Evidence for dopamine D 1 receptor involvement in the stimulus selection task: overshadowing in the rat

O’Tuathaigh, Colm M. P.; Moran, Paula M.

doi:10.1007/s00213-002-1107-1

Cited by 22 publications

(9 citation statements)

References 31 publications

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“…Kapur, 2003, 2004). Similar to LI, overshadowing has been reported to be abolished by treatment with amphetamine (Oades et al, 1987; O’Tuathaigh and Moran, 2002, 2004; O’Tuathaigh et al, 2003) and hippocampal lesions (Schmajuk et al., 1983). Thus, the substrates responsible for this effect could well be equivalent to those mediating LI (Cassaday, 2010; Cassaday and Moran, 2010).…”

Section: Introductionmentioning

confidence: 81%

Dopamine in nucleus accumbens: salience modulation in latent inhibition and overshadowing

et al. 2011

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Latent inhibition (LI) is demonstrated when non-reinforced pre-exposure to a to-be-conditioned stimulus retards later learning. Learning is similarly retarded in overshadowing, in this case using the relative intensity of competing cues to manipulate associability. Electrolytic/excitotoxic lesions to shell accumbens (NAc) and systemic amphetamine both reliably abolish LI. Here a conditioned emotional response procedure was used to demonstrate LI and overshadowing and to examine the role of dopamine (DA) within NAc. Experiment 1 showed that LI but not overshadowing was abolished by systemic amphetamine (1.0 mg/kg i.p.). In Experiment 2, 6-hydroxydopamine (6-OHDA) was used to lesion DA terminals within NAc: both shell- and core- (plus shell-)lesioned rats showed normal LI and overshadowing. Experiment 3 compared the effects of amphetamine microinjected at shell and core coordinates prior to conditioning: LI, but not overshadowing, was abolished by 10.0 but not 5.0 µg/side amphetamine injected in core but not shell NAc. These results suggest that the abolition of LI produced by NAc shell lesions is not readily reproduced by regionally restricted DA depletion within NAc; core rather than shell NAc mediates amphetamine-induced abolition of LI; overshadowing is modulated by different neural substrates.

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Section: Introductionmentioning

confidence: 81%

Dopamine in nucleus accumbens: salience modulation in latent inhibition and overshadowing

et al. 2011

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“…These data indicate that amphetamine effects on LI and overshadowing are differentially sensitive to antagonism of D 1 and D 2 receptors. Consistent with this dissociable pharmacological profile, the partial D 1 agonist SKF 38393 is able to disrupt overshadowing but not LI (Feldon et al 1991; Loskutova et al 2010; O'Tuathaigh & Moran, 2002; Zelikowsky & Fanselow, 2010). …”

Section: Introductionmentioning

confidence: 88%

“…Nelson et al 2011 a ). SCH 23390 doses in the range of 0.01–0.05 mg/kg have previously been shown to antagonize amphetamine abolition of overshadowing as well as block the disruptive effects of nicotine on LI (O'Tuathaigh & Moran, 2002; Young et al 2005). The dose of SCH 23390 was reduced to 0.02 mg/kg in expt 3, based on the results of expt 2, and to match that demonstrated to reverse the effects of nicotine on LI measured in the same fear conditioning procedure (Young et al 2005).…”

Section: Methodsmentioning

confidence: 99%

“…Normally a more intense stimulus acquires associative strength at the expense of a relatively less intense stimulus (Pavlov, 1927). Overshadowing has similarly been shown to be disrupted by acute treatment with amphetamine (O'Tuathaigh & Moran, 2002, 2004; O'Tuathaigh et al 2003). …”

Section: Introductionmentioning

confidence: 99%

“…Weiner, 2003). On the other hand, the disruptive effects of amphetamine on overshadowing are not blocked by the D 2 antagonists haloperidol, raclopride or sulpriride but are reversed by the D 1 antagonist SCH 23390 (O'Tuathaigh & Moran, 2002, 2004). These data indicate that amphetamine effects on LI and overshadowing are differentially sensitive to antagonism of D 1 and D 2 receptors.…”

Section: Introductionmentioning

confidence: 99%

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Dopamine D1 receptor involvement in latent inhibition and overshadowing

Nelson

Thur

Cassaday

2011

Int. J. Neuropsychopharm.

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Latent inhibition (LI) manifests as poorer conditioning to a stimulus that has previously been experienced without consequence. There is good evidence of dopaminergic modulation of LI, as the effect is reliably disrupted by the indirect dopamine (DA) agonist amphetamine. The disruptive effects of amphetamine on LI are reversed by both typical and atypical antipsychotics, which on their own are able to facilitate LI. However, the contribution of different DA receptors to these effects is poorly understood. Amphetamine effects on another stimulus selection procedure, overshadowing, have been suggested to be D1-mediated. Thus, in the current experiments, we systematically investigated the role of D1 receptors in LI. First, we tested the ability of the full D1 agonist SKF 81297 to abolish LI and compared the effects of this drug on LI and overshadowing. Subsequently, we examined whether the D1 antagonist SCH 23390 can lead to the emergence of LI under conditions that do not produce the effect in normal animals (weak pre-exposure). Finally, we tested the ability of SCH 23390 to block amphetamine-induced disruption of LI. We found little evidence that direct stimulation of D1 receptors abolishes LI (although there was some attenuation of LI at 0.4 mg/kg SKF 81297). Similarly, SCH 23390 failed to enhance LI. However, SCH 23390 did block amphetamine-induced disruption of LI. These data indicate that, while LI may be unaffected by selective manipulation of activity at D1 receptors, the effects of amphetamine on LI are to some extent dependent on actions at D1 receptors.

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Overshadowing in conditioned taste aversion or in conditioned emotional response after neonatal ventral hippocampal lesions in rats

Macedo

Angst

Gounot

et al. 2008

Behavioural Brain Research

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Evidence for dopamine D 1 receptor involvement in the stimulus selection task: overshadowing in the rat

Abstract: These data indicate a modulatory role for the DA D(1) receptor in the expression of stimulus selection and suggest that the DA D(1) receptor might play a role in salience allocation aspects of learning.

Cited by 22 publications

References 31 publications

Dopamine in nucleus accumbens: salience modulation in latent inhibition and overshadowing

Dopamine in nucleus accumbens: salience modulation in latent inhibition and overshadowing

Dopamine D1 receptor involvement in latent inhibition and overshadowing

Overshadowing in conditioned taste aversion or in conditioned emotional response after neonatal ventral hippocampal lesions in rats

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