Evidence-Based Support for Nutrition Therapy in Head and Neck Cancer

Nesemeier, Ryan; McClave, Stephen A.; Tennant, Paul

doi:10.1007/s40137-017-0179-0

Cited by 20 publications

(28 citation statements)

References 107 publications

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“…Nutrition is crucial in all stages of the antineoplastic treatment 27 and the treatment may be conditional on the limitations arising from injuries in the oral mucositis cavity. 6,28 These factors can affect the patient's health status in reason of difficult to nutrition before the diagnosis inherent to cancer in development. 29…”

Section: Discussionmentioning

confidence: 99%

Chemotherapy in Pediatric Oncology Patients and the Occurrence of Oral Mucositis

Ribeiro

Neto

Valença

2019

International Journal of Clinical Pediatric Dentistry

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BackgroundIt is known that chemotherapeutic agents are not equally stomatotoxic and oral cavity lesions are the most frequent complications encountered in antineoplastic chemotherapy.AimsThe objective of this study was to evaluate the occurrence of severe oral mucositis during a chemotherapy treatment and to identify its relationship with the chemotherapeutic class used.Materials and methodsThis is a longitudinal, prospective, and observational study that used an intensive direct observation technique for assessing the oral clinical conditions and the chemotherapy treatment administered to 105 patients (both children and adolescents).ResultsSevere oral mucositis occurred in all the 10 weeks of evaluation (ranging from 16.2 to 31.4%) and the association between the type of chemotherapy and the occurrence of severe oral mucositis is recorded only in the 6th week, with the chance to develop severe oral mucositis being 3.07 (3.85–2.29) times higher in patients underwent chemotherapy with antimetabolites than in those who have not used chemotherapy (p = 0.012).ConclusionIt was concluded that the chemotherapeutic agents most related to severe oral mucositis and to the interruption in chemotherapy are those of the class of antimetabolites, especially the methotrexate and the Ara C.How to cite this articleRibeiro ILA, de Andrade Lima Neto E, et al. Chemotherapy in Pediatric Oncology Patients and the Occurrence of Oral Mucositis. Int J Clin Pediatr Dent 2019;12(4):261–267.

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Section: Discussionmentioning

confidence: 99%

Chemotherapy in Pediatric Oncology Patients and the Occurrence of Oral Mucositis

Ribeiro

Neto

Valença

2019

International Journal of Clinical Pediatric Dentistry

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“…11,111,112 Further, cancers of the head and neck receiving surgery and chemoradiation often require enteral or parenteral nutrition to overcome challenges to eating and consuming food. 113 Malabsorption is also a common concern in certain tumour types (e.g. gastro-oesophageal and pancreatic) where tumour location and different treatments may result in a reduced ability to absorb nutrients.…”

Section: Malnutritionmentioning

confidence: 99%

Muscle wasting in cancer: opportunities and challenges for exercise in clinical cancer trials

Fairman

Lønbro

Cardaci

et al. 2021

JCSM Rapid Communications

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Background Low muscle in cancer is associated with an increase in treatment-related toxicities and is a predictor of cancer-related and all-cause mortality. The mechanisms of cancer-related muscle loss are multifactorial, including anorexia, hypogonadism, anaemia, inflammation, malnutrition, and aberrations in skeletal muscle protein turnover and metabolism. Methods In this narrative review, we summarise relevant literature to (i) review the factors influencing skeletal muscle mass regulation, (ii) provide an overview of how cancer/treatments negatively impact these, (iii) review factors beyond muscle signalling that can impact the ability to participate in and respond to an exercise intervention to counteract muscle loss in cancer, and (iv) provide perspectives on critical areas of future research. Results Despite the well-known benefits of exercise, there remains a paucity of clinical evidence supporting the impact of exercise in cancer-related muscle loss. There are numerous challenges to reversing muscle loss with exercise in clinical cancer settings, ranging from the impact of cancer/treatments on the molecular regulation of muscle mass, to clinical challenges in responsiveness to an exercise intervention. For example, tumour-related/treatmentrelated factors (e.g. nausea, pain, anaemia, and neutropenia), presence of comorbidities (e.g. diabetes, arthritis, and chronic obstructive pulmonary disease), injuries, disease progression and bone metastases, concomitant medications (e.g., metformin), can negatively affect an individual's ability to exercise safely and limit subsequent adaptation. Conclusions This review identifies numerous gaps and oppportunities in the area of low muscle and muscle loss in cancer. Collaborative efforts between preclinical and clinical researchers are imperative to both understanding the mechanisms of atrophy, and develop appropriate therapeutic interventions.

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“…These findings are probably due to the exacerbation of the obliterative endarteritis and fibrosis induced by the (chemo) radiation itself in local tissues [ 16 ]. While malnutrition should be aggressively corrected during the whole perioperative period [ 17 ], in the setting of a salvage laryngectomy/pharyngolaryngectomy the prophylactic use of a reinforcing flap has been shown to significantly decrease PCF risk [ 18 ]. In addition, while early oral feeding seems to increase PCF risk according to a recent meta-analysis [ 19 ], early oral hydration may actually reduce this probability (by a possible mechanical detersion of infected fluids and saliva on pharyngeal suture) [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

Non-Surgical Strategies for Assisting Closure of Pharyngocutaneous Fistula after Total Laryngectomy: A Systematic Review of the Literature

Locatello

Licci

Maggiore

et al. 2021

JCM

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Background: Pharyngocutaneous fistula (PCF) is a frequent complication after total laryngectomy, with an incidence of up to 65%. Many conservative or invasive approaches are available and the choice among them is usually made on a case-by-case basis. The aim of the present review is to critically summarize the available evidence of the effectiveness of the non-surgical management of PCF. Methods: A systematic review and a meta-analysis of the literature were conducted, according to the PRISMA guidelines. Studies investigating botulinum toxin therapy, scopolamine transdermal patch, hyperbaric oxygen therapy (HBOT), and negative pressure wound therapy (NPWT) were assessed. Complete fistula closure after the initiation of non-surgical treatment was the main outcome. Results: After the application of selection criteria, a total of seven articles and 27 patients were included in the present review. All the eligible studies were descriptive case series, while only one article used a standard group as a comparison. The mean age was 63.3 and 14 patients (51.9%) had previously received RT. The reported comorbidities were diabetes, ischemic heart disease, hypertension, dyslipidemia, COPD, and atrial fibrillation. With a mean healing time of 25.0 days, the overall success rate was 92.6%. Conclusions: Non-surgical treatment of PCF is only based on the experience of small series. Although success rates seem promising, the absence of properly designed comparative studies does not allow us, at present, to identify ideal candidates for these non-invasive management strategies for PCF.

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Evidence-Based Support for Nutrition Therapy in Head and Neck Cancer

Cited by 20 publications

References 107 publications

Chemotherapy in Pediatric Oncology Patients and the Occurrence of Oral Mucositis

Chemotherapy in Pediatric Oncology Patients and the Occurrence of Oral Mucositis

Muscle wasting in cancer: opportunities and challenges for exercise in clinical cancer trials

Non-Surgical Strategies for Assisting Closure of Pharyngocutaneous Fistula after Total Laryngectomy: A Systematic Review of the Literature

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