Event‐related potentials during sustained attention and memory tasks: Utility as biomarkers for mild cognitive impairment

Waninger, Shani; Berka, Chris; Meghdadi, Amir H.; Karić, Marija Stevanović; Stevens, Kimberly T.; Agüero, Cinthya; Sitnikova, Tatiana; Salat, David H.; Verma, Ajay

doi:10.1016/j.dadm.2018.05.007

Cited by 29 publications

(31 citation statements)

References 37 publications

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“…Although a significant number of studies have investigated the ERPs, research has not been systematically conducted, and the results have not been consistent (Evans and Federmeier, 2007; Eve et al, 2018; Waninger et al, 2018). A study has reported that the P200 wave and the late positive complex are sensitive to changes in task attention and WM requirements (Smith et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Decreased Information Replacement of Working Memory After Sleep Deprivation: Evidence From an Event-Related Potential Study

et al. 2019

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Working memory (WM) components are altered after total sleep deprivation (TSD), both with respect to information replacement and result judgment. However, the electrophysiological mechanisms of WM alterations following sleep restriction remain largely unknown. To identify such mechanisms, event-related potentials were recorded during the n-back WM task, before and after 36 h sleep deprivation. Thirty-one young volunteers participated in this study and performed a two-back WM task with simultaneous electroencephalography (EEG) recording before and after TSD and after 8 h time in bed for recovery (TIBR). Repeated measures analysis of variance revealed that, compared to resting wakefulness, sleep deprivation induced a decrease in the P200 amplitude and induced longer reaction times. ERP-component scalp topographies results indicated that such decrease primarily occurred in the frontal cortex. The N200 and P300 amplitudes also decreased after TSD. Our results suggest that decreased information replacement of WM occurs after 36 h of TSD and that 8 h TIBR after a long period of TSD leads to partial restoration of WM functions. The present findings represent the EEG profile of WM during mental fatigue.

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Section: Introductionmentioning

confidence: 99%

Decreased Information Replacement of Working Memory After Sleep Deprivation: Evidence From an Event-Related Potential Study

et al. 2019

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“…The LPC is thought to reflect memory encoding and retrieval, especially for explicit recognition memory, and is often calculated as the difference between old and new trials (i.e., old/new effect). LPC also indexes semantic and syntactic processing, and SYSTEMATIC REVIEW OF COGNITIVE ERPS IN MCI AND AD 26 the LPP component reported significantly smaller LPP amplitudes in MCI compared to HC groups[16,116,146]. All three of these studies are very recent (i.e., 2016-2018), suggesting the need for future research with this component.…”

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confidence: 99%

A systematic review of cognitive event-related potentials in mild cognitive impairment and Alzheimer’s disease

Paitel

Samii

Nielson

2021

Behavioural Brain Research

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This systematic review examined whether event-related potentials (ERPs) during higher cognitive processing can detect subtle, early signs of neurodegenerative disease. Original, empirical studies retrieved from PsycINFO and PubMed were reviewed if they analyzed patterns in cognitive ERPs (³150ms post-stimulus) differentiating mild cognitive impairment (MCI), Alzheimer's disease (AD), or cognitively intact elders who carry AD risk through the Apolipoprotein-E ε4 allele (ε4+) from healthy older adult controls (HC). The 100 studies meeting inclusion criteria (MCI=47; AD=47; ε4+=6) analyzed N200, P300, N400, and occasionally, later components. While there was variability across studies, patterns of reduced amplitude and delayed latency were apparent in pathological aging, consistent with AD-related brain atrophy and cognitive impairment. These effects were particularly evident in advanced disease progression (i.e., AD > MCI) and in later ERP components measured during complex tasks. Although ERP studies in intact ε4+ elders are thus far scarce, a similar pattern of delayed latency was notable, along with a contrasting pattern of increased amplitude, consistent with compensatory neural activation. This limited work suggests ERPs might be able to index early neural changes indicative of future cognitive decline in otherwise healthy elders. As ERPs are also accessible and affordable relative to other neuroimaging methods, their addition to cognitive assessment might substantively enhance early identification and characterization of neural dysfunction, allowing opportunity for earlier differential diagnosis and targeting of intervention. To evaluate this possibility there is urgent need for well-powered studies assessing late cognitive ERPs during complex tasks, particularly in healthy elders at risk for cognitive decline.

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“…Bad drivers exhibit impaired ability to maintain focus, improper allocation of attention, and are more easily distracted. In a separate study in which 3CVT EEG ERP biomarkers were evaluated in patients with a neurodegenerative disease affecting memory (amnestic MCI), no P200 differences were observed compared to healthy controls (Waninger et al, 2018). These amnestic MCI patients did not present with noticeable attentional deficits.…”

Section: Discussionmentioning

confidence: 99%

“…This study investigated the use of simultaneous electroencephalogram (EEG) and electrocardiogram (ECG) measurement in a population of healthy participants and HIV+ patients (>55 years old) during a test of sustained attention and processing speed. The combination of EEG, ECG, and behavioral performance metrics derived from the 3CVT were previously proven highly sensitive and specific in quantifying daytime drowsiness associated either with sleep deprivation in healthy participants or in sleep disordered patients, predicting susceptibility to sleep deprivation, and assessing neurocognitive deficits in patients with Parkinson's disease (PD), AD, MCI, and sleep disorders (Westbrook et al, 2002; Berka et al, 2006, 2007, 2009; Pojman et al, 2009a,b; Johnson et al, 2010, 2011; Waninger et al, 2018). The 3CVT evaluates sustained attention, visuospatial processing speed, and decision-making.…”

Section: Introductionmentioning

confidence: 99%

EEG-Based Neurocognitive Metrics May Predict Simulated and On-Road Driving Performance in Older Drivers

Rupp

Berka

Meghdadi

et al. 2019

Front. Hum. Neurosci.

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The number of older drivers is steadily increasing, and advancing age is associated with a high rate of automobile crashes and fatalities. This can be attributed to a combination of factors including decline in sensory, motor, and cognitive functions due to natural aging or neurodegenerative diseases such as HIV-Associated Neurocognitive Disorder (HAND). Current clinical assessment methods only modestly predict impaired driving. Thus, there is a need for inexpensive and scalable tools to predict on-road driving performance. In this study EEG was acquired from 39 HIV+ patients and 63 healthy participants (HP) during: 3-Choice-Vigilance Task (3CVT), a 30-min driving simulator session, and a 12-mile on-road driving evaluation. Based on driving performance, a designation of Good/Poor (simulator) and Safe/Unsafe (on-road drive) was assigned to each participant. Event-related potentials (ERPs) obtained during 3CVT showed increased amplitude of the P200 component was associated with bad driving performance both during the on-road and simulated drive. This P200 effect was consistent across the HP and HIV+ groups, particularly over the left frontal-central region. Decreased amplitude of the late positive potential (LPP) during 3CVT, particularly over the left frontal regions, was associated with bad driving performance in the simulator. These EEG ERP metrics were shown to be associated with driving performance across participants independent of HIV status. During the on-road evaluation, Unsafe drivers exhibited higher EEG alpha power compared to Safe drivers. The results of this study are 2-fold. First, they demonstrate that high-quality EEG can be inexpensively and easily acquired during simulated and on-road driving assessments. Secondly, EEG metrics acquired during a sustained attention task (3CVT) are associated with driving performance, and these metrics could potentially be used to assess whether an individual has the cognitive skills necessary for safe driving.

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Event‐related potentials during sustained attention and memory tasks: Utility as biomarkers for mild cognitive impairment

Cited by 29 publications

References 37 publications

Decreased Information Replacement of Working Memory After Sleep Deprivation: Evidence From an Event-Related Potential Study

Decreased Information Replacement of Working Memory After Sleep Deprivation: Evidence From an Event-Related Potential Study

A systematic review of cognitive event-related potentials in mild cognitive impairment and Alzheimer’s disease

EEG-Based Neurocognitive Metrics May Predict Simulated and On-Road Driving Performance in Older Drivers

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