Evidence that temporal lobe is a default area in absence epilepsy

Temporal current-source of spikes suggests initial treatment failure in childhood absence epilepsy

“…These observations demonstrate the involvement of the hippocampus and the interplay between the hippocampal and cortico-thalamocortical circuits in typical absence seizures [34,35]. Some clinical studies have also reported temporal lobe involvement in typical absence seizures [31,32]. Focal spike slow-wave discharges observed in the temporal lobe in CAE patients [31], which suggests that the temporal area may be a part of the epileptic network in CAE.…”

“…Focal spike slow-wave discharges observed in the temporal lobe in CAE patients [31], which suggests that the temporal area may be a part of the epileptic network in CAE. Focal temporal electroclinical transformation from typical absence seizures was observed in video-EEG monitoring of two CAE patients [32]. The patients had no evidence of underlying temporal lobe dysfunction [32].…”

“…Focal temporal electroclinical transformation from typical absence seizures was observed in video-EEG monitoring of two CAE patients [32]. The patients had no evidence of underlying temporal lobe dysfunction [32]. The authors suggested that the temporal lobe may have a function in CAE as a default component of the neuronal network involved with typical absence seizures [32].…”

“…The patients had no evidence of underlying temporal lobe dysfunction [32]. The authors suggested that the temporal lobe may have a function in CAE as a default component of the neuronal network involved with typical absence seizures [32].…”

“…The cortical areas activated by absence seizures may vary according to individual susceptibility [11]. Recent evidence has demonstrated the involvement of the temporal lobe in typical absence seizures [17,[31][32][33][34]. An experimental study showed bilateral synchronization of the hippocampi during GSWDs in a pharmacologically induced animal model of typical absence seizures [34].…”