Evidence‐based practice standards for the use of topical pressurised oxygen therapy

Orsted, Heather L.; Poulson, Randy; Baum, Joseph J.; Christensen, Dawn; Despatis, Marc; Goettl, Kyle; Haligowski, David; Ho, Chester; Keith, L; O'Sullivan-Drombolis, Deirdre K.; Winberg, Valerie; Woo, Kevin

doi:10.1111/j.1742-481x.2012.00956.x

Cited by 17 publications

(23 citation statements)

References 8 publications

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“…71 The lack of a formal study in this regard has been offset by several reviews, case series, and experimental studies on the effect of topically administered oxygen at the wound surface that seem to indicate a benefit in promoting wound repair. 154,[159][160][161][162][163][164][165][166][167][168][169] While several RCTs with different devices have been ongoing, there have been no publications to date comparing 12-week healing rates with those of standard care.…”

Section: Negative Pressure Wound Therapymentioning

confidence: 99%

Challenges in the Treatment of Chronic Wounds

Frykberg

Banks

2015

Advances in Wound Care

1,816

1,429

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Significance: Chronic wounds include, but are not limited, to diabetic foot ulcers, venous leg ulcers, and pressure ulcers. They are a challenge to wound care professionals and consume a great deal of healthcare resources around the globe. This review discusses the pathophysiology of complex chronic wounds and the means and modalities currently available to achieve healing in such patients.Recent Advances: Although often difficult to treat, an understanding of the underlying pathophysiology and specific attention toward managing these perturbations can often lead to successful healing.Critical Issues: Overcoming the factors that contribute to delayed healing are key components of a comprehensive approach to wound care and present the primary challenges to the treatment of chronic wounds. When wounds fail to achieve sufficient healing after 4 weeks of standard care, reassessment of underlying pathology and consideration of the need for advanced therapeutic agents should be undertaken. However, selection of an appropriate therapy is often not evidence based.Future Directions: Basic tenets of care need to be routinely followed, and a systematic evaluation of patients and their wounds will also facilitate appropriate care. Underlying pathologies, which result in the failure of these wounds to heal, differ among various types of chronic wounds. A better understanding of the differences between various types of chronic wounds at the molecular and cellular levels should improve our treatment approaches, leading to better healing rates, and facilitate the development of new more effective therapies. More evidence for the efficacy of current and future advanced wound therapies is required for their appropriate use.

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Section: Negative Pressure Wound Therapymentioning

confidence: 99%

Challenges in the Treatment of Chronic Wounds

Frykberg

Banks

2015

Advances in Wound Care

1,816

1,429

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“…For example, the use of oxygen under pressure or "hyperbaric oxygen therapy" (HBO 2 ) was shown to have a positive effect on ischemia and local wound hypoxia (4)(5)(6). In the last few years, additional medical procedures that allow topical administration of oxygen therapy directly to the wound site in order to support wound healing have been developed (7)(8)(9). One of the major complications affecting wound healing are infection, many of which are caused by multidrug-resistant pathogens and surface-associated (biofilm) bacteria (1,(10)(11)(12).…”

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confidence: 99%

Measurement of Predation and Biofilm Formation under Different Ambient Oxygen Conditions Using a Simple Gasbag-Based System

Kadouri

Tran

2013

Appl Environ Microbiol

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Bdellovibrio bacteriovorus and Micavibrio aeruginosavorus are Gram-negative bacteria characterized by predatory behavior. The aim of this study was to evaluate the ability of the predators to prey in different oxygen environments. When placed on an orbital shaker, a positive association between the rate of aeration and predation was observed. To further examine the effects of elevated ambient oxygen levels on predation, a simple gasbag system was developed. Using the system, we were able to conduct experiments at ambient oxygen levels of 3% to 86%. When placed in gasbags and inflated with air, 50% O 2 , and 100% O 2 , positive predation was seen on both planktonic and biofilm-grown prey cells. However, in low-oxygen environments, predatory bacteria were able to attack only prey cells grown as biofilms. To further evaluate the gasbag system, biofilm development of Grampositive and Gram-negative microorganisms was also measured. Although the gasbag system was found to be suitable for culturing bacteria that require a low-oxygen environment, it was not capable of supporting, with its current configuration, the growth of obligate anaerobes in liquid or agar medium.A cute and chronic wounds are a major burden to public health and the economy (1). It is estimated that, in the United States alone, chronic wounds affect 6.5 million patients (2). One medical procedure used to promote wound healing is the use of oxygen therapy (3). For example, the use of oxygen under pressure or "hyperbaric oxygen therapy" (HBO 2 ) was shown to have a positive effect on ischemia and local wound hypoxia (4-6). In the last few years, additional medical procedures that allow topical administration of oxygen therapy directly to the wound site in order to support wound healing have been developed (7-9). One of the major complications affecting wound healing are infection, many of which are caused by multidrug-resistant pathogens and surface-associated (biofilm) bacteria (1, 10-12). It was previously suggested that predatory bacteria from the genus Bdellovibrio and Micavibrio could be used as live antibiotics to control wound infections (13,14).The purpose of this study was to evaluate the ability of predatory bacteria to prey in elevated ambient O 2 levels with the longterm goal of using predatory bacteria in combination with traditional oxygen therapy in order to enhance wound healing. To this end, a new gasbag system that allowed experiments to be conducted in diverse gas environments was developed. The system was also used to evaluate biofilm formation of medically relevant Gram-positive and Gram-negative bacteria in O 2 environments that were not examined previously. MATERIALS AND METHODSPredatory bacteria. The predatory bacteria used in this study were Micavibrio aeruginosavorus ARL-13 (15, 16), Bdellovibrio bacteriovorus 109J (ATCC 43826), B. bacteriovorus HD100 (17, 18), and a previously isolated host-independent (HI) variant of B. bacteriovorus 109J (19). The HI variant was cultured at 30°C in peptone-yeast extract (PYE) (10 g/liter p...

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“…2 In 2005 the Undersea and Hyperbaric Medicine Society (UHMS) published a position statement regarding TOT use in chronic wounds and concluded that ''topical oxygen as a therapeutic strategy in wound healing is not adequately supported by scientific data.'' 3 A number of studies have been published so far.…”

Section: Introductionmentioning

confidence: 99%

Topical Oxygen for Chronic Wounds: A PRO/CON Debate

Mutluoğlu

Cakkalkurt

Uzun³

et al. 2013

Journal of the American College of Clinical Wound Specialists

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The role of oxygen in wound healing is universally accepted and does not require any further evidence; however the controversy as to whether oxygen delivery systems have the potential to improve wound healing remains to be concluded. Topical oxygen treatment (TOT) involves the delivery of 100% oxygen for a mean of 90 min, once a day at an atmospheric pressure slightly above 1 atm abs. The use of TOT gained increasing interest recently. The current manuscript will summarize the pros and cons of TOT in the view of the available literature.

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Evidence‐based practice standards for the use of topical pressurised oxygen therapy

Cited by 17 publications

References 8 publications

Challenges in the Treatment of Chronic Wounds

Challenges in the Treatment of Chronic Wounds

Measurement of Predation and Biofilm Formation under Different Ambient Oxygen Conditions Using a Simple Gasbag-Based System

Topical Oxygen for Chronic Wounds: A PRO/CON Debate

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