Event-related potential patterns and gender effects underlying facial affect processing in schizophrenia patients

Lee, Seung Hwan; Kim, Eun Young; Kim, Sangrae; Bae, Sung‐Man

doi:10.1016/j.neures.2010.03.001

Cited by 59 publications

(83 citation statements)

References 66 publications

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“…This contrasts with the prominent evidence of reduced amplitudes of ERP/ERF responses in ScZ, especially in chronic ScZ patients (Onitsuka et al, 2006;Lee et al, 2010). In addition, given the aberrant perceptual learning during repetition suppression, a process that implicates NMDARs (Schmidt et al, 2013b), our results are potentially compatible with abnormal glutamatergic neurotransmission during the early stages of psychosis.…”

Section: Discussioncontrasting

confidence: 90%

“…Sensor-level M100 and M170 responses were intact in FE-ScZ, which contrasts with previous studies in chronic ScZ reporting reduced ERP responses during face processing (Lee et al, 2010). The only difference for sensor-level ERF components was observed for the M250, which has been related to closure processes during perception of fragmentary/incomplete visual information (Doniger et al, 2002).…”

Section: Aberrant Network Activity In Scz Patients During Mooney Facecontrasting

confidence: 99%

“…In addition to important insights into normal brain functioning, ERPs/ERFs have been used to identify aberrant cortical processes in schizophrenia (ScZ;Luck et al, 2011). These studies have revealed impairments both in the latency and amplitude of ERP/ERF components for early, sensorydriven potentials, such as the P50 (Freedman et al, 1983) and P/M100 (Doniger et al, 2002), and later components, such as N/M170 (Herrmann et al, 2004) and P/M300 (Ford, 1999), which are involved in higher cognitive functions such as face processing and decision making (Onitsuka et al, 2006;Lee et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

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Source-Reconstruction of Event-Related Fields Reveals Hyperfunction and Hypofunction of Cortical Circuits in Antipsychotic-Naive, First-Episode Schizophrenia Patients during Mooney Face Processing

et al. 2014

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Schizophrenia is characterized by dysfunctions in neural circuits that can be investigated with electrophysiological methods, such as EEG and MEG. In the present human study, we examined event-related fields (ERFs), in a sample of medication-naive, first-episode schizophrenia (FE-ScZ) patients (n ϭ 14) and healthy control participants (n ϭ 17) during perception of Mooney faces to investigate the integrity of neuromagnetic responses and their experience-dependent modification. ERF responses were analyzed for M100, M170, and M250 components at the sensor and source levels. In addition, we analyzed peak latency and adaptation effects due to stimulus repetition. FE-ScZ patients were characterized by significantly impaired sensory processing, as indicated by a reduced discrimination index (AЈ). At the sensor level, M100 and M170 responses in FE-ScZ were within the normal range, whereas the M250 response was impaired. However, source localization revealed widespread elevated activity for M100 and M170 in FE-ScZ and delayed peak latencies for the M100 and M250 responses. In addition, M170 source activity in FE-ScZ was not modulated by stimulus repetitions. The present findings suggest that neural circuits in FE-ScZ may be characterized by a disturbed balance between excitation and inhibition that could lead to a failure to gate information flow and abnormal spreading of activity, which is compatible with dysfunctional glutamatergic neurotransmission.

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Section: Discussioncontrasting

confidence: 90%

Section: Aberrant Network Activity In Scz Patients During Mooney Facecontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Source-Reconstruction of Event-Related Fields Reveals Hyperfunction and Hypofunction of Cortical Circuits in Antipsychotic-Naive, First-Episode Schizophrenia Patients during Mooney Face Processing

et al. 2014

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“…Additionally, in this study, patients with schizophrenia, but not normal controls, showed a significant association between right posterior FG reduction and N170 reduction to faces but not to other objects at right posterior temporal electrodes. It has been repeatedly reported that patients with schizophrenia showed reduced N170 amplitudes to neutral and emotional faces (Caharel et al, 2007;Campanella et al, 2006;Lee et al, 2010;Lynn & Salisbury, 2008;Obayashi et al, 2009;Turetsky et al, 2007). However, the effects of facial emotional expressions on N170 still remain controversial.…”

Section: N170mentioning

confidence: 99%

New Findings for Face Processing Deficits in the Mental Disorder of Schizophrenia

Onitsuka¹,

Tsunoda²,

Ohara³

2011

Face Analysis, Modeling and Recognition Systems

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“…People with severe psychiatric disorders, such as schizophrenia, were characterized by impaired neural activity in response to BSF faces (Couture, Penn, & Roberts, 2006;Lee, Kim, Kim, & Bae, 2010;Turetsky et al, 2007). We did not expect that level of neural impairment in a normal population.…”

Section: The Present Studymentioning

confidence: 93%

Individual differences in cardiac vagal tone are associated with differential neural responses to facial expressions at different spatial frequencies: An ERP and sLORETA study

Park¹,

Moon²,

Kim

et al. 2012

Cogn Affect Behav Neurosci

Self Cite

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A previous study has shown that greater cardiac vagal tone, reflecting effective self-regulatory capacity, was correlated with superior visual discrimination of fearful faces at high spatial frequency Park et al. (Biological Psychology 90:171-178, 2012b). The present study investigated whether individual differences in cardiac vagal tone (indexed by heart rate variability) were associated with different event-related brain potentials (ERPs) in response to fearful and neutral faces. Thirty-six healthy participants discriminated the emotion of fearful and neutral faces at broad, high, and low spatial frequencies, while ERPs were recorded. Participants with low resting heart rate variability-characterized by poor functioning of regulatory systems-exhibited significantly greater N200 activity in response to fearful faces at low spatial frequency and greater LPP responses to neutral faces at high spatial frequency. Source analyses-estimated by standardized low-resolution brain electromagnetic tomography (sLORETA)-tended to show that participants with low resting heart rate variability exhibited increased source activity in visual areas, such as the cuneus and the middle occipital gyrus, as compared with participants with high resting heart rate variability. The hyperactive neural activity associated with low cardiac vagal tone may account for hypervigilant response patterns and emotional dysregulation, which heightens the risk of developing physical and emotional problems.

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Event-related potential patterns and gender effects underlying facial affect processing in schizophrenia patients

Cited by 59 publications

References 66 publications

Source-Reconstruction of Event-Related Fields Reveals Hyperfunction and Hypofunction of Cortical Circuits in Antipsychotic-Naive, First-Episode Schizophrenia Patients during Mooney Face Processing

Source-Reconstruction of Event-Related Fields Reveals Hyperfunction and Hypofunction of Cortical Circuits in Antipsychotic-Naive, First-Episode Schizophrenia Patients during Mooney Face Processing

New Findings for Face Processing Deficits in the Mental Disorder of Schizophrenia

Individual differences in cardiac vagal tone are associated with differential neural responses to facial expressions at different spatial frequencies: An ERP and sLORETA study

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