2005
DOI: 10.1038/nature04371
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Evidence that stem cells reside in the adult Drosophila midgut epithelium

Abstract: Adult stem cells maintain organ systems throughout the course of life and facilitate repair after injury or disease. A fundamental property of stem and progenitor cell division is the capacity to retain a proliferative state or generate differentiated daughter cells; however, little is currently known about signals that regulate the balance between these processes. Here, we characterize a proliferating cellular compartment in the adult Drosophila midgut. Using genetic mosaic analysis we demonstrate that differ… Show more

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Cited by 1,028 publications
(1,571 citation statements)
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References 14 publications
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“…( 2017), Tropini, Earle, Huang and Sonnenburg ( 2017); excretory system: King and Goldstein (1985), Buechner (2002), Gautam, Verma and Tapadia ( 2017); sleep and circadian system: Raizen et al. ( 2008); Trojanowski and Raizen (2016); Miyazaki, Liu and Hayashi ( 2017); others: Micchelli and Perrimon (2006), Ohlstein and Spradling (2006), Chaturvedi, Reichert, Gunage and VijayRaghavan ( 2017), Gunage, Dhanyasi, Reichert and VijayRaghavan (2017)…”
Section: Research Organisms For Agingmentioning
confidence: 99%
“…( 2017), Tropini, Earle, Huang and Sonnenburg ( 2017); excretory system: King and Goldstein (1985), Buechner (2002), Gautam, Verma and Tapadia ( 2017); sleep and circadian system: Raizen et al. ( 2008); Trojanowski and Raizen (2016); Miyazaki, Liu and Hayashi ( 2017); others: Micchelli and Perrimon (2006), Ohlstein and Spradling (2006), Chaturvedi, Reichert, Gunage and VijayRaghavan ( 2017), Gunage, Dhanyasi, Reichert and VijayRaghavan (2017)…”
Section: Research Organisms For Agingmentioning
confidence: 99%
“…To further establish the role of NT on intestinal lipid absorption and AMPK regulation, human full-length NT cDNA was expressed in Drosophila midgut EE cells using the EE cell-specific driver Gr36C -Gal4 22 (see colocalization with EE-specific transcription factor Prospero 23,24 ; Extended Data Fig. 6a, b); mature NT 113 peptide was detected in larval gut (3.1fg/gut) and Drosophila S2 cells transfected with NT cDNA (Extended Data Fig.…”
mentioning
confidence: 99%
“…ISCs are randomly scattered along the basal membrane of the intestinal tube and, following division, they are proposed to give rise to EBs, which differentiate into either EEs or ECs (Ohlstein and Spradling, 2006) (Micchelli and Perrimon, 2006). ISCs can divide both symmetrically and asymmetrically.…”
Section: Structure Of the Adult Drosophila Midgutmentioning
confidence: 99%
“…Its short life cycle and amenable genetics has made it an unbeatable model system for the study of key developmental processes (Nusslein-Volhard and Wieschaus, 1980). Furthermore, since the groundbreaking discovery of the presence of stem cells in the adult Drosophila midgut (Micchelli and Perrimon, 2006) (Ohlstein and Spradling, 2006) the fly gut has represented an invaluable research system in fields such as stem cell biology, host-pathogen interactions, metabolism and ageing among others. A comprehensive overview of the multiple physiological functions of the Drosophila gut can be found in a recent review by B. Lemaitre and I. Miguel-Aliaga (Lemaitre and MiguelAliaga, 2013).…”
Section: Introductionmentioning
confidence: 99%