2016
DOI: 10.1007/s00424-016-1835-4
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Evidence for the functional involvement of members of the TRP channel family in the uptake of Na+ and NH4 + by the ruminal epithelium

Abstract: Large quantities of protein are degraded in the fermentative parts of the gut to ammonia, which is absorbed, detoxified to urea, and excreted, leading to formation of nitrogenous compounds such as N2O that are associated with global warming. In ruminants, channel-mediated uptake of NH4 (+) from the rumen predominates. The molecular identity of these channels remains to be clarified. Ruminal cells and epithelia from cows and sheep were investigated using patch clamp, Ussing chamber, microelectrode techniques, a… Show more

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Cited by 34 publications
(110 citation statements)
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“…Modified from Wilkens et al (2016). menthol enhanced Ca net flux rates determined for ovine rumen epithelia in Ussing chambers from 8.60 ± 1.43 to 13.24 ± 0.91 nmol/cm 2 •h and Na-mediated short-circuit currents (Rosendahl et al, 2016). In dairy cows, oral administration of 1.2 g essential oils with menthol as the major compound increased plasma Ca from 2.46 to 2.53 mM and decreased plasma urea from 4.28 to 3.92 mM (Braun et al, 2019).…”
Section: Transcellular Pre-intestinal Calcium Absorptionmentioning
confidence: 99%
“…Modified from Wilkens et al (2016). menthol enhanced Ca net flux rates determined for ovine rumen epithelia in Ussing chambers from 8.60 ± 1.43 to 13.24 ± 0.91 nmol/cm 2 •h and Na-mediated short-circuit currents (Rosendahl et al, 2016). In dairy cows, oral administration of 1.2 g essential oils with menthol as the major compound increased plasma Ca from 2.46 to 2.53 mM and decreased plasma urea from 4.28 to 3.92 mM (Braun et al, 2019).…”
Section: Transcellular Pre-intestinal Calcium Absorptionmentioning
confidence: 99%
“…Our own interest in TRP channels was sparked when attempting to identify proteins involved in ammonia transport by gastrointestinal epithelia [ 11 13 ]. Large quantities of ammonia are produced in the fermentative parts of the gut from microbial degradation of nitrogenous compounds and subsequently absorbed.…”
Section: Introductionmentioning
confidence: 99%
“…Importantly, Mg is involved in the gating of numerous ion channels (Vemana, Pandey, & Larsson, ). In the rumen, non‐selective cation channels such as TRPV3 (transient receptor potential vanilloid type 3 channel) are regulated by Mg in a voltage‐dependent manner, with possible implications for ruminal ion transport (Leonhard‐Marek, Stumpff, Brinkmann, Breves, & Martens, ; Rosendahl, Braun, Schrapers, Martens, & Stumpff, ; Schrapers, Sponder, Liebe, Liebe, & Stumpff, ; Stumpff & Martens, ).…”
Section: Introductionmentioning
confidence: 99%