Event-related potentials for the diagnosis of mild cognitive impairment and Alzheimer's disease

Kimiskidis, Vasilios Κ.; Papaliagkas, Vasileios

doi:10.1517/17530059.2012.634795

Cited by 12 publications

(7 citation statements)

References 89 publications

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“…There exists a strong foundation suggesting the utility of ERPs as quantitative biomarkers of cognitive processes [4] , [5] , [9] , [10] , [11] , [13] , [14] , [15] . ERPs reveal abnormal neuronal activity in AD beginning in the very early stages of the disease [16] .…”

Section: Introductionmentioning

confidence: 99%

Event‐related potentials during sustained attention and memory tasks: Utility as biomarkers for mild cognitive impairment

Waninger

Berka

Meghdadi

et al. 2018

Alz & Dem Diag Ass & Dis Mo

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Introduction The objective of the study is to validate attention and memory tasks that elicit event-related potentials (ERPs) for utility as sensitive biomarkers for early dementia. Methods A 3-choice vigilance task designed to evaluate sustained attention and standard image recognition memory task designed to evaluate attention, encoding, and image recognition memory were administered with concurrent electroencephalography acquisition to elicit ERPs in mild cognitive impairment (MCI) and healthy cohorts. ERPs were averaged, and mean or maximum amplitude of components was measured and compared between and within cohorts. Results There was significant suppression of the amplitude of the late positive potential in the MCI cohort compared with the healthy controls during 3-choice vigilance task, predominantly over occipital and right temporal-parietal region, and standard image recognition memory task over all regions. During standard image recognition memory task, diminished performance showed strong correlation with electroencephalography measurements. The old/new effects observed in the healthy controls cohort correlated with performance and were lost in MCI. Discussion ERPs obtained during cognitive tasks may provide a powerful tool for assessing MCI and have strong potential as sensitive and robust biomarkers for tracking disease progression and evaluating response to investigative therapeutics.

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Section: Introductionmentioning

confidence: 99%

Event‐related potentials during sustained attention and memory tasks: Utility as biomarkers for mild cognitive impairment

Waninger

Berka

Meghdadi

et al. 2018

Alz & Dem Diag Ass & Dis Mo

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show abstract

“…In language studies, the P600/LPC, also known as the 'Syntactic Positive Shift', has been linked to a wide range of disagreements in syntactic rules ( Kuperberg, 2007). P600 generators are median temporal lobe and paralimbic cortical regions (Katada et al, 2004;Kimiskidis and Papaliagkas, 2012).…”

Section: Delta Frequency Band (<4 Hz)mentioning

confidence: 99%

Treatment effects on event-related EEG potentials and oscillations in Alzheimer's disease

Yener

Hünerli-Gündüz

Yıldırım

et al. 2022

International Journal of Psychophysiology

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“…For stimulus locked averages only correct epochs were used, excluding trials with false alarms or misses. A digital low-pass filter was set at 17 Hz in order to reduce oversampling [13].…”

Section: Electrophysiological Recordingsmentioning

confidence: 99%

On the Comparison of a Novel Serious Game and Electroencephalography Biomarkers for Early Dementia Screening

Tarnanas

Laskaris

Tsolaki

et al. 2014

Advances in Experimental Medicine and Biology

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Patients with amnestic mild cognitive impairment are at high risk for developing Alzheimer's disease. Besides episodic memory dysfunction they show deficits in accessing contextual knowledge that further specifies a general spatial navigation task or an executive function (EF) virtual action planning. Virtual reality (VR) environments have already been successfully used in cognitive rehabilitation and show increased potential for use in neuropsychological evaluation allowing for greater ecological validity while being more engaging and user friendly. In our study we employed the in-house platform of virtual action planning museum (VAP-M) and a sample of 25 MCI and 25 controls, in order to investigate deficits in spatial navigation, prospective memory, and executive function. In addition, we used the morphology of late components in event-related potential (ERP) responses, as a marker for cognitive dysfunction. The related measurements were fed to a common classification scheme facilitating the direct comparison of both approaches. Our results indicate that both the VAP-M and ERP averages were able to differentiate between healthy elders and patients with amnestic mild cognitive impairment and agree with the findings of the virtual action planning supermarket (VAP-S). The sensitivity (specificity) was 100% (98%) for the VAP-M data and 87% (90%) for the ERP responses. Considering that ERPs have proven to advance the early detection and diagnosis of "presymptomatic AD," the suggested VAP-M platform appears as an appealing alternative.

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Event-related potentials for the diagnosis of mild cognitive impairment and Alzheimer's disease

Abstract: The reviewed evidence suggests that ERPs hold promise as an electrophysiological tool for the early and accurate diagnosis of AD and MCI. However, certain methodological issues need to be resolved before ERPs enter the arena of clinical practice.

Cited by 12 publications

References 89 publications

Event‐related potentials during sustained attention and memory tasks: Utility as biomarkers for mild cognitive impairment

Event‐related potentials during sustained attention and memory tasks: Utility as biomarkers for mild cognitive impairment

Treatment effects on event-related EEG potentials and oscillations in Alzheimer's disease

On the Comparison of a Novel Serious Game and Electroencephalography Biomarkers for Early Dementia Screening

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