Evidence for hypomotility in non-ulcer dyspepsia: a prospective multifactorial study.

Abstract

A prospective multifactorial study of symptoms and disturbance of gastrointestinal function has been undertaken in 50 patients with non-ulcer dyspepsia. Objective tests including solid meal gastric emptying studies, gastric acid secretion, E-HIDA scintiscan for enterogastric bile reflux, and hydrogen breath studies were carried out in all patients and validated against control data. Gastroscopy and biopsy were carried out in non-ulcer dyspepsia patients only. Non-ulcer dyspepsia patients were categorised on the basis of predominant symptoms as: dysmotility-like dyspepsia (n=22); essential dyspepsia (n= 14), gastro-oesophageal reflux-like dyspepsia (n= 11); and ulcer-like dyspepsia (n=3). In the total non-ulcer dyspepsia population, solid meal gastric emptying was delayed (T50 mean (SEM)= 102 (6)

Effect of Helicobacter pylori eradication on gastric emptying and symptoms in patients with dyspepsia

“…W czasie włączania do badania oraz 2 tyg. po skutecznej eradykacji wypełniali oni kwestionariusz mający na celu określe-nie nasilenia objawów dyspeptycznych oraz zostali poddani pomiarowi GE z posiłku stałego o wartości energetycznej 378 kcal z dodatkiem 75 μl 13 C-kwasu oktanowego. Wartości normatywne kinetyki GE wyznaczono u 12 zdrowych osób.…”

“…Using algorithms of non-linear regression implemented in the Statistica 6.1 software [12], the curves of momentary 13 C recovery within the exhaled air were fitted to the function:…”

“…They are harmless, noninvasive, and easy to perform, even in elderly or disabled patients. Accordingly, repeated GE studies with breath tests involving the stable 13 C isotope are entirely acceptable even in children and pregnant women [7][8][9].…”

Detection of patients with functional dyspepsia using wavelet transform applied to their electrogastrogram

“…The role of Helicobacter pylori infection has been controversial but more recent studies have revealed small benefit from H. pylori eradication. Gastric sensorimotor abnormalities have been extensively investigated in patients with FD and delayed gastric emptying has been considered the most important mechanism since an abnormal gastric emptying was observed in 20 to 50% of patients with FD (3,4), but the relationship between abnormalities of gastric emptying and symptoms is unclear. Impaired gastric accommodation to a meal has been demonstrated in patients with FD by studies on the gastric barostat, causing an abnormal intragastric distribution of food.…”

Gastric myoelectrical activity abnormalities of electrogastrography in patients with functional dyspepsia

“…Some genetic factors such as polymorphism or psychosocial factors or some other factors regarding bacterial flora are likely responsible for pathogenesis (2,5). Most of the patients with dyspeptic complaints of unknown cause were found to have various gastric and duodenal motility abnormalities leading to antral hypomotility (6,7), gastric motor abnormalities due to abnormal gastric myoelectrical activity, and delayed gastric emptying (8).…”