Evaluation of ventriculomegaly using diffusion tensor imaging: correlations with chronic hydrocephalus and atrophy

Osuka, Satoru; Matsushita, Akira; Yamamoto, Tetsuya; Saotome, Kousaku; Isobe, Takeshi; Nagatomo, Yasushi; Masumoto, T.; Komatsu, Yoji; Ishikawa, Eiichi; Matsumura, Akira

doi:10.3171/2009.7.jns09550

Cited by 44 publications

(51 citation statements)

References 24 publications

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“…9,16,41,45,48,55,57,59,75,84,94,125 Understanding the periventricular white matter tracts is helpful not only in defining more precise surgical strategies, but also in clarifying the symptoms of and appropriate treatment for patients with hydrocephalus and periventricular lesions. 11,18,36,38,40,47,50,52,58,65,66,76,80,101 This study examines the tracts at risk in the 3 surgical routes-anterior, posterior, and lateral-to the lateral ventricle. The anterior approaches include the anterior interhemispheric transcallosal, anterior frontal transcortical, and anterior frontal interhemispheric transrostral; the posterior approaches include the posterior transcortical (superior parietal lobule), posterior interhemispheric transcallosal, posterior interhemispheric precuneal, supracere- …”

Section: Discussionmentioning

confidence: 99%

“…This can be explained by its rigid composition. 76 Additionally, Lundin et al found a significant decrease in total N-acetyl compounds and Nacetyl aspartate in the thalamus of NPH patients compared with healthy groups in an MR spectroscopy study. Total N-acetyl and N-acetyl aspartate are related with neuronal density.…”

Section: Caudate Nucleusmentioning

confidence: 99%

“…However, in NPH the posterior part of the corona radiata fibers may have increased FA (compressed but without secondary damage). 76 The anterior part of the corona radiata, positioned around the frontal horns, will be affected first, followed by the posterior part, relatively far from the frontal horns. 40,50 Increased FA in the posterior part of the corona radiata suggests a shunt-responsive NPH, as differentiated from other dementias.…”

Section: Corona Radiatamentioning

confidence: 99%

“…MR tractography has been recommended as a means of differentiating among NPH, AD, and PD. 36,38,40,47,50,52,65,66,76 Hydrocephalus studies have suggested that the compression indicated by high fractional anisotropy (FA) levels will eventually cause the neuronal degeneration, brain edema, or deterioration of the white matter indicated by low FA levels.…”

Section: Periventricular Tracts In Hydrocephalusmentioning

confidence: 99%

“…Osuka et al reported higher caudate nucleus FA values that increased rapidly after surgery in NPH patients compared with the atrophy group, and they suggested that evaluation of caudate nucleus FA values can be used to differentiate NPH from other diseases. 76 Changes in the construction of the human caudate by hydrocephalus or dementia can result in a variety of neurological and psychiatric disorders. 34,85 Thalamus…”

Section: Caudate Nucleusmentioning

confidence: 99%

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The white matter tracts of the cerebrum in ventricular surgery and hydrocephalus

Güngör¹,

Baydın²,

Middlebrooks

et al. 2017

JNS

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S urgical approaches to the lateral ventricle always require passage through one and often multiple fiber tracts to reach their target. These approaches remain a challenge because of the deep location and variable shape and size of the ventricles, their covering mantle of tracts, and relationships to important neural structures such as the thalamus and internal capsule. 55,75,84 In addition, a number of tracts course in the walls of the ventricle where they are separated from the cerebrospinal fluid by only a thin layer of ependyma and would likely be exposed to the greatest possibility of damage by hydrocephalus.84,124 Recent studies have focused on the relationships of the fiber tracts to eloquent cortical areas and avoiding the optic radiations in approaches to the lateral ventricle. 16,41,48,59,63,75,89,92,94,125 The aim of the present study was to explore the relationships of the tracts to the lateral ventricles and the various surgical approaches to the ventricles and to examine the anatomy and syndromes related to ventricular enlargement. MethodsForty adult human formalin-fixed cadaveric hemispheres (20 brains) were examined under magnification that ranged from ×6 to ×40. The dura, pia, arachnoid, and surface vessels were gently removed. All specimens were frozen in water for at least 2 weeks at -16°C, as described by Klingler, to separate the tracts and facilitate dissection. 51 After freezing, the specimens were thawed and rinsed of formalin under tap water for at least 1 hour. Prior OBJECTIVEThe relationship of the white matter tracts to the lateral ventricles is important when planning surgical approaches to the ventricles and in understanding the symptoms of hydrocephalus. The authors' aim was to explore the relationship of the white matter tracts of the cerebrum to the lateral ventricles using fiber dissection technique and MR tractography and to discuss these findings in relation to approaches to ventricular lesions. METHODS Forty adult human formalin-fixed cadaveric hemispheres (20 brains) and 3 whole heads were examined using fiber dissection technique. The dissections were performed from lateral to medial, medial to lateral, superior to inferior, and inferior to superior. MR tractography showing the lateral ventricles aided in the understanding of the 3D relationships of the white matter tracts with the lateral ventricles. RESULTS The relationship between the lateral ventricles and the superior longitudinal I, II, and III, arcuate, vertical occipital, middle longitudinal, inferior longitudinal, inferior frontooccipital, uncinate, sledge runner, and lingular amygdaloidal fasciculi; and the anterior commissure fibers, optic radiations, internal capsule, corona radiata, thalamic radiations, cingulum, corpus callosum, fornix, caudate nucleus, thalamus, stria terminalis, and stria medullaris thalami were defined anatomically and radiologically. These fibers and structures have a consistent relationship to the lateral ventricles. CONCLUSIONS Knowledge of the relationship of the white matter tracts o...

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