Evidence supports blind screening for internal malignancy in dermatomyositis

Leatham, Hayley W.; Schadt, Courtney R.; Chisolm, Sarah; Fretwell, Deborah; Chung, Lorinda; Callen, Jeffrey P.; Fiorentino, David

doi:10.1097/md.0000000000009639

Cited by 88 publications

(65 citation statements)

References 17 publications

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“…The association between DM and malignancy is well documented; DM can occur at the same time as, before, or after cancer diagnosis ( 3 , 4 , 16 , 17 ). The precise association between DM and malignancy is unclear, but may include the following: i) DM may occur in the setting of an immunological response to an internal malignancy; ii) there may be an increased risk of cancer in the setting of immunosuppressive therapy for DM, and iii) detection rates may be increased in the setting of heightened surveillance after either diagnosis ( 18 ). It is difficult, in most cases, to determine whether a malignancy has contributed to the development of DM or whether DM has contributed to the development of a malignant tumor.…”

Section: Discussionmentioning

confidence: 99%

Characteristics and predictors of malignancy in dermatomyositis: Analysis of 239 patients from northern China

Liu

et al. 2018

Oncol Lett

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The present study aimed to determine the characteristics of patients with dermatomyositis (DM) in order to identify predictors of cancer in these patients. Data of 239 patients with DM, treated at Yuhuangding Hospital between 1997 and 2016, was retrospectively assessed. The patients' demographic, clinical, survival and laboratory data were analyzed. Of the 239 patients, 43 developed malignancies. In 30 (69.77%) patients, the malignancy was detected within 1 year before or after DM diagnosis. There were 15 (34.88%) fatalities. Lung cancer was the most common type of malignancy identified (n=6, 13.95%), and adenocarcinoma was the most common pathological type (n=6, 13.95%). Older age, absence of interstitial lung disease, and absence of arthralgia were demonstrated to be independent risk factors for malignancy. Myositis-specific autoantibody expression, specifically anti-TIF1γ positivity and/or anti-MDA5 negativity, was associated with cancer in patients with DM. The survival rate was significantly lower in patients with malignancy than in patients without malignancy. Patients with DM had a high incidence of malignancy and a poor prognosis. Lung cancer and adenocarcinoma are common among patients with DM in northern China. Cancer screening should be conducted in all DM patients, particularly within 1 year of DM diagnosis. Older age is a risk factor for malignancy in DM patients, while interstitial lung disease and arthralgia are protective factors. Myositis-specific autoantibody detection may be useful for cancer screening in patients with DM.

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Section: Discussionmentioning

confidence: 99%

Characteristics and predictors of malignancy in dermatomyositis: Analysis of 239 patients from northern China

Liu

et al. 2018

Oncol Lett

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“…Various studies have estimated the risk of cancer in DM through various methods. A retrospective study comprising a cohort of 400 DM patients reported the development of malignancy in 15.8% of patients [ 6 ]. Other reports have placed the incidence of DM as a paraneoplastic syndrome in patients with malignancy to be between 6% and 60% [ 7 , 8 ].…”

Section: Discussionmentioning

confidence: 99%

Paraneoplastic Dermatomyositis in a Case of Gallbladder Signet Ring Cell Carcinoma

Paul

Mukhopadhyay

Ghosh

et al. 2020

Cureus

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Dermatomyositis (DM), as a paraneoplastic presentation, is rare, though the incidence of malignancies in patients with DM is very high. While it has been reported with a wide range of cancers, association with gallbladder carcinoma is uncommon. Furthermore, signet ring cell carcinoma detected in the metastasis presumably from our patient's gallbladder mass is itself a rare and highly malignant variant of gallbladder adenocarcinoma. Thus, this association can be considered to be a very novel finding. We describe the case of a 64-year-old Indian man who presented with cervical lymph node swelling concurrent with facial rashes, periorbital oedema, nasal regurgitation, dysphagia and weakness in his limbs. The presence of characteristic Gottron’s papules and shawl-like truncal rash on examination led to the diagnosis of DM. Fine needle aspiration cytology (FNAC) of the cervical lymph nodes revealed metastatic signet ring cells, and contrast-enhanced CT (CECT) scan of the abdomen showed a significant gallbladder mass with liver infiltration, thus confirming the underlying association.

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“…Hastaların %40'ı DM semptom başlangıcından 1 yıl içinde tanı almış, ileri yaş tek risk faktörü olarak saptanmıştır. Predominans bir malignite net olarak belirlenememiş olup; meme, akciğer, kolorektal, safra kesesi ve nadir görülen gastrik ve timüs maligniteleri genel popülasyonla karşılaştırılabilir dağılımda bulunmuştur (52). Bir çalışmada Non-Hodgkin lenfoma, akciğer, mesane kanser riskinde daha yüksek artış bildirilmiştir (53).…”

Section: Kanser İlişkili Miyozitunclassified

Inflammatory myositis: Idiopathic? Overlap? Paraneoplastic?

Can

2019

Ege Tıp Dergisi

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İnflamatuar miyozitler temel olarak kas inflamasyonu ile karakterize, bunun yanında cilt, akciğer, kalp, gastrointestinal sistem gibi ekstramusküler tutulum yapabilen heterojen bir grup hastalıktır. Proksimal kas güçsüzlüğü, kas enzim yüksekliği, elektromiyografide miyopatik patern, kas biyopsisinde tipik histolojik bulgular, dermatomiyozitte tipik deri lezyonları ile karakterizedir. İnflamatuar miyozitler, yeni miyozit spesifik otoantikorlar, histopatolojik gelişmeler, sınıflandırma kriterlerinin ışığında; dermatomiyozit, immün aracılı nekrotizan miyopati, overlap miyozit (antisentetaz sendromunu içeren), sporodik inklüzyon cisimcikli miyozit, amiyopatik dermatomiyozit, polimiyozit, kanser ilişkili miyozit olmak üzere alt gruplara ayrılabilir.

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Evidence supports blind screening for internal malignancy in dermatomyositis

Abstract: Supplemental Digital Content is available in the text

Cited by 88 publications

References 17 publications

Characteristics and predictors of malignancy in dermatomyositis: Analysis of 239 patients from northern China

Characteristics and predictors of malignancy in dermatomyositis: Analysis of 239 patients from northern China

Paraneoplastic Dermatomyositis in a Case of Gallbladder Signet Ring Cell Carcinoma

Inflammatory myositis: Idiopathic? Overlap? Paraneoplastic?

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