perio test measurements for implants in the group (GM1) were lower than that for implants in the group (GM2) (1.21±3.0 versus 3.57±2.9). Mean radiographic density at grafted sites with GM2 was: 665.2±236.5 whereas for GM1 it was: 577.8±201.2. Implant stability with MPM in males was significantly higher than females (P<0.001). Bone graft loss with MPM in males was significantly less than females (P=0.001). There were no differences between older and younger patients regarding implant stability, bone loss, and bone density (P>0.05). It is concluded that utilizing MPM in implants may be associated with better implant treatment outcomes of implant stability, bone graft loss, and density when compared to conventional bone grafts. Gender but not age differences may be noticed when comparing implant stability and bone graft loss in implants utilizing MPM.

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Section: Discussionmentioning

confidence: 99%

Implant Stability, Bone Graft Loss and Density with Conventional and Mineralized Plasmatic Matrix Bone Graft Preparations - A Randomized Crossover Trial

Sghaireen

Alzarea

Alam

et al. 2020

J. Hard Tissue Biology.

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“…Before any surgery, the rabbits' cheeks were shaved, and to prevent contamination, the skin was washed and cleansed with povidoneiodine (Betadine) (El-Nile Co., Egypt) (14). And because maximal precision was mandatory, definite dimensions (2 cm in length) were drawn using a ruler to determine the outline of the incision.…”

Section: Animals Preparationmentioning

confidence: 99%

“…Following successful euthanasia, a scalpel (Aesculap, Inc., USA) was used to remove representative scar sections, and care was taken to involve the deep layers of the skin. All specimens were labelled and fixed for one day in 10% neutral buffered formalin, after which segments that contained the surgical sites were dissected and left for five days in the same fixation (16). Histological procedures (13) Following fixation, specimens were cleaned, dehydrated in ethanol solutions with increasing ethanol concentrations, cleared with xylene, infiltrated, and embedded in paraffin wax.…”

Section: Group (B) Controlmentioning

confidence: 99%

Effect of Botulinum Toxin on Surgical Wound Healing and Scar Formation (An Experimental Study)

Abd El-Gawad,

Mohamed,

Raslan

et al. 2024

Alexandria Dental Journal

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INTRODUCTION:The process of wound healing is complicated. Despite research, hypertrophic scars still occur and can pose functional and aesthetic issues. Improvement for hypertrophic scars has been attained using a variety of treatment modalities. The strain from the underlying muscles working on the wound edge throughout the healing process is a critical factor in shaping the scar's final appearance. Since botulinum toxin type A (BTA) causes total muscle paralysis, it was suggested as a possible treatment. OBJECTIVES: To evaluate the effect of BTA injection on the final appearance of the surgical scar. MATERIALS AND METHODS: Thirty-six mature male New Zealand rabbits weighing 3.5-4 kg were studied experimentally (one year of age). They were divided into two groups: One received BTA injections into the cheek muscles surrounding a Y-shaped surgical incision. The other group received no further treatment after the incision. A follow-up was performed after 2, 4, and 6 weeks for the assessment of the scar parameters (wound width and Vancouver scar scale (VSS), along with clinical photographs). After each period, the sacrifice group of rabbits was done. Samples were prepared for histological and histomorphometric analysis by being dissected. RESULTS: When compared to the control group, the BTA-treated group showed an improvement in the appearance of scars, VSS and a reduced increase in wound width. Histological and histomorphometric results indicate that the BTA group had a better layout and less collagen deposition than the control group. CONCLUSIONS: BTA injection effectively reduced collagen fibril production and improved hypertrophic scar appearance.

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Secondary alveolar cleft grafting using autogenous mineralized plasmatic matrix (MPM) versus cancellous bone particles derived from anterior iliac crest

2023

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Objective The essential concern of alveolar cleft grafting in patients of cleft lip and palate at the mixed dentition phase is to gain bone within the cleft area that provides closure of the oronasal communication with continuous and stable maxilla for future cleft teeth eruption or implantation. This study aimed to compare the effectiveness of mineralized plasmatic matrix (MPM) versus cancellous bone particles harvested from anterior iliac crest in secondary alveolar cleft grafting. Patients and methods This prospective randomized controlled trial was conducted on ten patients with unilateral complete alveolar cleft requiring cleft reconstruction. Patients were randomly divided into two equal groups; group (1) included 5 patients who received particulate cancellous bone derived from anterior iliac crest (control group) and group (2) included 5 patients who received MPM graft prepared from cancellous bone derived from anterior iliac crest (study group). All patients received CBCT preoperatively, immediately postoperatively and after 6 months. On the CBCT, graft’s volume, labio-palatal width, and height were measured and compared. Results The outcome of the studied patients 6 months postoperatively showed that the control group had significant decrease in the graft volume, labio-palatal width, and height compared to the study group. Conclusion MPM allowed for the integration of bone graft particles inside a fibrin network, which offers positional stability of the bone particles, thus preserving their shape with subsequent “in situ” immobilization of the graft components. This conclusion was reflected positively in terms of maintained graft volume, width, and height compared to that of the control group. Clinical relevance MPM allowed for maintenance of grafted ridge volume, width, and height.

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Evaluation of Using Mineralized Plasmatic Matrix in Osseous Regeneration (Experimental and Histomorphometric Study on Rabbits)

Cited by 4 publications

References 16 publications

Implant Stability, Bone Graft Loss and Density with Conventional and Mineralized Plasmatic Matrix Bone Graft Preparations - A Randomized Crossover Trial

Implant Stability, Bone Graft Loss and Density with Conventional and Mineralized Plasmatic Matrix Bone Graft Preparations - A Randomized Crossover Trial

Effect of Botulinum Toxin on Surgical Wound Healing and Scar Formation (An Experimental Study)

Secondary alveolar cleft grafting using autogenous mineralized plasmatic matrix (MPM) versus cancellous bone particles derived from anterior iliac crest

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