Evidence of Infant Blood Pressure Programming by Maternal Nutrition during Pregnancy: A Prospective Randomized Controlled Intervention Study

Aaltonen, Jonna; Ojala, Tiina; Laitinen, Kirsi; Piirainen, Tarja Johanna; Poussa, Tuija; Isolauri, Erika

doi:10.1016/j.jpeds.2007.05.048

Cited by 44 publications

(21 citation statements)

References 39 publications

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“…Two publications from the Finnish Mother–Infant Nutrition and Probiotic Intervention assessed the effect of combined dietary counselling, and food and fortified food products (Aaltonen et al . ; Luoto et al . ).…”

Section: Resultsmentioning

confidence: 99%

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Effects of dietary interventions on pregnancy outcomes: a systematic review and meta‐analysis

Gresham

Bisquera

Byles

et al. 2014

Maternal & Child Nutrition

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Dietary intake during pregnancy influences maternal health. Poor dietary practices during pregnancy have been linked to maternal complications. The objective was to determine the effect of dietary intervention before or during pregnancy on pregnancy outcomes. A systematic review was conducted without date restrictions. Randomised controlled trials (RCTs) evaluating whole diet or dietary components and pregnancy outcomes were included. Two authors independently identified papers for inclusion and assessed methodological quality. Meta-analysis was conducted separately for each outcome using random effects models. Results were reported by type of dietary intervention: (1) counselling; (2) food and fortified food products; or (3) combination (counseling + food); and collectively for all dietary interventions. Results were further grouped by trimester when the intervention commenced, nutrient of interest, country income and body mass index. Of 2326 screened abstracts, a total of 28 RCTs were included in this review. Dietary counselling during pregnancy was effective in reducing systolic [standardised mean difference (SMD) -0.26, 95% confidence interval (CI) -0.45 to -0.07; P < 0.001] and diastolic blood pressure (SMD -0.57, 95% CI -0.75 to -0.38; P < 0.001). Macronutrient dietary interventions were effective in reducing the incidence of preterm delivery (SMD -0.19, 95% CI -0.34 to -0.04; P = 0.01). No effects were seen for other outcomes. Dietary interventions showed some small, but significant differences in pregnancy outcomes including a reduction in the incidence of preterm birth. Further high-quality RCTs, investigating micronutrient provision from food, and combination dietary intervention, are required to identify maternal diet intakes that optimise pregnancy outcomes.

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Section: Resultsmentioning

confidence: 99%

“…There was one trial (2 publications) in our review on the combination (counselling + food) dietary intervention (Aaltonen et al . ; Luoto et al . ).…”

Section: Resultsmentioning

confidence: 99%

Effects of dietary interventions on pregnancy outcomes: a systematic review and meta‐analysis

Gresham

Bisquera

Byles

et al. 2014

Maternal & Child Nutrition

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“…With all these limitations, it is unlikely that this dietary intervention impacts on childhood blood pressure because the levels were comparable both at the age of 6 months (Aaltonen et al, 2008) and 4 years. The sparse followup after the 1-year visit may be one reason for this.…”

Section: Discussionmentioning

confidence: 99%

“…We have previously shown that the maternal gestational intake of carbohydrates and monounsaturated fatty acids contributes to infant blood pressure at 6 months in a dietary intervention study cohort of healthy mother-child pairs (Aaltonen et al, 2008). In our present exploratory study, we aimed to evaluate whether the impact of intrauterine dietary related factors extend to childhood.…”

Section: Introductionmentioning

confidence: 93%

Impact of intrauterine and post‐natal nutritional determinants on blood pressure at 4 years of age

Normia

Laitinen

Isolauri

et al. 2013

J Human Nutrition Diet

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“…Blood glucose concentrations were the lowest in the diet/probiotics group during pregnancy and over the 12-mo postpartum period. Glucose tolerance was also better in the diet/probiotics group than in the control/placebo group during the last trimester of pregnancy and over the 12-mo postpartum period (16); however, the effects on blood pressure in children at 6 mo were unrelated to probiotic intake in another study (42). Finally, the effect of perinatal probiotic intervention on childhood growth patterns and the development of overweight during a 10-y follow-up was also evaluated in 159 women who were randomly assigned and double-blinded to receive L. rhamnosus GG (1 · 10 10 CFU) or placebo 4 wk before their expected delivery and for 6 mo postnatally (43).…”

Section: Effects Of Probiotic Intake During the Perinatal Period In Hmentioning

confidence: 91%

Gut microbiota and probiotics in maternal and infant health

Sanz

2011

The American Journal of Clinical Nutrition

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The interplay between both heredity and environmental factors seems to affect every stage of development from conception to the early postnatal period with potential long-term effects on child and adult health. During pregnancy, immune and metabolic functions of the fetus are dependent on the mother; moreover, the refinement of these functions seems to commence inside the uterus and to be diet sensitive. The microbiota inhabiting the intestinal tract develop an array of physiologic roles within the human body, which influences both metabolic and immune functions, particularly during early neonatal life and possibly even in utero. Transmission of bacteria from the mother to the neonate through direct contact with maternal microbiota during birth and through breast milk during lactation also seems to influence the infant's gut colonization, with potential health consequences. In this context, intentional modulation of microbiota composition through the use of probiotics during the perinatal and early postnatal period has been proposed as a possible dietary strategy to reduce risk of disease. Herein, studies are reviewed on the composition of the intestinal microbiota during pregnancy and clinical trials evaluating the effects of perinatal administration of probiotics on different clinical outcomes.

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Evidence of Infant Blood Pressure Programming by Maternal Nutrition during Pregnancy: A Prospective Randomized Controlled Intervention Study

Cited by 44 publications

References 39 publications

Effects of dietary interventions on pregnancy outcomes: a systematic review and meta‐analysis

Effects of dietary interventions on pregnancy outcomes: a systematic review and meta‐analysis

Impact of intrauterine and post‐natal nutritional determinants on blood pressure at 4 years of age

Gut microbiota and probiotics in maternal and infant health

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