Evaluation of vagus nerve function before and after antireflux surgery

Effect of Vagus Nerve Injury on the Outcome of Antireflux Surgery: An Extensive Literature Review

“…In the 8 studies selected for this review, data were reported on a total of 893 patients [24,25,26,27,28,29,30,31]. In all studies, 2 groups were compared: one in which vagus nerve integrity was maintained and one with VNI.…”

“…The 2 remaining studies reported on unintended, accidental VNI objectively measured by the response of pancreas polypeptide to insulin-induced hypoglycemia (PP-IH) or to sham feeding PP-SF) [21,22,24,25]. Different operative techniques were used in the 8 selected studies: laparoscopic TF (LTF), TF, laparoscopic NF (LNF), NF, AF, hill posterior gastropexy (HPG), HHR and Lortat Jacobs fundopexia (LJF).…”

“…Only 2 studies assessed unintended VNI objectively by the response of PP-SF or PP-IH [24,25] (table 3). …”

“…DeVault et al [25] assessed VNI using the PP-SF test. After an overnight fast, 2 baseline blood samples were obtained from the patients.…”

“…Lindeboom et al [24] reported a VNI prevalence of 10% (4/41) 6 months after LTF in a prospective cohort. In the study by DeVault et al [25,] 20 patients were assessed prior to and 1 week after LNF. Among the patients with a normal PP response in the preoperative state (n = 12), an abnormal postoperative test result was seen in 5 patients (42%; table 4).…”