Evidence for a causal relationship between immune cells and cutaneous melanoma: a Mendelian randomization study

Abstract

Evidence for a causal relationship between immune cells and cutaneous melanoma: a Mendelian randomization study Dear Editor, Cutaneous melanoma is one of the most immunogenic malignancies due to its incredibly high genomic mutational load and potential for favorable immune response. 1 To date, metastatic melanoma cases treated with the cytotoxic T lymphocyte-associated protein 4 (CTLA-4) antibody ipilimumab showed that 20% of patients were alive at 3 years. 1 The most crucial challenge GWAS data can be obtained from the MRC IEU Open GWAS database (https://gwas.mrcieu.ac.uk/).