Evaluation on composition, antioxidant and toxicity of Melaleuca cajuputi leaves

Noor, Arif Azimi Md; Yusuf, Siti Mahirah; Wahab, Wan Nor Amilah Wan Abdul; Adam, Faizul Ismal Che; Sul’ain, Mohd Dasuki

doi:10.1007/s13596-020-00479-x

Cited by 10 publications

(12 citation statements)

References 50 publications

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“…Different medicinal plants are known to contain diverse natural compounds, which could be exploited for various purposes in different fields (Dawood et al, 2021; Lee et al, 2020; Van Hai, 2015). The presence of terpenoids, sesquiterpenes, polyphenolic ketones, flavonoids, 1,8‐cineole, and other phenolic and aromatic compounds in MCLE is consistent with previous research by Yoshimura et al (2008), Jajaei et al (2010), Sakasegawa and Yatagai (2003), Al‐Abd et al (2015) and Noor et al (2021). This study observed that 2‐Isopropyl‐10‐methylphenanthrene was the major compound in the MCLE extract.…”

Section: Discussionsupporting

confidence: 92%

“…On the contrary, the decreasing value of CF and FCR in prawns with the increasing percentage of MCLE-enriched diet proved that there was no exhibition of anti-nutritional factors which could reduce nutrient utilization or food intake in treated prawns(Soetan and Oyewole, 2009). The findings are consistent with the suggestion made byZahran et al (2014) that the lower the value of FCR, the better the diet consumption returns to a good weight gain Noor et al (2021). had earlier shown that the methanol extract of MCLE is toxic based on the Meyer's and Clarkson's classification.…”

supporting

confidence: 91%

“…The findings are consistent with the suggestion made by Zahran et al (2014) that the lower the value of FCR, the better the diet consumption returns to a good weight gain. Noor et al (2021) had earlier shown that the methanol extract of MCLE is toxic based on the Meyer's and Clarkson's classification. Notwithstanding, no mortality was recorded in the current study with increase in the concentrations of the MCLE extract, hence suggestive that the highest level used could have been below the level capable of causing death to the prawn.…”

Section: Discussionmentioning

confidence: 99%

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Cajeput Melaleuca cajuputi extract supplementation in diets of Macrobrachium rosenbergii : Insight on the growth, immunological responses and resistance against Aeromonas hydrophila

Sahimi

Nagi

Hamdan

et al. 2022

Aquaculture Research

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Shrimp consumption has increased steadily around the world, as has the emergence of bacterial pathogens, which cause massive economic losses. The incorporation of plant extracts in aquatic animal feeds has been suggested to improve growth performance and resistance against bacterial pathogens. Therefore, the aim of this study was to evaluate the effects of Cajeput Melaleuca cajuputi leaf extract (MCLE) on the growth performance, physiological responses and resistance of Giant freshwater prawn Macrobrachium rosenbergii against Aeromonas hydrophila. The phytochemical composition of the MCLE was analysed using gas chromatography–mass spectrometry (GC‐MS). Thereafter, the MCLE was included in diets (0.0, 5.0, 10.0 and 15.0 g/kg) fed to the M. rosenbergii. The growth was observed after 45 days of the feeding trial, whereas physiological responses and clearance efficiency (%) against A. hydrophila were observed on the 60th day. 2‐Isopropyl‐10‐methylphenanthrene, phenanthrene, 1‐methyl‐7‐(1‐methyl ethyl) and 4H‐1‐Benzopyran‐4‐one, 3‐acetyl‐5, 7‐dihydroxy‐2‐methyl‐ compounds were detected as the major compounds in the MCLE. A significant improvement (p < 0.05) of growth and survival of M. rosenbergii fed with MCLE supplementation at 15.0 g/kg was observed. The total haemocyte count, hyaline cells and granular cells were also increased (p < 0.05) in the M. rosenbergii fed with diets included with MCLE. Upon challenging the primed M. rosenbergii with sub‐lethal doses of A. hydrophila, the highest clearance efficiency (73%) was achieved in the prawn‐fed 15.0 g/kg MCLE based diet (p < 0.05) after 96 h post injection. These findings indicate the potential of MCLE supplementation to improve growth, immune responses of M. rosenbergii and their resistance against A. hydrophila.

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Section: Discussionsupporting

confidence: 92%

supporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

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Cajeput Melaleuca cajuputi extract supplementation in diets of Macrobrachium rosenbergii : Insight on the growth, immunological responses and resistance against Aeromonas hydrophila

Sahimi

Nagi

Hamdan

et al. 2022

Aquaculture Research

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“…In the GC-MS analysis, 37 compounds were detected in MCLE, with terpenes and flavonoids being the major compounds. Terpenes such as caryophyllene oxide (2.07%), 1H-imidazole, 4,5-diphenyl-18.60%, 2-isopropyl-10-methylphenanthrene (13.50%), and stigmasterol (1.02%) are among the higher peaks found in MCLE, which have also been reported previously ( Noor et al . 2021 ; Białoń et al .…”

Section: Discussionsupporting

confidence: 86%

“…Some of them demonstrated their toxicity through acute toxicity tests ( Jayakumar et al . 2020 ; Noor et al . 2021 ; Bakar 2020 ; Roszaini et al .…”

Section: Introductionmentioning

confidence: 99%

Histopathological Alterations in Gills, Liver and Kidney of African Catfish (Clarias gariepinus, Burchell 1822) Exposed to Melaleuca cajuputi Extract

Marina Hassan,

Anuar Abdalah Nagi Melad,

Mohd Ihwan Zakariah

et al. 2023

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This study evaluated the histopathological changes in the gill, liver and kidney of African catfish (Clarias gariepinus) intoxicated with a sub-lethal dose of Melaleuca cajuputi leaves extract (MCLE) for 96 h. The acute toxicity test has been determined previously with a value of 96-h LC50 = 127 mg/L, hence the selection of sub-lethal ranges from 60 mg/L to 160 mg/L of MCLE. Degenerative alterations were prominent in all tested organs, particularly after exposure to a high concentration of MCLE. Gill exhibited haemorrhage, epithelial lifting, lamellar disorganisation, and necrosis after exposure to a high MCLE concentration. Alterations in the liver include congestion, hydropic degeneration, and vacuolation, whereas lesions in the kidney were pyknosis, vacuolation, hydropic degeneration, and tubular necrosis. The obtained data showed that the organs experienced severe changes proportional to the increase in MCLE concentration. In addition, fish exposed to higher concentrations than the LC50 value experienced irreversible lesions. The present study suggests that the use of MCLE below the LC50 is recommended to avoid severe alterations to organs, particularly in African catfish. This study demonstrated that the use of MCLE above the LC50 promotes severe damage to the gills, liver and kidney of African catfish. However, further investigations are needed to define the causing-mechanisms underlying these effects.

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Exploring the Therapeutic Potential of Terpenoids for Depression and Anxiety

Noor

2024

Chemistry & Biodiversity

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This review focus on the terpenoids as potential therapeutic agents for depression and anxiety disorders, which naturally found in a variety of plants and exhibit a wide range of biological activities. Among the terpenoids discussed in this review are α‐pinene, β‐caryophyllene, α‐phellandrene, limonene, β‐linalool, 1, 8‐cineole, β‐pinene, caryophyllene oxide, p‐cymene, and eugenol. All of these compounds have been studied extensively regarding their pharmacological properties, such as neuroprotective effect, anti‐inflammation, antibacterial, regulation of neurotransmitters and antioxidant effect. Preclinical evidence are reviewed to highlight their diverse mechanisms of action and therapeutic potential to support antidepressant and anxiolytic properties. Additionally, challenges and future directions are also discussed to emphasize therapeutic utility of terpenoids for mental health disorders. Overall, this review provides a promising role of terpenoids as novel therapeutic agents for depression and anxiety, with potential implications for the development of more effective and well‐tolerated treatments in the field of psychopharmacology.

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Evaluation on composition, antioxidant and toxicity of Melaleuca cajuputi leaves

Cited by 10 publications

References 50 publications

Cajeput Melaleuca cajuputi extract supplementation in diets of Macrobrachium rosenbergii : Insight on the growth, immunological responses and resistance against Aeromonas hydrophila

Cajeput Melaleuca cajuputi extract supplementation in diets of Macrobrachium rosenbergii : Insight on the growth, immunological responses and resistance against Aeromonas hydrophila

Histopathological Alterations in Gills, Liver and Kidney of African Catfish (Clarias gariepinus, Burchell 1822) Exposed to Melaleuca cajuputi Extract

Exploring the Therapeutic Potential of Terpenoids for Depression and Anxiety

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