Evidence for a link between tail biting and central monoamine metabolism in pigs (Sus scrofa domestica)

Valros, Anna; Palander, Pälvi; Heinonen, Mari; Munsterhjelm, Camilla; Brunberg, Emma; Keeling, Linda J.; Piepponen, Petteri

doi:10.1016/j.physbeh.2015.02.049

Cited by 43 publications

(29 citation statements)

References 39 publications

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“…The lesion of rear part generally included the hind legs until the tail (Rundgren and Löfquist, 1989;Melotti et al, 2011). In addition, it is known that tail biting in piglets is a serious animal welfare problem with causing wounds, amputation of the tail and infections, which would cause a growth reduction (Heinonen et al, 2010;Valros et al, 2015). So to lessen tail biting, all piglets were processed following standard commercial practices of tail docking.…”

Section: Discussionmentioning

confidence: 99%

The effect of mixing levels on aggression at weaning in piglets

Mei

Yang

Luo

et al. 2016

Applied Animal Behaviour Science

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Section: Discussionmentioning

confidence: 99%

The effect of mixing levels on aggression at weaning in piglets

Mei

Yang

Luo

et al. 2016

Applied Animal Behaviour Science

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“…Immobilization of pigs produces changes in hypothalamic and/or hippocampal bioamine levels, suggesting an important role of these regions in the responsiveness of the pig to acute stress conditions [3,20]. Furthermore, the involvement of central nervous system NT in aggressiveness and dominance has also been studied [21][22][23][24].…”

Section: Introductionmentioning

confidence: 99%

Effect of handling on neurotransmitter profile in pig brain according to fear related behaviour

Arroyo

Carreras

Valent

et al. 2016

Physiology & Behavior

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“…The concentration of L-DOPA in striatal tissue samples was measured with a HPLC system as described earlier [ 53 ]. Samples of 100 μl were injected into the column (Kinetex XD-C18, 2.6 μm, 100 Å, 100 × 4.6 mm; Phenomenex) with an autoinjector (Prominence Auto Sampler, SIL-20 AC, Shimadzu).…”

Section: Methodsmentioning

confidence: 99%

Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) Elevates Stimulus-Evoked Release of Dopamine in Freely-Moving Rats

et al. 2018

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Neurotrophic factors (NTFs) hold potential as disease-modifying therapies for neurodegenerative disorders like Parkinson’s disease. Glial cell line-derived neurotrophic factor (GDNF), cerebral dopamine neurotrophic factor (CDNF), and mesencephalic astrocyte-derived neurotrophic factor (MANF) have shown neuroprotective and restorative effects on nigral dopaminergic neurons in various animal models of Parkinson’s disease. To date, however, their effects on brain neurochemistry have not been compared using in vivo microdialysis. We measured extracellular concentration of dopamine and activity of dopamine neurochemistry-regulating enzymes in the nigrostriatal system of rat brain. NTFs were unilaterally injected into the striatum of intact Wistar rats. Brain microdialysis experiments were performed 1 and 3 weeks later in freely-moving animals. One week after the treatment, we observed enhanced stimulus-evoked release of dopamine in the striatum of MANF-treated rats, but not in rats treated with GDNF or CDNF. MANF also increased dopamine turnover. Although GDNF did not affect the extracellular level of dopamine, we found significantly elevated tyrosine hydroxylase (TH) and catechol-O-methyltransferase (COMT) activity and decreased monoamine oxidase A (MAO-A) activity in striatal tissue samples 1 week after GDNF injection. The results show that GDNF, CDNF, and MANF have divergent effects on dopaminergic neurotransmission, as well as on dopamine synthetizing and metabolizing enzymes. Although the cellular mechanisms remain to be clarified, knowing the biological effects of exogenously administrated NTFs in intact brain is an important step towards developing novel neurotrophic treatments for degenerative brain diseases.Electronic supplementary materialThe online version of this article (10.1007/s12035-018-0872-8) contains supplementary material, which is available to authorized users.

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Evidence for a link between tail biting and central monoamine metabolism in pigs (Sus scrofa domestica)

Cited by 43 publications

References 39 publications

The effect of mixing levels on aggression at weaning in piglets

The effect of mixing levels on aggression at weaning in piglets

Effect of handling on neurotransmitter profile in pig brain according to fear related behaviour

Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) Elevates Stimulus-Evoked Release of Dopamine in Freely-Moving Rats

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