Evidence-based guidelines for physiotherapy management of patients with multiple myeloma: study protocol

Abstract

BackgroundPatients with multiple myeloma (MM) are often treated with chemotherapy, radiation, and, if indicated, autologous stem cell transplant. In addition to side effects of the treatment, patients with MM often have bone pain, pathological fractures, spinal cord compressions, fatigue, and muscle weakness, which negatively impact functional performance and quality of life. Currently, there are no related guidelines for safe and effective physiotherapy (PT) management. Accordingly, the aim of the present study is to develop guidelines for effective physiotherapy management of patients with MM by systematically reviewing and evaluating the available evidence followed by a consensus process to specifically describe the research questions as detailed below.Methods/designPhysiotherapy management guidelines for patients with multiple myeloma will be developed based on the results of a systematic search of the following databases: US National Library of Medicine Database (PubMed), Medical Literature Analysis and Retrieval System Online (MEDLINE), Excerpta Medica Database (EMBASE), Cumulative Index to Nursing and Allied Health Literature (CINAHL), Elton B. Stephens Co. (EBSCO), Web of Science, Database of Abstracts of Reviews of Effects (DARE), Cochrane Database of Systematic Review, and Physiotherapy Evidence Database (PEDro). All articles will be screened for inclusion and exclusion criteria. Relevant potential articles will be identified and systematically reviewed for final phase of inclusion. Two independent reviewers will systematically review and analyze the quality of identified articles using standardized assessment tools. Scientific conclusions will be drawn and recommendations will be made based on a critical appraisal process. The guideline development will also be based on the team’s judgment about the overall quality of the studies and a consensus process.DiscussionDraft guidelines will be developed in the form of action statements based on the strength of evidence and grades of recommendations. The draft guidelines will be reviewed internally by two independent reviewers using AGREE II and externally by a methodological expert from Evidence-Based Care – Cancer Care Ontario and will be sent to the Canadian Physiotherapy Association (CPA) for feedback from physiotherapists.Systematic review registrationPROSPERO CRD42017064056Electronic supplementary materialThe online version of this article (10.1186/s13643-018-0785-7) contains supplementary material, which is available to authorized users.

In-hospital rehabilitation in the treatment of multiple myeloma

“…In the available literature, no specific guidelines regarding a safe and effective rehabilitation process in the course of MM treatment have been found. Treatment plans and decisions on therapeutic management should be based on individual clinical circumstances [19].…”

Mobilization and Exercise Intervention for Patients With Multiple Myeloma: Clinical Practice Guidelines Endorsed by the Canadian Physiotherapy Association

“…), as outlined in the study protocol, to understand the research evidence around the physical therapy management of MM. 7 In brief, a reviewer (Z.M.) systematically searched databases and retrieved 48,060 articles with EndNote software, and 28,679 articles were recovered after removing duplicates.…”

“…using the standardized methodological assessment tool outlined in the study protocol. 7 Supplementary Table 1 shows the study characteristics and the critical appraisal scores of each included article.…”

“…Recommendations were made in the form of AS, along with levels of evidence and grades, as outlined in the study protocol. 7 An a priori threshold of 80% agreement was used to establish a consensus for each AS, and a quality cut score of greater than 70% was set for AGREE II domains for consideration of the guidelines. 8 …”