Evidences on sodium ions compartmentalization in biological systems due to pathological states. A noninvasive NMR study

Lupu, Mihaela; Ojcius, David M.; Perfettini, Jean-Luc; Patry, Jacqueline; Dimicoli, Jean‐Luc; Mispelter, Joël

doi:10.1016/s0300-9084(03)00122-6

Cited by 9 publications

(5 citation statements)

References 41 publications

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“…The observed increase in the T 2(1) relaxation time constant during curing (Figure 2A) may be ascribed to a curing-induced change in the constituents/ macromolecules binding sodium. This is in agreement with a study on liver, where an increase the relaxation time of the population (T 2(1) ) was found during ischemia, which was suggested to reflect changes in the exposure of membrane constituents during tissue deterioration (29). Accordingly, most probably the two sodium populations represent two water fractions in exchange located in the myofibrillar spaces.…”

Section: Discussionsupporting

confidence: 92%

“…We performed triple-quantum filtered imaging of the brine-saturated meat, and this demonstrated that only a small proportion of the signal intensity exhibited triplequantum coherence. This may at first indicate that the signal of the fast population does not arise from bound sodium due to quadrupolar splitting; however, under some conditions no triplequantum filtered signal may be observed, despite the presence of bound sodium ions (29). Indeed, Lupu et al ( 29) established a bound sodium population exhibiting quadrupolar coherence in liver tissue with T 2 relaxation times of ∼10-15 ms, on the same order as our fast T 2 component (T 2 (1) ).…”

Section: Discussionmentioning

confidence: 99%

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Salt Diffusion and Distribution in Meat Studied by²³Na Nuclear Magnetic Resonance Imaging and Relaxometry

Bertram

Holdsworth

Whittaker

et al. 2005

J. Agric. Food Chem.

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This study introduces the use of combined 23Na magnetic resonance imaging (MRI) and 23Na NMR relaxometry for the study of meat curing. The diffusion of sodium ions into the meat was measured using 23Na MRI on a 1 kg meat sample brined in 10% w/w NaCl for 3-100 h. Calculations revealed a diffusion coefficient of 1 x 10(-5) cm2/s after 3 h of curing and subsequently decreasing to 8 x 10(-6) cm2/s at longer curing times, suggesting that changes occur in the microscopic structure of the meat during curing. The microscopic mobility and distribution of sodium was measured using 23Na relaxometry. Two sodium populations were observed, and with increasing length of curing time the relaxation times of these changed, reflecting a salt-induced swelling and increase in myofibrillar pore sizes. Accordingly, the present study demonstrated that pore size and thereby salt-induced swelling in meat can be assessed using 23Na relaxometry.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Salt Diffusion and Distribution in Meat Studied by²³Na Nuclear Magnetic Resonance Imaging and Relaxometry

Bertram

Holdsworth

Whittaker

et al. 2005

J. Agric. Food Chem.

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“…However, like other forms of cell death, phosphatidylserine is exposed on the cell surface [119,120], and the nonapoptotic cell death is sufficient to induce uptake of the infected cell by professional phagocytes such as DC [79]. Thus, Chlamydia-induced cell death may be relevant for the immune response by transmitting Chlamydia-derived antigens to professional antigenpresenting cells.…”

Section: Induction Of Host-cell Deathmentioning

confidence: 99%

Host-Cell Survival and Death During Chlamydia Infection

Ying¹,

Pettengill²,

Ojcius³

et al. 2007

CIR

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Different Chlamydia trachomatis strains are responsible for prevalent bacterial sexually-transmitted disease and represent the leading cause of preventable blindness worldwide. Factors that predispose individuals to disease and mechanisms by which chlamydiae cause inflammation and tissue damage remain unclear. Results from recent studies indicate that prolonged survival and subsequent death of infected cells and their effect on immune effector cells during chlamydial infection may be important in determining the outcome. Survival of infected cells is favored at early times of infection through inhibition of the mitochondrial pathway of apoptosis. Death at later times displays features of both apoptosis and necrosis, but pro-apoptotic caspases are not involved. Most studies on chlamydial modulation of host-cell death until now have been performed in cell lines. The consequences for pathogenesis and the immune response will require animal models of chlamydial infection, preferably mice with targeted deletions of genes that play a role in cell survival and death.

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“…[22] et l'équipe de Ouwerkerk [23], donne des informations fonctionnelles. L'ion sodium ( 23 Na) est une sonde endogène idéale pour cartographier le compartiment extracellulaire et pour caractéri-ser la densité cellulaire due au gradient de concentration du sodium existant entre le compartiment intracellulaire (15 mM) et le compartiment extracellulaire (150 mM).…”

Section: Photosensibilisateurs Ciblés De Troisième Générationunclassified

La lumiére pourrait-elle traiter le cancer par interactions lumiére-vivant ?

et al. 2017

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Depuis plusieurs milliers d'années, la lumière qu'elle soit naturelle ou artificielle a été utilisée comme traitement de maladies de la peau, des yeux ou contre le cancer. Ce n'est qu'au début du XXe siècle que la science s'est intéressée aux interactions « lumière-vivant ». La compréhension de l'action conjuguée, dénommée « photothérapie dynamique », d'un médicament non toxique à l'obscurité, de l'oxygène et de la lumière a permis de mettre au point un protocole d'éradication de tumeurs bénignes ou malignes et d'anomalies vasculaires. Depuis environ 30 ans, on voit apparaître de nombreuses molécules photoactivables de plus en plus efficaces. Peu de molécules photosensibles ont encore atteint le stade clinique, mais les résultats publiés dans la littérature scientifique montrent que la photothérapie dynamique est en plein développement et a un avenir certain [1-3].

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Evidences on sodium ions compartmentalization in biological systems due to pathological states. A noninvasive NMR study

Cited by 9 publications

References 41 publications

Salt Diffusion and Distribution in Meat Studied by²³Na Nuclear Magnetic Resonance Imaging and Relaxometry

Salt Diffusion and Distribution in Meat Studied by²³Na Nuclear Magnetic Resonance Imaging and Relaxometry

Host-Cell Survival and Death During Chlamydia Infection

La lumiére pourrait-elle traiter le cancer par interactions lumiére-vivant ?

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Evidences on sodium ions compartmentalization in biological systems due to pathological states. A noninvasive NMR study

Cited by 9 publications

References 41 publications

Salt Diffusion and Distribution in Meat Studied by23Na Nuclear Magnetic Resonance Imaging and Relaxometry

Salt Diffusion and Distribution in Meat Studied by23Na Nuclear Magnetic Resonance Imaging and Relaxometry

Host-Cell Survival and Death During Chlamydia Infection

La lumiére pourrait-elle traiter le cancer par interactions lumiére-vivant ?

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Product

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Salt Diffusion and Distribution in Meat Studied by²³Na Nuclear Magnetic Resonance Imaging and Relaxometry

Salt Diffusion and Distribution in Meat Studied by²³Na Nuclear Magnetic Resonance Imaging and Relaxometry