Event‐related potentials to airway occlusion in young and old subjects

Harver, Andrew; Squires, Nancy K.; Bloch‐Salisbury, Elisabeth; Katkin, Edward S.

doi:10.1111/j.1469-8986.1995.tb03303.x

Cited by 54 publications

(63 citation statements)

References 35 publications

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“…Our results of the prolonged P3 latency and reduced P3 amplitude in the GAD group, compared to the healthy controls, are consistent with some notions given by the earlier RREP studies examining the effect of attention (Chan and Davenport, 2009;Harver et al, 1995;von Leupoldt et al, 2010bvon Leupoldt et al, , 2011aWebster and Colrain, 2000). In general, it has been suggested that P3 peak latency and amplitudes may be related to information processing speed and attentional resources allocation, respectively (Harver et al, 1995;Webster and Colrain, 2000).…”

Section: Discussionsupporting

confidence: 94%

“…In general, it has been suggested that P3 peak latency and amplitudes may be related to information processing speed and attentional resources allocation, respectively (Harver et al, 1995;Webster and Colrain, 2000). Specifically, Webster and Colrain (2000) found in their subject who presented a longer P3 latency during the counting RREP task also performed poorly in determining the duration of respiratory occlusions in the experiment.…”

Section: Discussionmentioning

confidence: 92%

“…Specifically, Webster and Colrain (2000) found in their subject who presented a longer P3 latency during the counting RREP task also performed poorly in determining the duration of respiratory occlusions in the experiment. Harver et al (1995) found that subjects presented both prolonged RREP P3 latency and reduced amplitudes when they ignored the occlusion stimulus by reading a magazine silently as compared to when they attended the occlusions by counting the occluded breaths. Importantly, our current finding of reduced RREP P3 amplitudes in patients with GAD parallels previous results in healthy subjects.…”

Section: Discussionmentioning

confidence: 97%

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Respiratory perception measured by cortical neural activations in individuals with generalized anxiety disorder

Chan

Leupoldt

Liu

et al. 2014

Respiratory Physiology & Neurobiology

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There has been evidence for the effect of anxiety on the neural processing of respiratory sensation using the respiratory-related evoked potentials (RREP) elicited by inspiratory occlusions. This study tested the RREP elicited by inspiratory occlusions in a group of outpatients with generalized anxiety disorder (GAD) and a group of healthy controls. We hypothesized that the RREP P3 peak would be modulated in the GAD patients. A RREP oddball paradigm of 150-ms inspiratory occlusion protocol was used in 15 GAD patients and 11 healthy adults with normal lung functions. The RREP was recorded with a 40-channel electroencephalography (EEG) system. A minimum of 100 occlusions was collected for data analysis. We found that the averaged P3 latency of the GAD patients was significantly longer than the P3 latency of the healthy controls. In addition, the GAD group showed significantly reduced P3 amplitudes compared to the control group. No group differences in latency and amplitudes were found for earlier RREP components. These results demonstrated that a delayed and reduced attention peak (P3) is present in patients with GAD. This suggests that GAD as a disease state modulates the higher order processing of respiratory perception.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 97%

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Respiratory perception measured by cortical neural activations in individuals with generalized anxiety disorder

Chan

Leupoldt

Liu

et al. 2014

Respiratory Physiology & Neurobiology

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“…Controlled attention occurs when an added inspiratory load is applied to a subject actively attending to their breathing (load attend state). Significant differences between ignore and attend states have been reported for load-elicited brain activities, i.e., RREP N1 and P300 peak amplitudes were greater in the attend trials (Harver et al, 1995;Webster and Colrain, 2000). This suggests gating of automatic attention with load detection and gating-related modulation of controlled attention.…”

mentioning

confidence: 80%

Respiratory-Related-Evoked Potential Measures of Respiratory Sensory Gating in Attend and Ignore Conditions

Chan

Davenport

2009

Journal of Clinical Neurophysiology

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Respiratory sensory gating is evidenced by decreased respiratory-related-evoked potentials (RREP) amplitude of the N1 peak for the second stimulus (S2) when two occlusions are separated by a 500-millisecond interval. The RREP N1 peak amplitude ratio of the S2 and the first occlusion (S1), S2/S1, is usually <0.5. Controlled attention of respiratory loads is measured by the P300 peak of the RREP. We hypothesized that the paired occlusion elicited N1 and the P300 peak amplitudes will be modulated by controlled attention. The RREP was recorded in ignore and attend trials. The amplitudes of the RREP Nf, P1, N1, and P300 peaks for S1 and S2 and the S2/S1 ratios were measured for both trials. The S1 amplitudes of the Nf, P1, and N1 peaks were not significantly different between the attend and ignore conditions. The S2 Nf, P1, and N1 peak amplitudes were not significantly different between conditions but were all significantly less than S1. The S2/S1 ratios for Nf, P1, and N1 peaks were not significantly different between the attend and ignore conditions. The S1 RREP P300 peak amplitude in attend trials was significantly greater than in ignore trails. The attend S1 P300 amplitude was significantly greater than the attend S2 amplitude. The attend P300 S2/S1 ratio was significantly less than the ignore ratio. These results demonstrated that respiratory gating is evident in both attend and ignore conditions. The P300 peak S2/S1 ratio is consistent with controlled attention modulation of central neural gating of respiratory mechanosensation.

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“…We are aware of only one study which has tested age differences in respiratory-related evoked potentials (RREP, Harver et al, 1995). This study found reduced amplitude of RREPs in older compared to younger age and these age differences were more pronounced in later cognition-related components of RREPs.…”

Section: Central Pathways Between Age and Dyspneamentioning

confidence: 97%