Evaluation Of Weight Changes On Wistar Rats Induced By Erythromycin And Aqueous Neem Leaves ExtractEvaluation Of Weight Changes On Wistar Rats Induced By Erythromycin And Aqueous Neem Leaves Extract

Abstract

Objective: To evaluate weight changes on the liver of male (albino wistar) rats induced by erythromycin. To assess the outcome of aqueous Neem leaf extract on erythromycin induced hepatic injuries. Methodology: Eighty male albino wistar rats were taken randomly and were divided into 4 groups of 20 animals each. Group A as a control group. Group B rats were treated with erythromycin drug. Group C rats were treated with erythromycin along with Aqueous Neem leaves extract. Group D were given only Aqueous Neem leaves extract. Body weight of animals was recorded initially and also after experimentation. After 14 days animals were sacrificed, liver weight was also recorded. Results: The liver of erythromycin treated animals group B were little bigger in size and more reddish. However erythromycin plus Neem treated animals of group C livers were almost like liver of control group A and only Neem given group D animals, liver were exactly same appearance like control group A.Rise in absolute and relative weight of liver was because of drug toxicity. Conclusion: Its established from this recent study that Aqueous Neem leaves extract being a powerful antioxidant, decreased oxidative stress and hepatic injury caused by erythromycin.