Evaluation of visual pathways using visual evoked potentials in the patients with impaired fasting glucose and impaired glucose tolerance

Korkmaz, Tuğba; Kısabay, Ayşın; Hekimsoy, Zeliha; Şenol, Emel; Selçuki, Deniz

doi:10.1080/00207454.2018.1495631

Cited by 2 publications

(2 citation statements)

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“…This is consistent with a previous study reporting a positive correlation of P100 latency in GDM with the glycemic status of subjects [14]. A study by Korkmaz et al reported prolonged P100 latency in glucose intolerant or pre-diabetic subjects as compared to normoglycemic controls, reflecting that P100 latency can be affected by milder forms of hyperglycemia than well-established diabetes [22]. Within the GDM group, women receiving insulin therapy reported longer mean P100 latencies during baseline and late pregnancy than women placed on diet therapy.…”

Section: Discussionsupporting

confidence: 92%

Assessment of Visual Evoked Potential to Detect Visual Pathway Dysfunction in Gestational Diabetes Mellitus: A Longitudinal Case-Control Study With Post-partum Follow-up

Kapila Sharma,

Mohan,

Mittal

et al. 2023

Cureus

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Background: The increasing prevalence of gestational diabetes mellitus (GDM) during pregnancy has opened the opportunity to study its short-and long-term effects on maternal ophthalmic health. Visual evoked potential (VEP) is a non-invasive electrophysiological test that detects functional disturbances along the visual pathway before the physical signs of diabetic retinopathy (DR) can set in. This longitudinal study is aimed at the assessment of changes in VEP in GDM during different stages of pregnancy and 6-12 weeks after parturition by comparing it with normoglycemic controls.Design and method: Diagnosed cases of GDM were recruited along with normoglycemic controls at 24-28 weeks of gestation. Each participant was required to attend two follow-up appointments at 32-38 weeks of gestation and 6-12 weeks after parturition. A blood sample was taken in a fasting state to record biochemical parameters. VEP was recorded using Neuropack S1 MEB-9400 electrodiagnostic equipment (Nihon Kohden, Tokyo, Japan) in a dark room by providing pattern reversal stimuli to each eye.Results: A total of 29 participants (15 in the control group and 14 in the GDM group) completed the entire study procedure. The observed mean P100 latency of both eyes in the GDM group was recorded longer as compared to that in the control group at baseline and during late pregnancy. Although the mean P100 latency saw a significant decline in postpartum visits as compared to that in late pregnancy, the values were higher than in the control group. P100 latency at baseline correlated significantly to serum advanced glycated end products' (AGE'S) levels in the GDM group. Conclusion:Our study findings reflect that the diagnosis of GDM is associated with significant changes in VEP during and after pregnancy as compared to that of healthy pregnant women.

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Section: Discussionsupporting

confidence: 92%

Assessment of Visual Evoked Potential to Detect Visual Pathway Dysfunction in Gestational Diabetes Mellitus: A Longitudinal Case-Control Study With Post-partum Follow-up

Kapila Sharma,

Mohan,

Mittal

et al. 2023

Cureus

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“…Korkmaz dkk meneliti aplikasi VEP pada pasien dengan GDP terganggu, namun tidak ditemukan peningkatan latensi P100 dibanding kontrol yang signifikan. 22 Hasil yang berbeda dilaporkan Rajewski dkk, bahwa pemanjangan latensi P100 memiliki hubungan yang signifikan dengan peningkatan GDP atau HbA1c pada pasien DMT2. [23][24] Rerata latensi P100 lebih panjang dibandingkan dengan pasien yang memiliki kontrol glikemik yang baik.…”

Section: Variabelunclassified

Peran Visual Evoked Potential Pada Pasien Diabetes Melitus Tipe-2 Dengan Dan Tanpa Retinopati Diabetik

Tanawal

Tumboimbela

Mahama

2018

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ROLE OF VISUAL EVOKED POTENTIAL IN TYPE-2 DIABETES MELLITUS WITH AND WITHOUT DIABETIC RETINOPATHYABSTRACTIntroduction: Diabetic retinopathy (DR) is a common complication of type-2 diabetes mellitus (T2DM). Minimal functional change of neural layers of the retina occurs before structural changes, thus undetected by funduscopy. This damage could be identified earlier by P100 latency changes in visual evoked potential (VEP).Aims: To find the characteristic of P100 in T2DM with and without DR, its correlation with the duration of thedisease and the level of fasting blood glucose (FBG).Methods: A cross sectional analysis study was conducted in Prof. dr. R.D. Kandou Hospital, Manado, from November2017-January 2018. T2DM patients aged 18-60 with visual acuity >6/60, without neuro-ophtalmological disorders and other metabolic diseases. P100 latency was measured using VEP with reversed checkerboard stimulation.Results: There were 56 subjects with T2DM, mostly were females (57,1%) and age mean was 54,86±5,65 years. Delayed P100 latency occurred in 85,7% subjects. Diabetic retinopathy subjects showed delayed P100 latency on right (92,31%) and left (88%) eyes while T2DM subjects without retinopathy showed delayed P100 latency on both eyes 70%. There were strong and significant positive correlation between the duration of T2DM and P100 latency on the right and left eyes. There was no significant correlation between fasting blood glucose (FBG) level and P100 latency.Discussions: Delayed P100 latency occurs in T2DM patients with and without retinopathy. The duration of T2DMcorrelates with the delay of P100 latency but not with the level of FBG.Keywords: Diabetic retinopathy, P100, type-2 diabetes mellitus, visual evoked potential ABSTRAKPendahuluan: Retinopati diabetik adalah suatu komplikasi yang umum terjadi pada diabetes melitus tipe-2 (DMT2). Sebelum terjadinya perubahan struktural, lapisan neuron retina pasien DMT2 sudah mengalami perubahan fungsional minimal yang tidak terdeteksi dengan funduskopi. Hal ini dapat diidentifikasi lebih dini berdasarkan gambaran latensi gelombang P100 pada pemeriksaan visual evoked potential (VEP).Tujuan: Untuk mengetahui karakteristik nilai gelombang P100 pada pasien DMT2 dengan dan tanpa retinopati diabetik, serta hubungannya dengan lama penyakit dan kadar glukosa darah puasa (GDP).Metode: Penelitian analitik dengan desain potong lintang terhadap pasien DMT2 yang dirawat di RSUP Prof. dr. R.D. Kandou, Manado periode November 2017-Januari 2018. Subjek berusia 18-60 tahun dengan visus >6/60 tanpa adanya kelainan neuro-oftamologi dan penyakit metabolik lain. Dilakukan perekaman VEP menggunakan stimulasi reversed checkerboard dilanjutkan pengukuran latensi gelombang P100.Hasil: Didapatkan 56 subjek, paling banyak perempuan (57,1%) dan rerata usia 54,86±5,65 tahun. Latensi P100 memanjang pada 85,7% subjek. Pada subjek dengan retinopati ditemukan mayoritas mengalami pemanjangan latensi pada mata kanan (92,31%) dan mata kiri (88%), sedangkan pada subjek tanpa retinopati ditemukan pemanjangan latensi kedua mata adalah 70%. Terdapat hubungan bermakna dengan korelasi positif kuat antara lamanya DMT2 dan latensi P100 kanan dan kiri. Tidak terdapat hubungan yang bermakna antara kadar GDP dan latensi P100.Diskusi: Pemanjangan latensi P100 terjadi pada subjek DMT2 dengan dan tanpa retinopati. Lamanya DMT2 berhubungan dengan pemanjangan latensi P100, tetapi kadar GDP tidak berhubungan dengan pemanjangan latensi P100.Kata kunci: Diabetes melitus tipe-2, P100, retinopati diabetik, visual evoked potential

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Evaluation of visual pathways using visual evoked potentials in the patients with impaired fasting glucose and impaired glucose tolerance

Abstract: It was observed that VEP may be a parameter of predictive value that might be used in evaluating prediabetic cases in terms of retinopathies similar to DM.

Cited by 2 publications

References 28 publications

Assessment of Visual Evoked Potential to Detect Visual Pathway Dysfunction in Gestational Diabetes Mellitus: A Longitudinal Case-Control Study With Post-partum Follow-up

Assessment of Visual Evoked Potential to Detect Visual Pathway Dysfunction in Gestational Diabetes Mellitus: A Longitudinal Case-Control Study With Post-partum Follow-up

Peran Visual Evoked Potential Pada Pasien Diabetes Melitus Tipe-2 Dengan Dan Tanpa Retinopati Diabetik

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