Evidence-Based Treatment of Chronic Leg Ulcers

Kahle, Birgit; Hermanns, Hans-Joachim; Gallenkemper, G.

doi:10.3238/arztebl.2011.0231

Cited by 65 publications

(74 citation statements)

References 25 publications

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“…Chronic wounds due to wound healing disturbances are characterized by loss of integrity of the skin and, in some cases, of underlying anatomical structures, as well as a lack of recovery within a period of at least eight weeks [ 3 ] . By defi nition, chronic wounds are progressive and resistant to multiple treatments, either because of failure to conduct a thorough diagnostic workup or due to the lack of causal treatment options.…”

Section: Epidemiology Of Chronic Woundsmentioning

confidence: 99%

Pathogenesis of wound healing disorders in the elderly

Makrantonaki

Wlaschek

Scharffetter‐Kochanek

2017

J Deutsche Derma Gesell

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Summary The elderly constitute the age group most susceptible to wound healing disorders and chronic wounds, the most prevalent being venous leg ulcers, pressure ulcers, and diabetic foot ulcers. However, other age‐associated diseases should also be taken into consideration in the diagnostic workup of chronic wounds, and not be underestimated. A better understanding of the pathomechanisms involved in the wound healing process is of key importance in combatting the difficulties associated with the treatment of chronic wounds. In recent decades, considerable progress has been made in the development of pioneering therapeutic strategies for chronic wounds. In this context, the use of growth factors and cytokines, tissue engineering, and cell therapy – including stem cells – have proven very promising. Nevertheless, prior to their introduction into routine clinical practice, large controlled clinical trials are required to assess the safety of these techniques.

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Section: Epidemiology Of Chronic Woundsmentioning

confidence: 99%

Pathogenesis of wound healing disorders in the elderly

Makrantonaki

Wlaschek

Scharffetter‐Kochanek

2017

J Deutsche Derma Gesell

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“…Guidelines and reviews for wound treatments [6][7][8][9][10] suggest that in any case dressing should be cost effective. Cost-effectiveness must be taken into maximal consideration; the risk could be that patients or nurses preferences push into using dressings slightly more effective but much more expensive.…”

Section: Questions and Answersmentioning

confidence: 99%

“…A sufficient compression pressure seems to be used by the majority according to some consensus and meta-analysis, [1][2][3][4][5][6][7][8][9][10]16,20 however pressure value is mostly theoretical as is very rarely measured. 4 Furthermore, while compression stockings have a pressure declared by manufacturing company (which correspond to an approximate value on the leg), the pressure of the bandages can be extremely variable only depending on the stretch applied to the bandage itself.…”

Section: Questions and Answersmentioning

confidence: 99%

Hot topics in venous ulcer treatment: an international survey

Ricci

Serino

Moro

et al. 2012

Veins and Lymphatics

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“…1 Ulcers can be defined as wounds with a "full thickness depth" and a "slow healing tendency". 2 A correct diagnosis is essential to avoid inappropriate treatment that may delay wound healing, cause deterioration of the wound, or harm the patient.…”

Section: Introductionmentioning

confidence: 99%

A comparative study between aloe vera gel dressing and conventional dressing in chronic wounds

et al. 2017

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Background: The aim of this study was to evaluate the effectiveness and rate of healing of Aloe vera gel in treatment of chronic wounds, to compare the effectiveness of Aloe vera gel with conventional dressing (normal saline and povidone iodine) and to assess the percentage reduction of wound healing with Aloe vera gel dressing.Methods: The study was conducted at Dr. D. Y. Patil Medical College and Hospital, DPU University, for a period of 2 months (from January 2017 to March 2017) and is a prospective and comparative randomized type of study using 50 cases (Group A and Group B, 25 each). The study was approved by the Institute’s Ethics Committee.Results: Data analysis showed that at the end of 4 weeks, mean surface area in Group A is reduced to 4.58 cm2 from 9.79 cm2 which is higher than that in the control group. Also, the average rate of healing in Aloe vera gel is more than control group. Percentage reduction in ulcer surface area was calculated to be much more in Group A as compared to Group B.Conclusions: The study concluded that Aloe vera gel is highly effective in treatment of chronic ulcers and stimulates the growth of wound healing. Thus, reducing the hospital stay. Apart from being efficacious in wound healing, Aloe vera gel is safe product. No allergic reactions/infections were associated with Aloe vera gel. Aloe vera gel not only heals faster but is also cost effective.

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Evidence-Based Treatment of Chronic Leg Ulcers

Cited by 65 publications

References 25 publications

Pathogenesis of wound healing disorders in the elderly

Pathogenesis of wound healing disorders in the elderly

Hot topics in venous ulcer treatment: an international survey

A comparative study between aloe vera gel dressing and conventional dressing in chronic wounds

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