Evidence-based update on rosacea comorbidities and their common physiologic pathways

Holmes, Anna; Spoendlin, Julia; Chien, Anna L.; Baldwin, Hilary; Chang, Anne Lynn S.

doi:10.1016/j.jaad.2017.07.055

Cited by 99 publications

(115 citation statements)

References 116 publications

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“…Hitherto conducted studies confirm a significant bi‐directional association in the occurrence of IBD and rosacea . Other examples of concomitant gastrointestinal conditions are coeliac disease, gastrointestinal flora alterations and metabolic conditions such as obesity and insulin resistance . Nam et al .…”

Section: Methodsmentioning

confidence: 94%

The gut microbiome alterations in allergic and inflammatory skin diseases – an update

Polkowska-Pruszyńska

Gerkowicz

Krasowska

2019

Acad Dermatol Venereol

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The human microbiome is a wide range of microorganisms residing in and on our body. The homeostasis between host immune system and the microbial environment allows mutual benefits and protection. Physiological bacterial colonization is essential for the establishment of organism immunity. The human microbiota ecosystem can be divided into several compartments, out of which intestinal flora strongly affects our health and plays a crucial role in the pathophysiology of many diseases. The gastrointestinal tract, being a major guardian of the immune system, maintains the homeostasis with the commensal microorganisms by tolerating the typical flora antigens. The dysbiosis may trigger an inflammatory response followed by tissue damage or autoimmune processes. The gut microbiome alterations are linked to the pathogenesis of the allergic, cardiovascular, gastrointestinal, metabolic, neurodevelopmental, psychiatric and neurodegenerative diseases and cancer. Moreover, there is increasing evidence connecting the skin condition with the gastrointestinal microbiome, which has been described as the skin–gut axis. The aim of this study was to review the literature regarding the role of the gut microbiome alterations in the pathogenesis of selected allergic and inflammatory skin diseases.

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Section: Methodsmentioning

confidence: 94%

The gut microbiome alterations in allergic and inflammatory skin diseases – an update

Polkowska-Pruszyńska

Gerkowicz

Krasowska

2019

Acad Dermatol Venereol

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“…Rosacea is significantly associated with allergies, respiratory and gastrointestinal tract disorders, metabolic and cardiovascular diseases, major depression, Parkinson's disease, and some cancers . Very recently, an evidence‐based update on rosacea comorbidities and their physiologic pathways were reviewed . The present study aimed to determine what systemic comorbidities accompany rosacea (primary objective) and to determine the relationship between the subtype, severity, and duration of rosacea and the presence of and type of systemic comorbidities (secondary objective).…”

Section: Introductionmentioning

confidence: 99%

Systemic comorbidities associated with rosacea: a multicentric retrospective observational study

et al. 2018

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Background Once considered a disorder limited to the skin, rosacea is now known to be associated with systemic disorders. The aim of this study was to determine what systemic comorbidities accompany rosacea and to determine the relationship between the type, severity, and duration of rosacea, and the presence of and type of systemic comorbidities. Methods This retrospective multicenter study was conducted by the Turkish Society of Dermatology Acne Study Group. Thirteen dermatology clinics throughout Turkey participated in the study. A structured physician‐administered questionnaire was used to collect patient demographics, clinical findings, and lifestyle data. The principal rosacea subtype, physician global assessment of severity, and duration of rosacea were recorded. Physicians recorded each participant's medical history, including current and past comorbidities, duration of any such comorbidity, and the use of medications to treat any comorbidities. Results The study included 1,195 rosacea patients and 621 controls without rosacea aged 18–85 years. As compared to the controls, more of the rosacea patients had respiratory tract, gastrointestinal system, and metabolic and hepatobiliary system disorders in a rosacea's severity‐ and duration‐dependent manner. Conclusion Clinicians must be aware of the potential for systemic comorbidities in rosacea patients, which becomes more likely as disease duration and severity increase.

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“…Environmental factors including temperature changes, spicy food, exercise, stress and disorder of skin microbes may lead to the activation of pattern recognition receptors, which subsequently contribute to the occurrence of rosacea. 8,9 Based on the potential correlations of these risk factors with rosacea, we investigated the possible involvement of dietary factors in the occurrence and severity of rosacea. 6,7 In addition, several studies suggested a potential relationship between Helicobacter pylori infection, small intestinal bacterial overgrowth (SIBO) and rosacea.…”

Section: Introductionmentioning

confidence: 99%

Relationship between rosacea and dietary factors: A multicenter retrospective case–control survey

Yuan

Huang

Wang

et al. 2019

The Journal of Dermatology

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Although patients with rosacea often consult dermatologists for dietary factors that might be related to their skin disorders, few studies have been conducted to research the relationship between rosacea and dietary factors. The purpose of this study was to evaluate the potential relationship between rosacea and diet among the large Chinese population with rosacea, which would provide dietary guidelines for patients with rosacea. A multicenter case–control study was conducted. The feeding frequency 2 years before the occurrence of rosacea was collected by standardized questionnaires. Multiple logistic regression analysis was used to calculate risks related to the diet. One thousand three hundred and forty‐seven patients with rosacea and 1290 controls were enrolled in our study. We found that high‐frequency intake of fatty food and tea presented a positive correlation with rosacea, while high‐frequency dairy product intake showed significant negative correlation with rosacea. Sweet food, coffee and spicy food appeared to be independent of any subset of rosacea in our study. However, high‐frequency dairy product intake showed a borderline beneficial effect on rosacea severity. We further analyzed the correlation between diet and the subtype of rosacea. We found that high‐frequency fatty intake was associated with erythematotelangiectatic rosacea (ETR) and phymatous rosacea, while high‐frequency tea intake was only associated with ETR. In addition, high‐frequency dairy product intake showed negative correlations with ETR and papulopustular rosacea. Rosacea is associated with some dietary factors, and our study is valuable in establishing dietary guidelines to prevent and improve rosacea.

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Evidence-based update on rosacea comorbidities and their common physiologic pathways

Cited by 99 publications

References 116 publications

The gut microbiome alterations in allergic and inflammatory skin diseases – an update

The gut microbiome alterations in allergic and inflammatory skin diseases – an update

Systemic comorbidities associated with rosacea: a multicentric retrospective observational study

Relationship between rosacea and dietary factors: A multicenter retrospective case–control survey

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