Evidence in Guidelines for Treatment of Coronary Artery Disease

Jia, Sida; Liu, Yue; Yuan, Jinqing

doi:10.1007/978-981-15-2517-9_2

Cited by 79 publications

(59 citation statements)

References 85 publications

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Section: Introductionmentioning

confidence: 99%

“…Acute coronary syndrome (ACS) is a category of clinically severe coronary artery disease (CAD) characterized by the acute rupture of vulnerable atherosclerotic plaques and subsequent total occlusion of the coronary arteries [1,2]. Clinically, ACS could be further classified as ST segment elevated myocardial infarction (STEMI) and non-ST segment elevated ACS (NSTE-ACS) [1]. Despite of continuing advances in the treatment of ACS, particularly of the revascularization therapy such as percutaneous coronary intervention (PCI), patients with ACS remain of poor prognosis [3,4].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Triglyceride-Glucose Index Predicts Adverse Events in Patients with Acute Coronary Syndrome: A Meta-Analysis of Cohort Studies

Ren

Chang

et al. 2021

Horm Metab Res

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The triglyceride-glucose (TyG) index, a recently proposed indicator for insulin resistance, has been related with cardiovascular risks. We aimed to summarize the association between TyG index and incidence of major adverse cardiovascular events (MACEs) in patients with acute coronary syndrome (ACS). Cohort studies demonstrating the association between TyG index and incidence of MACEs in ACS patients with multivariate adjusted analyses were identified by search of PubMed, Embase, and Web of Science databases. A random-effekt model incorporating the heterogeneity was applied to pool the results. Eight cohort studies with 19 611 participants were included. Results showed that compared to those with the lowest category of TyG index, ACS patients with the highest category of TyG index were independently associated with higher risk of MACEs [risk ratio (RR): 1.94, 95% confidence interval (CI): 1.47–2.56, I2=85%, p <0.001). Subgroup analyses showed consistent results in patients with ST-segment elevated myocardial infarction or non-ST segment elevated ACS, in patients with or without diabetes, and in patients after percutaneous coronary intervention. Results were consistent in studies with TyG index analyzed as continuous variable (RR for per standard deviation increment of TyG index: 1.59, 95% CI: 1.38–1.83, I2=24%, p <0.001). In conclusion, higher TyG index may be independently associated with higher incidence of MACEs in patients with ACS.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Triglyceride-Glucose Index Predicts Adverse Events in Patients with Acute Coronary Syndrome: A Meta-Analysis of Cohort Studies

Ren

Chang

et al. 2021

Horm Metab Res

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“…For this part of patients, long-term use of Angiotensin Converting Enzyme Inhibitor (ACEI), β-Blocker and other drugs could delay the process of ventricular remodeling and improve the prognosis to some extent. However, it is di culty for the existing therapies to bring further bene ts for patients [23]. Therefore, it is urgent to take further combination therapies, even new therapeutic agents, to achieve effective management of patients with CMI.…”

Section: Discussionmentioning

confidence: 99%

HGF Treatment Promotes Cardiac Function and Cardiac Repair: Meta-analysis of Pig Models With Myocardial Infarction

Chen

Wang

et al. 2020

Preprint

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Background: Previous studies reported that hepatocyte growth factor (HGF) could promote angiogenesis and cardiac function after myocardial infarction (MI) in pigs. However, the results of these studies were controversial. To clarify the therapeutic efficacy of local HGF administration after MI, we performed a systematic review and meta-analysis of data from the pig models, which could provide evidence for the feasibility of clinical HGF application.Methods: PubMed, EMBASE, and China National Knowledge Infrastructure were searched for randomized studies that correspond to our subject. The search terms included (hepatocyte growth factor OR HGF) AND (heart failure OR HF OR myocardial infarction OR MI OR AMI OR coronary heart disease OR CHD). The primary endpoint indicators were identified as the left ventricular ejection fraction (LVEF) and capillaries density. Other parameters reflecting cardiac function and ventricular remodeling were analyzed as secondary indicators, including ventricular volume, infarct size, apoptotic index and others.Results: In total, 9 studies were finally included in the meta-analysis. On comparing the cardiac function indexes, the HGF group was found to be better than the control group in regard to LVEF, stroke volume, left ventricular end-systolic volume (LVESV) and left ventricular end-diastolic volume (LVEDV). However, no statistically significant differences were found in heart rate. Furthermore, HGF treatment promotes angiogenesis in ischemic areas, which is manifested by increased capillary density. In addition, the HGF group was found to be better than the control group when it comes to infarct size, arteriole densities, and other indicators of cardiac remodeling.Conclusions: HGF treatment can effectively promote cardiac function and cardiac repair including angiogenesis, and this strategy is a promising cardio-protective approach that merits further clinical studies.

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“…Cardiac conditions are a major burden for health systems, worldwide [1][2] . And, low and middle-income settings (LMISs), especially in Latin America, are not strange to this reality 3 .…”

Section: Introductionmentioning

confidence: 99%

Quality evaluation in delivering care of Acute Myocardial Infarction in Sancti-Spirítus, Cuba.

Rodríguez-Ramos¹,

Cairo-Saez²,

Prohias-Martinez

2020

Preprint

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Aim: This study assesses the quality of care for patients admitted with diagnosis of acute myocardial infarction (AMI) in a secondary general hospital located in Sancti-Spiritus, Cuba, in a low/middle income scenario (LMIS), using the 2017 European Society of Cardiology (ESC) Quality of Care Working Group’s guideline.Methods: Observational retrospective of admitted AMI in Sancti-Spiritus Camilo Cienfuegos General Hospital. An implemented electronic registry was used for data collection. Each patient was considered for eligibility for each of the eight domains of quality. A set of quality measures was derived from ESC guidelines. Organizational information was assessed by administrative review and interview.Results: Between 2017 and 2019, 660 patients with AMI were admitted to Camilo Cienfuegos General Hospital, most of them (72%), presented with features of ST-elevation myocardial infarction (STEMI). Thrombolytic were administered to 268 (72.4%) patients, 43 (16%) of them in less than 30 minutes of diagnosis. Dual Antiplatelet Therapy was administered to 98.1% of patients on admission. However, only 163 (34.8%) were enrolled in secondary prevention programs. No information regarding Patient Experience, nor 30-day adjusted mortality, was collected. Secondary prevention was accomplished, around 90%.Conclusion: Determination of quality metrics brought certain improvement on perception of the quality of care in this setting. Despite absence of coronary intervention, there is a chance to modify some performance measures, which are not directly related with this doubtful situation.

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Evidence in Guidelines for Treatment of Coronary Artery Disease

Cited by 79 publications

References 85 publications

Triglyceride-Glucose Index Predicts Adverse Events in Patients with Acute Coronary Syndrome: A Meta-Analysis of Cohort Studies

Triglyceride-Glucose Index Predicts Adverse Events in Patients with Acute Coronary Syndrome: A Meta-Analysis of Cohort Studies

HGF Treatment Promotes Cardiac Function and Cardiac Repair: Meta-analysis of Pig Models With Myocardial Infarction

Quality evaluation in delivering care of Acute Myocardial Infarction in Sancti-Spirítus, Cuba.

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