Evaluation of Ves‐Matic Cube 200 For Erythrocyte Sedimentation Rate Determination

Abstract

Ves-Matic Cube 200 should be monitored carefully for good quality control. Temperature correction should be applied to study control material as recommended by the manufacturer. Ves-Matic Cube 200 device should be monitored carefully, performance studies should be performed, and the results should be checked in order to eliminate the random errors during the routine studies.

Comparison of iSED and Ves‐Matic Cube 200 Erythrocyte Sedimentation Rate Measurements With Westergren Method

“…Hemolysis caused a significant decrease in ESR levels for the Ves‐Matic Cube 200 method ( P = 0.005), though there has not been a significant difference in the measurement of ESR for the iSED method ( P = 0.766) with hemolysis. Sezer et al found that presence of lipids and hemolysis caused falsely low ESR measurements in the Ves‐Matic Cube 200 analyzer and that was in accordance with our findings.…”

“…Systematic bias for the Ves‐Matic Cube 200 was found to be higher in increscent ESR levels (mean bias of low levels = −6.2, mean bias of medium levels = 0.6, mean bias of high levels = 16.7). Sezer et al reported systemic bias as −0.7 and limits of agreement as −32.6 to 31.2; Perovic reported the bias as −0.5, limits of agreement −13.9 to 12.9 in the Ves‐Matic Cube 200 analyzer and Westergren method comparison study .…”

“…Perovic et al reported CVs for Ves‐MaticCube 200 analyzers as 9.19%, 13.88%, and 5.66% . Sezer et al had evaluated the Ves‐Matic Cube 200 system and reported CVs as 14.01%, 14.99%, and 5.69% for low, medium, and high ESR levels, respectively. Happe et al evaluated the precision for Diesse Mini‐Ves (DMV) and reported that precision decreased substantially in low ESR levels (CVs: 30.4%; ).…”

“…The high ESR results can be observed in various infectious diseases, infarctions, malignancies, and autoimmune diseases . The increase in ESR is nonspecific for many diseases , but the levels of ESR are markedly elevated in polymyalgia rheumatica and temporal arteritis (often higher than 100 mm/hr), which can be specifically used for diagnose and follow‐up .…”

Analytical validation of the iSED automated analyzer for erythrocyte sedimentation rate

“…Hereby, we demonstrated a much better precision of iSED with commercial control samples at both evaluated levels than in a previously published study, while patient samples yielded intrarun CVs similar to already reported data for iSED, with decreasing precision at medium and low ESR levels This is in concordance with data from a lot of validation studies of automated ESR analyzers, regardless of the analyzer type and measurement principle and can be attributed to small numbers rather than poor analytical performance, therefore not being considered clinically significant.…”