Evidence that estrogen may be a key factor in hyperprolactinemic anovulation: A case report

Hyperprolactinemia and Polycystic Ovarian Syndrome

“…109 Consistent with this view is the observation that the antiestrogen tamoxifen citrate can induce ovulation in hyperprolactinemic patients. 110 However, a height ened prolactin response to TRH administration in PCO patients relative to controls is not observed. 111 Although estrogen may directly stimulate the pitu itary lactotrope to enhance prolactin secretion, it may also do so by acting indirectly by sensitizing the lactotrope to GnRH.…”