Evaluation of Workers’ Exposure to Methylene Diphenyl Diisocyanate (MDI) in an Automobile Manufacturing Company, Iran

Kakooei, Hossein; Shahtaheri, Seyed Jamaled­din; Karbasi, Hossein-Ali

doi:10.1080/10803548.2006.11076701

Cited by 4 publications

(2 citation statements)

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“…Whereas Maitre et al (1993) have measured a value of 12 μmol/mol creatinine for HDI exposure at the same concentration from a separate survey of workers. In a developing country, the above situations reinforced the reasons why Kakooei et al (2006) had expressed the importance of studying indoor air pollution in such industries. For the imported technology and the machinery used without suitable application of adequate engineering controls and proper safe work practice together with the levels of training and awareness can cause great exposure to air pollutants and may result in more occupational health problems than in the developed countries.…”

Section: Hdi and Hda Relationship In The Factoriesmentioning

confidence: 99%

Evaluation of Hexamethylene Diisocyanate as an Indoor Air Pollutant and Biological Assessment of Hexamethylene Diamine in the Polyurethane Factories

Mirmohammadi¹,

Ibrahim²,

Saraji³

2011

Advanced Air Pollution

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Section: Hdi and Hda Relationship In The Factoriesmentioning

confidence: 99%

Evaluation of Hexamethylene Diisocyanate as an Indoor Air Pollutant and Biological Assessment of Hexamethylene Diamine in the Polyurethane Factories

Mirmohammadi¹,

Ibrahim²,

Saraji³

2011

Advanced Air Pollution

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“…However, occupational exposure to NCO is often a mixture of monomers and oligomers so there is some uncertainty in the comparison of the results of the biological control of exposure (4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14) . Biological markers have relatively short half-lives in urine, 2-5 hours, which means that urine samples must be collected at the end of exposure and results mainly reflect exposure on the day of collection (14) , halflives in plasma are usually longer (20-25 days), Sabbioni et al have shown that methylenediphenyl diisocyanate (MDI) forms adducts with lysine in plasma albumin and may offer a potential for assessing risk (16)(17) . All the volunteer studies and occupational studies with both air and biological monitoring show good correlations between exposure, mostly inhalation, and levels of biomarkers in urine or blood and advocate the usefulness of biological monitoring.…”

Section: Introductionmentioning

confidence: 99%

Current framework of suicide and suicidal ideation in health professionals

2014

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Introduction: Technological development has led to the use of chemicals potentially damaging to workers' health. In particular, the use of isocyanates has resulted in a greater morbidity caused by respiratory pathology, especially asthma. Considering that not all the exposed workers develop the disease, a geneenvironment interaction model has been proposed, which tries to explain the genetic predisposition that some individuals have and others have not to develop occupational asthma. Objective: To find out about the scientific evidence related to the genetic polymorphism and workers exposed to isocyanates' susceptibility to develop occupational asthma. Methods: We conducted a systematic review. Bibliographic electronic searches were conducted in PubMedline databases, as well as in Dialnet and ELSEVIER repositories. Papers related to this review's objective were retrieved, without applying temporary filters, using the following descriptors: MeSH Major Topic, MeSH Terms. Search period started on November 20 th 2013 and ended on December 15 th 2013. We established the level of evidence according to GRADE criteria. Results: Forty-two full-text papers were analyzed, scientific evidence being supported by eleven casecontrol studies. Given the complexity of the genetic polymorphism associated with disease phenotype, as a

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Methylene diphenyl diisocyanate occupational exposure data in industry (1998–2020): A descriptive summary from an industrial hygiene perspective

Spence¹,

Plehiers²,

George

et al. 2023

Toxicol Ind Health

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This paper provides an overview of airborne methylene diphenyl diisocyanate (MDI) concentrations in workplaces across North America and Europe. A total of 7649 samples were collected between 1998 and 2020 by producers of MDI during product stewardship activities at customer sites, primarily using validated OSHA or ISO sampling and analysis techniques. As would be expected from the low vapor pressure of MDI, 80% of the concentrations were less than 0.01 mg/m3 (1 ppb) and 93% were less than 0.05 mg/m3 (5 ppb). Respiratory protection is an integral part of Industrial Hygiene practices; therefore, its use was studied and summarized. While covering a variety of MDI applications, a large number of samples was obtained from composite wood manufacturing facilities, offering specific insight into potential exposures associated with different process sections and job types in this industry sector. Given the potential presence in industrial processes of MDI-containing dust or aerosols, future work should place increased emphasis on also investigating dermal exposure. The data reported in this paper provide valuable information for product stewardship and industrial hygiene purposes throughout the MDI-processing industry.

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Evaluation of Workers’ Exposure to Methylene Diphenyl Diisocyanate (MDI) in an Automobile Manufacturing Company, Iran

Abstract: Evaluation of personal inhalation exposure to methylene diphenyl diisocyanate (MDI) among

Cited by 4 publications

References 12 publications

Evaluation of Hexamethylene Diisocyanate as an Indoor Air Pollutant and Biological Assessment of Hexamethylene Diamine in the Polyurethane Factories

Evaluation of Hexamethylene Diisocyanate as an Indoor Air Pollutant and Biological Assessment of Hexamethylene Diamine in the Polyurethane Factories

Current framework of suicide and suicidal ideation in health professionals

Methylene diphenyl diisocyanate occupational exposure data in industry (1998–2020): A descriptive summary from an industrial hygiene perspective

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