Evaluation the Effectiveness of Phenolic Compound of Salvia Frigida on Induced Atopic Dermatitis in Experimental Mice

Abstract

Abstract
 To evaluate the effectiveness of Phenolic Compound of Salvia Frigida on induced atopic dermatitis (AD) of mice. Forty mice were included in the study, divided in to four groups (10 mice/group): apparently healthy, induced AD without treatment, induced AD treated with tacrolimus 0.1% ointment, and induced AD treated with Phenolic Compound of Salvia Frigida cream 5%. Examination of histopathology was done and skin homogenates levels also measured. Levels of WBC, Eosinophil, skin tissue homogenate of IL-13 and IL-4, serum IgE, and histopathological scores were significantly increased among induced non treated AD group in comparison with control group. Comparisons of non-treated induced AD group with Salvia Frigida or Tacrolimus treated groups; shows a significant reduction in the levels of all studied parameters’ (WBC, Eosinophil, skin tissue homogenate of IL4- and IL-13, serum IgE, observational severity score, and histopathological scores) after the application of Tacrolimus 0.1% ointment. While after application of phenolic compound cream 5%, its shows a significant reduction in the levels of all parameters except these of (eosinophil, IgE, and IL-13). Comparison between the effect of topical application of tacrolimus and phenolic compound on the studied variables shows that the levels of epidermal thickness was significantly lower after application of phenolic compound among studied groups, while the levels of WBC and inflammatory cell were significantly lower after application of tacrolimus among studied groups. Using of these therapeutic agents that targeting IgE, IL-4 and IL-13 will probably useful in treatment of AD.

Mitigative Effects of Topical Norfloxacin on an Imiquimod-Induced Murine Model of Psoriasis

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Ethnobotanical, Phytochemical, and Pharmacological Properties of the Subfamily Nepetoideae (Lamiaceae) in Inflammatory Diseases

“…Br., and S. sclareoides Brot. reduced the enzymatic activity of elastase and inflammatory mediator molecules, such as nitric oxide (NO), IL-4, IL-13, IL-5, TNF-α, cyclooxygenase (COX)-2, and prostaglandine PGE2 in RAW 264.7 macrophages induced with LPS in organic extracts of different polarities and aqueous extracts [65][66][67][68][69][70]. The polar extracts of S. chudei Batt.…”

“…In the case of Salvia, terpenes of abietane, clerodane, labdane, and pimarane-type structures have been described. Some examples are tanshinone IIA (C14) and sclareol (C15) isolated from S. miltiorrhiza and S. sclarea, respectively [61][62][63][64][65][66][67][68][69][70][71]. In the case of the genus Isodon, compounds with a Kaurano-type skeleton predominated, and some common cases among the species were adenanthine (C16), eriocalyxin B (C17), and oridonine (C18) [114,117,169].…”