Evidence for linkage equilibrium between two RFLPs associated with the human SST locus

Abstract

Haplotypes were established for the alleles at the EcoRI and BamHI polymorphic restriction sites associated with the human somatostatin (SST) gene. The two genetic markers, in spite of their proximity, are in linkage equilibrium.

Principal predictors of major adverse limb events in diabetic peripheral artery disease: A narrative review

“…In particular, endovascular revascularization guarantees lower short-term adverse events, especially in PAD patients characterized by significant frailty related to comorbidities [ [198] , [199] , [200] , [201] ]. First, surgical suitability should be always evaluated [ 202 , 203 ] and endovascular revascularization should be offered as a second valid option in patients with high surgical risks or unfavorable vascular characteristics [ 204 ], although a higher incidence of MALE was observed. The most suitable surgical strategy should be determined considering personal characteristics and the individual surgical risks [ 205 ].…”

Multiple Restriction Site Polymorphism at the Human Somatostatin Locus: A Population Study in Italy

“…Both the polymor phisms with PIC values of 0.164 and 0.122, respectively, were scarcely informa tive per se. In spite of their proximity we found a linkage equilibrium between the alleles at the two loci [7]. Therefore these sites define four haplotypic combinations that may be considered as multiple alleles, since the recombination over a distance of the order of 5.4 kb is expected to be negli gible.…”

DNA Restriction Fragment Analysis of the Somatostatin Gene in Familial Isolated Growth Hormone Deficiency Type I

“…The same table also shows the expected haplotypes for the control group, calculated as the product of the respective allele frequencies given the locus independence [4], A comparison of the two groups gave a x2 of 1.946 with 3 d.f., indicating that the observed differences in the frequen cies are again not significant.…”