Evidência de alterações de permeabilidade vascular na dengue: quando a dosagem de albumina sérica define o quadro?

Brito, Carlos; Albuquerque, Maria de Fátima Militão de; Lucena‐Silva, Norma

doi:10.1590/s0037-86822007000200015

Cited by 11 publications

(6 citation statements)

References 9 publications

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“…Other spontaneous hemorrhagic manifestations occurred with high frequency but less severity among patients with DHF and CD in our study, but severe bleeding was only observed in patients with DHF. Our findings for hemorrhage are similar to those reported previously 18,20 .…”

Section: Discussionsupporting

confidence: 93%

Predictive factors of dengue severity in hospitalized children and adolescents in Rio de Janeiro, Brazil

Ferreira

Kubelka

Velarde

et al. 2018

Rev. Soc. Bras. Med. Trop.

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Introduction: Dengue is one of the most important mosquito-borne infections. Severe cases are more frequently observed in adults. However, in 2008, the State of Rio de Janeiro, Brazil, experienced a severe dengue epidemic that primarily affected children and caused many cases of dengue hemorrhagic fever (DHF) and death. Methods: A cross-sectional analytical study was conducted to examine laboratory diagnosis and clinical epidemiologic factors for confirmed dengue cases in patients aged less than 16 years, from January to June 2008, at a municipal hospital in the City of Rio de Janeiro, Brazil. Variables associated with severe outcomes and P values less than .05 were evaluated by means of a logistic regression model. Results: Of the 419 dengue cases studied, 296 were classified as DHF and 123 as classical dengue. Six patients who had DHF died. In multivariate analysis, some laboratory and clinical variables were independently associated with DHF: age 5 years or older (odds ratio [OR], 4.94;

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Section: Discussionsupporting

confidence: 93%

Predictive factors of dengue severity in hospitalized children and adolescents in Rio de Janeiro, Brazil

Ferreira

Kubelka

Velarde

et al. 2018

Rev. Soc. Bras. Med. Trop.

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“…Similar results were obtained in a study conducted by Rajoo Singh Chhina et al among patients of dengue viral fever and found that 30% patients had serum alkaline phosphatase levels raised than normal (17). Similar results were obtained in a study conducted by Brito et al among patients of dengue viral fever and found that 70 % patients had low total patients serum proteins and 71% of patients had shown hypoalbuminemia (16).…”

Section: Discussionsupporting

confidence: 88%

Assessment of Liver Function Tests in Dengue Fever

Gupta

2019

IJMBS

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Background: The prevalence of dengue viral infection has tended to rise globally in the recent decades. In India the burden and prevalence of dengue viral infection is increasing as trends reported globally. Hence, along with global pandemic concern dengue has become major public health concern in India. Dengue is an emerging epidemic disease and several outbreaks among every state of India is being reported from time to time. Material & Methods: The present cross-sectional study includes 50 Patients who had dengue IgM antibody positive were enrolled from outdoor and from ward by simple random sampling. Clearance from Institutional Ethics Committee was taken before start of study. Written informed consent was taken from each study participant. Results: 10 (20%) patients had normal serum ALT levels, 13 (26%) patients had serum ALT levels raised less than Two-folds, 12 (24%) patients had serum ALT levels raised more than Two-folds, 11 (22%) patients had serum ALT levels raised more than four-folds and 04 (8%) patients had serum ALT levels raised more than ten folds. Among the total study participants 7 (14%) had normal serum AST levels, 14 (28%) patients had serum AST levels raised less than Two-folds, 14 (28%) patients had serum AST levels raised more than Two-folds, 12 (24%) patients had serum AST levels raised more than four-folds and 03 (6%) patients had serum AST levels raised more than ten folds. Conclusion: Liver function deterioration in dengue fever was varied from normal range of biochemical markers to raised liver function markers. AST elevation was more statistically significant than ALT. Hyperbilirubinemia and raised alkaline phosphatase levels were reported. Low serum albumin levels were associated with critical phase of the liver disease. Key words: Dengue fever, Hyperbilirubinemia, AST, ALT.

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“…Low levels of serum albumin have been associated with an increased risk of death for dengue patients and among the general population of critical care patients [ 30 , 31 ]. Hypoalbuminemia is a classical marker of plasma leakage in dengue patients and can be useful as a early sign of severity [ 30 , 32 ]. Regarding leucocyte count, a recent study showed that increased leucocyte and cell band counts were associated with bacterial infection and a higher risk of death in dengue patients [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

Clinical Profiles and Factors Associated with Death in Adults with Dengue Admitted to Intensive Care Units, Minas Gerais, Brazil

Amâncio

Heringer²,

Oliveira

et al. 2015

PLoS ONE

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The purpose of our study was to describe the clinical profile of dengue-infected patients admitted to Brazilian intensive care units (ICU) and evaluate factors associated with death. A longitudinal, multicenter case series study was conducted with laboratory-confirmed dengue patients admitted to nine Brazilian ICUs situated in Minas Gerais state, southeastern Brazil from January 1, 2008, to December 31, 2013. Demographic, clinical and laboratory data; disease severity scores; and mortality were evaluated. A total of 97 patients were studied. The in-ICU and in-hospital mortality rates were 18.6% and 19.6%, respectively. Patients classified as having severe dengue according to current World Health Organization classifications showed an increased risk of death in a univariate analysis. Nonsurvivors were older, exhibited lower serum albumin concentrations and higher total leukocyte counts and serum creatinine levels. Other risk factors (vomiting, lethargy/restlessness, dyspnea/respiratory distress) were also associated with death in a univariate analysis. Multivariate analysis indicated that in-hospital mortality was significantly associated with Acute Physiology and Chronic Health Evaluation II and the Sequential Organ Failure Assessment score. The ICU and in-hospital mortality observed in this study were higher than values reported in similar studies. An increased frequency of ICU admission due to severe organ dysfunction, higher severity indices and scarcity of ICU beds may partially explain the higher mortality.

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Evidência de alterações de permeabilidade vascular na dengue: quando a dosagem de albumina sérica define o quadro?

Cited by 11 publications

References 9 publications

Predictive factors of dengue severity in hospitalized children and adolescents in Rio de Janeiro, Brazil

Predictive factors of dengue severity in hospitalized children and adolescents in Rio de Janeiro, Brazil

Assessment of Liver Function Tests in Dengue Fever

Clinical Profiles and Factors Associated with Death in Adults with Dengue Admitted to Intensive Care Units, Minas Gerais, Brazil

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