Evidence for a Gm
ab Allele in the Gm System of American Negroes

Steinberg, Arthur G.; Stauffer, Rachel; Boyer, Samuel H.

doi:10.1038/188169a0

Cited by 42 publications

(18 citation statements)

References 4 publications

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“…Thus it would appear that the almost invariable existence of the Gm(a+b+) phenotype in the Negro can be readily explained on the basis of a form of inheritance similar to that in Caucasians and does not require a Gmab allele [18,17] unique to the Negro race.…”

Section: Discussionmentioning

confidence: 99%

“…Similar data on Negro myeloma proteins would be helpful in evaluating the hypothesis that a Gmab allele exists in the Negro. However, the scanty data on American Negroes with myeloma are not conclusive because of the high incidence of Caucasian genes in the American Negro [18]. The subsequent delineation of a new hereditary y-globulin factor, Gm(f) [8], present in almost all Gm(b+) Caucasians but invariably absent in Negroes, aids in accurate classification of subjects as Negro or Caucasian insofar as y-globulin genes are concerned.…”

mentioning

confidence: 99%

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Molecular Localization of Gm(a) and Gm(b) Factors in Negroes*

Fudenberg¹,

Feinstein²,

McGehee³

et al. 1966

Vox Sanguinis

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Molecular Localization of Gm(a) and Gm(b) Factors in Negroes*

Fudenberg¹,

Feinstein²,

McGehee³

et al. 1966

Vox Sanguinis

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“…Harboe et al (6) found all d 6 myeloma globulins from Negroes to be Gm (a+b--) and not Gm(a+b+) as might have been suspected from the current hypothesis that all Negroes are homozygous for a gene Gm "b (24). This finding was suggestive evidence, first, that Gm• and Gmb are indeed distinct, though closely linked genes in Negroes and, second, that Gm• in Negroes, like in Whites, expresses its information in a much larger proportion of the ~,~-globulin molecules than Gmb.…”

Section: Anti-rh Antibodies and Their Properties As Components In The Gmmentioning

confidence: 99%

“…It is well established that genes Gm ~ and Gm b cannot be alleles in Negroes, as practically all Negroes are Gm(a-bb-b) (24). Of 10 American Negro sera available 7 were found to be Gm(a÷bq-f-), a very rare type in Caucasians, and 3 were Gm (a4-b-bf-b).…”

Section: Anti-rh Antibodies and Their Properties As Components In The Gmmentioning

confidence: 99%

ON THE RELATIONSHIPS BETWEEN THE γ-GLOBULIN GENES OF THE GM SYSTEM

Mårtensson

1964

The Journal of Experimental Medicine

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Gm types of sera from Caucasians and Negroes, of myeloma globulins, and of specific antibodies were investigated. In particular the relationship between the recently identified gene Gmf and other Gm genes was analyzed. 1. Caucasians were, with rare exceptions, either Gm(b+f+) or Gm(b-f-). 2. In Negroes, on the other band, type Gm(b+f-) was found to be common. 3. No myeloma globulins appeared to contain the product of more than 1 of the 3 genes Gma, Gmb, and Gmf, even though the large majority of normal individuals, as well as myeloma patients, possess 2 or all 3 of these genes. 4. The types Gm(a+b-f-) and Gm(a-b-f+) represented the 2 major groups among the γ2-myeloma globulins; each comprised roughly 40 per cent. The types Gm(a- b+f-) and Gm(a-b-f-) are minor groups. 5. All Gm(x+) myeloma globulins were also Gm(a+). Approximately half of the Gm(a+) myeloma globulins were Gm(x+). 6. In the majority, but not in all, of Gm(a+) sera the anti-Rh antibodies were clearly Gm(a+). Similarly, the anti-Rh antibodies of Gm(f+) sera were most often, but not always, also Gm(f+). In contrast, only a minor proportion of Gm(b+) anti-Rh sera sensitized red cells to anti-Gm(b).

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“…As all Negroes are of the phenotype Gm(a+b+x-), Steinberg [27] has put forward the theory that most of them have a gene Gmab, the alleles Gm3-and Gmb when they occur being due to admixture of other races. He also supposes that Indians and Eskimos have three allelic genes, Gm3-, Gm3-*, and Gmab [29].…”

Section: Ropartz Et Almentioning

confidence: 99%

Serum Groups Defined by Agglutination Inhibition Tests : Gm Groups and Inv Groups

Ropartz¹

1962

Vox Sanguinis

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Evidence for a Gm ab Allele in the Gm System of American Negroes

Cited by 42 publications

References 4 publications

Molecular Localization of Gm(a) and Gm(b) Factors in Negroes*

Molecular Localization of Gm(a) and Gm(b) Factors in Negroes*

ON THE RELATIONSHIPS BETWEEN THE γ-GLOBULIN GENES OF THE GM SYSTEM

Serum Groups Defined by Agglutination Inhibition Tests : Gm Groups and Inv Groups

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